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Modeling the non-steady state respiratory effects of remifentanil in awake and propofol-sedated healthy volunteers
Olofsen E, et al. Anesthesiology 2010 - Clinical Trial. Among authors: Aarts L. PMID 20461001
Most important model parameters were as follows: C50 for respiratory depression 1.6 +/- 0.03 ng/ml, gain of the respiratory controller (G) 0.42 - 0.1 l x min x Torr, and remifentanil blood effect site equilibration half-life (t(1/2)ke0) 0.53 +/- 0.2 min. ...
Most important model parameters were as follows: C50 for respiratory depression 1.6 +/- 0.03 ng/ml, gain of the respiratory controller (G) 0 …
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