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Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy.
Mowday AM, Ashoorzadeh A, Williams EM, Copp JN, Silva S, Bull MR, Abbattista MR, Anderson RF, Flanagan JU, Guise CP, Ackerley DF, Smaill JB, Patterson AV. Mowday AM, et al. Among authors: abbattista mr. Biochem Pharmacol. 2016 Sep 15;116:176-87. doi: 10.1016/j.bcp.2016.07.015. Epub 2016 Jul 22. Biochem Pharmacol. 2016. PMID: 27453434
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
van der Wiel AMA, Jackson-Patel V, Niemans R, Yaromina A, Liu E, Marcus D, Mowday AM, Lieuwes NG, Biemans R, Lin X, Fu Z, Kumara S, Jochems A, Ashoorzadeh A, Anderson RF, Hicks KO, Bull MR, Abbattista MR, Guise CP, Deschoemaeker S, Thiolloy S, Heyerick A, Solivio MJ, Balbo S, Smaill JB, Theys J, Dubois LJ, Patterson AV, Lambin P. van der Wiel AMA, et al. Among authors: abbattista mr. Mol Cancer Ther. 2021 Dec;20(12):2372-2383. doi: 10.1158/1535-7163.MCT-21-0406. Epub 2021 Oct 8. Mol Cancer Ther. 2021. PMID: 34625504 Free PMC article.
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
Ashoorzadeh A, Mowday AM, Guise CP, Silva S, Bull MR, Abbattista MR, Copp JN, Williams EM, Ackerley DF, Patterson AV, Smaill JB. Ashoorzadeh A, et al. Among authors: abbattista mr. Pharmaceuticals (Basel). 2022 Feb 1;15(2):185. doi: 10.3390/ph15020185. Pharmaceuticals (Basel). 2022. PMID: 35215297 Free PMC article.
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.
Abbattista MR, Ashoorzadeh A, Guise CP, Mowday AM, Mittra R, Silva S, Hicks KO, Bull MR, Jackson-Patel V, Lin X, Prosser GA, Lambie NK, Dachs GU, Ackerley DF, Smaill JB, Patterson AV. Abbattista MR, et al. Pharmaceuticals (Basel). 2021 Nov 26;14(12):1231. doi: 10.3390/ph14121231. Pharmaceuticals (Basel). 2021. PMID: 34959631 Free PMC article.
E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications.
Mowday AM, Copp JN, Syddall SP, Dubois LJ, Wang J, Lieuwes NG, Biemans R, Ashoorzadeh A, Abbattista MR, Williams EM, Guise CP, Lambin P, Ackerley DF, Smaill JB, Theys J, Patterson AV. Mowday AM, et al. Among authors: abbattista mr. Theranostics. 2020 Aug 21;10(23):10548-10562. doi: 10.7150/thno.46826. eCollection 2020. Theranostics. 2020. PMID: 32929365 Free PMC article.
40 results