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Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding.
Abbott KL, Matthews RT, Pierce M. Abbott KL, et al. J Biol Chem. 2008 Nov 28;283(48):33026-35. doi: 10.1074/jbc.M803646200. Epub 2008 Oct 6. J Biol Chem. 2008. PMID: 18838383 Free PMC article.
Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb.
Abbott KL, Troupe K, Lee I, Pierce M. Abbott KL, et al. Exp Cell Res. 2006 Sep 10;312(15):2837-50. doi: 10.1016/j.yexcr.2006.05.022. Epub 2006 Jun 21. Exp Cell Res. 2006. PMID: 16857188
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1.
Abbott KL, Archambault J, Xiao H, Nguyen BD, Roeder RG, Greenblatt J, Omichinski JG, Legault P. Abbott KL, et al. Biochemistry. 2005 Mar 1;44(8):2716-31. doi: 10.1021/bi047957p. Biochemistry. 2005. PMID: 15723517
Abbott et al. (2005) Enhanced Binding of RNAPII CTD Phosphatase FCP1 to RAP74 Following CK2 Phosphorylation, Biochemistry 44, 2732-2745, we identified a novel CK2 site adjacent to this conserved LXXLL-like motif. ...
Abbott et al. (2005) Enhanced Binding of RNAPII CTD Phosphatase FCP1 to RAP74 Following CK2 Phosphorylation, Biochemistry 44, 2732-27
Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin.
Dolezal S, Hester S, Kirby PS, Nairn A, Pierce M, Abbott KL. Dolezal S, et al. Cancer Biomark. 2014 Jan 1;14(1):55-62. doi: 10.3233/CBM-130377. Cancer Biomark. 2014. PMID: 24643042 Free PMC article.
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.
Allam H, Johnson BP, Zhang M, Lu Z, Cannon MJ, Abbott KL. Allam H, et al. J Biol Chem. 2017 Sep 29;292(39):16351-16359. doi: 10.1074/jbc.M117.783936. Epub 2017 Aug 23. J Biol Chem. 2017. PMID: 28842505 Free PMC article.
Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions.
Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL. Allam H, et al. J Proteome Res. 2015 Jan 2;14(1):434-46. doi: 10.1021/pr501174p. Epub 2014 Dec 9. J Proteome Res. 2015. PMID: 25437919 Free PMC article.
Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma.
Zhao P, Nairn AV, Hester S, Moremen KW, O'Regan RM, Oprea G, Wells L, Pierce M, Abbott KL. Zhao P, et al. J Biol Chem. 2012 Jul 20;287(30):25230-40. doi: 10.1074/jbc.M112.339465. Epub 2012 May 31. J Biol Chem. 2012. PMID: 22654114 Free PMC article.
Glycomic analysis of ovarian cancer: past, present, and future.
Abbott KL. Abbott KL. Cancer Biomark. 2010-2011;8(4-5):273-80. doi: 10.3233/CBM-2011-0218. Cancer Biomark. 2010. PMID: 22045358 Review.
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