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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2004 33
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2007 55
2008 56
2009 75
2010 69
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2013 78
2014 86
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1,353 results

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Page 1
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Maltbaek JH, Cambier S, Snyder JM, Stetson DB. Maltbaek JH, et al. Immunity. 2022 Oct 11;55(10):1799-1812.e4. doi: 10.1016/j.immuni.2022.08.006. Epub 2022 Sep 6. Immunity. 2022. PMID: 36070769 Free PMC article.
We show that ABCC1 overexpression enhanced cGAMP export and limited STING signaling and that loss of ABCC1 reduced cGAMP export and potentiated STING signaling. We demonstrate that ABCC1 deficiency exacerbated cGAS-dependent autoimmunity in the Trex1(-/-) mou …
We show that ABCC1 overexpression enhanced cGAMP export and limited STING signaling and that loss of ABCC1 reduced cGAMP expor …
ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.
Ebner J, Schmoellerl J, Piontek M, Manhart G, Troester S, Carter BZ, Neubauer H, Moriggl R, Szakács G, Zuber J, Köcher T, Andreeff M, Sperr WR, Valent P, Grebien F. Ebner J, et al. Nat Commun. 2023 Sep 19;14(1):5709. doi: 10.1038/s41467-023-41229-2. Nat Commun. 2023. PMID: 37726279 Free PMC article.
Conversely, ABCC1 overexpression induces resistance to BCL-2 inhibitors by reducing intracellular drug levels, and high ABCC1 levels predicts poor response to Venetoclax therapy in patients. Consistent with ABCC1-specific export of glutathionylated substrates …
Conversely, ABCC1 overexpression induces resistance to BCL-2 inhibitors by reducing intracellular drug levels, and high ABCC1 …
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation.
de Souza I, Monteiro LKS, Guedes CB, Silva MM, Andrade-Tomaz M, Contieri B, Latancia MT, Mendes D, Porchia BFMM, Lazarini M, Gomes LR, Rocha CRR. de Souza I, et al. Cell Death Dis. 2022 Jul 8;13(7):591. doi: 10.1038/s41419-022-05044-9. Cell Death Dis. 2022. PMID: 35803910 Free PMC article.
Altogether, our data indicate that high levels of NRF2 result in collateral sensitivity on glioblastoma via the expression of its pro-ferroptotic target ABCC1, which contributes to GSH depletion when the system xc(-) is blocked by Erastin. Thus, ferroptosis induction could …
Altogether, our data indicate that high levels of NRF2 result in collateral sensitivity on glioblastoma via the expression of its pro-ferrop …
ABCC1 is a predictive biomarker for prognosis and therapy in hepatocellular carcinoma.
Han YH, Wang YQ, Bo JQ, Guo YN, Zhang QQ, Liu LX. Han YH, et al. Eur Rev Med Pharmacol Sci. 2023 Apr;27(8):3597-3611. doi: 10.26355/eurrev_202304_32143. Eur Rev Med Pharmacol Sci. 2023. PMID: 37140311 Free article.
Immunohistochemistry staining was performed to identify ABCC1 expression in tumour samples. We further investigated the correlation between ABCC1 and clinicopathological features. ...Furthermore, we observed significant variations in immune checkpoints between the …
Immunohistochemistry staining was performed to identify ABCC1 expression in tumour samples. We further investigated the correlation b …
ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?
Bruckmueller H, Cascorbi I. Bruckmueller H, et al. Expert Opin Drug Metab Toxicol. 2021 Apr;17(4):369-396. doi: 10.1080/17425255.2021.1876661. Epub 2021 Feb 2. Expert Opin Drug Metab Toxicol. 2021. PMID: 33459081 Review.
AREAS COVERED: This review discusses the current literature on the impact of genetic variants in ABCB1, ABCG2 as well as ABCC1, ABCC2, and ABCC3 on pharmacokinetics and drug response. The aim was to evaluate if results from recent studies would increase the evidence for po …
AREAS COVERED: This review discusses the current literature on the impact of genetic variants in ABCB1, ABCG2 as well as ABCC1, ABCC2 …
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action.
Devine K, Villalobos E, Kyle CJ, Andrew R, Reynolds RM, Stimson RH, Nixon M, Walker BR. Devine K, et al. Nat Rev Endocrinol. 2023 Feb;19(2):112-124. doi: 10.1038/s41574-022-00745-9. Epub 2022 Oct 11. Nat Rev Endocrinol. 2023. PMID: 36221036 Review.
ATP-binding cassette (ABC) proteins were first shown to influence the accumulation of glucocorticoids in cells almost three decades ago, but observations over the past 10 years suggest that differential transport propensities of both exogenous and endogenous glucocorticoids by AB …
ATP-binding cassette (ABC) proteins were first shown to influence the accumulation of glucocorticoids in cells almost three decades ago, but …
ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression.
Chen L, Chen H, Xing Y, Li J. Chen L, et al. Neuroreport. 2021 Jul 7;32(10):833-839. doi: 10.1097/WNR.0000000000001657. Neuroreport. 2021. PMID: 34029289
We found that cocaine increased ABCC1 expression in the hippocampus, and ABCC1-siRNA blocked cocaine-induced place preference. ...ABCC1 is thus presented as a new signaling molecule involved in cocaine addiction, which may provide a new target for the treatme …
We found that cocaine increased ABCC1 expression in the hippocampus, and ABCC1-siRNA blocked cocaine-induced place preference. …
Overexpression of ABCC1 Confers Drug Resistance to Betulin.
Chen XY, Yang Y, Wang JQ, Wu ZX, Li J, Chen ZS. Chen XY, et al. Front Oncol. 2021 Feb 25;11:640656. doi: 10.3389/fonc.2021.640656. eCollection 2021. Front Oncol. 2021. PMID: 33718236 Free PMC article.
An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-transfected cell line to betulin and that this betulin-induced resistance can be antagonized by a known ABCC1 inhibitor MK571 at 25 muM. …
An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-tran …
ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans.
Kyle CJ, Nixon M, Homer NZM, Morgan RA, Andrew R, Stimson RH, Walker BR. Kyle CJ, et al. Metabolism. 2022 Mar;128:155118. doi: 10.1016/j.metabol.2021.155118. Epub 2022 Jan 4. Metabolism. 2022. PMID: 34990712 Free PMC article. Clinical Trial.
ABCB1 (expressed in brain) exports cortisol not corticosterone while ABCC1 (expressed in adipose and skeletal muscle) exports corticosterone not cortisol. We hypothesised that ABCC1 inhibition increases corticosteroid receptor occupancy by corticosterone but not cor …
ABCB1 (expressed in brain) exports cortisol not corticosterone while ABCC1 (expressed in adipose and skeletal muscle) exports cortico …
[New deafness gene: Progress of research on ABCC1 in biological barriers].
Zhang S, Ling J, Li M, Mei L. Zhang S, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2021 Sep 10;38(9):907-911. doi: 10.3760/cma.j.cn511374-20200519-00356. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2021. PMID: 34487542 Review. Chinese.
Previous research on ABCC1 gene has mostly focused on tumor multidrug resistance. Recently, ABCC1 has been proposed as a candidate gene for hereditary hearing impairment, which has attracted much attention. ABCC1-associated deafness may be related to its role …
Previous research on ABCC1 gene has mostly focused on tumor multidrug resistance. Recently, ABCC1 has been proposed as a candi …
1,353 results