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Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions.
Abderrahmani A, Plaisance V, Lovis P, Regazzi R. Abderrahmani A, et al. Biochem Soc Trans. 2006 Nov;34(Pt 5):696-700. doi: 10.1042/BST0340696. Biochem Soc Trans. 2006. PMID: 17052177
Since modifications in secretory functions are associated with several physiological processes and contribute to the development of human pathologies, a better knowledge of the control of the expression of the genes involved in exocytosis is urgently needed. ...These findi …
Since modifications in secretory functions are associated with several physiological processes and contribute to the development of human pa …
The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).
Abderrahmani A, Steinmann M, Plaisance V, Niederhauser G, Haefliger JA, Mooser V, Bonny C, Nicod P, Waeber G. Abderrahmani A, et al. Mol Cell Biol. 2001 Nov;21(21):7256-67. doi: 10.1128/MCB.21.21.7256-7267.2001. Mol Cell Biol. 2001. PMID: 11585908 Free PMC article.
Islet-brain 1 (IB1) is the human and rat homologue of JIP-1, a scaffold protein interacting with the c-Jun amino-terminal kinase (JNK). ...A 731-bp fragment of the 5' regulatory region of the human MAPK8IP1 gene was isolated from a human BAC library and clone …
Islet-brain 1 (IB1) is the human and rat homologue of JIP-1, a scaffold protein interacting with the c-Jun amino-terminal kinase (JNK …
The mif gene is transcriptionally regulated by glucose in insulin-secreting cells.
Plaisance V, Thompson N, Niederhauser G, Haefliger JA, Nicod P, Waeber G, Abderrahmani A. Plaisance V, et al. Biochem Biophys Res Commun. 2002 Jul 5;295(1):174-81. doi: 10.1016/s0006-291x(02)00648-4. Biochem Biophys Res Commun. 2002. PMID: 12083786
A minimal region located between -187 and -98 bp of this promoter sequence contributes both to basal activity and glucose-responsiveness of the gene. ...In conclusion, we identified a minimal region of the MIF promoter which contributes to the glucose stimulation of
A minimal region located between -187 and -98 bp of this promoter sequence contributes both to basal activity and glucose-responsiven
Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines.
Martin D, Tawadros T, Meylan L, Abderrahmani A, Condorelli DF, Waeber G, Haefliger JA. Martin D, et al. J Biol Chem. 2003 Dec 26;278(52):53082-9. doi: 10.1074/jbc.M306861200. Epub 2003 Oct 16. J Biol Chem. 2003. PMID: 14565956
A 2043-bp fragment of the human CX36 promoter was identified from a human BAC library and fused to a luciferase reporter gene. ...The NRSF-mediated repression of Cx36 in HeLa cells was abolished by trichostatin A, confirming the functional importance o
A 2043-bp fragment of the human CX36 promoter was identified from a human BAC library and fused to a luciferase reporte
Complexin I regulates glucose-induced secretion in pancreatic beta-cells.
Abderrahmani A, Niederhauser G, Plaisance V, Roehrich ME, Lenain V, Coppola T, Regazzi R, Waeber G. Abderrahmani A, et al. J Cell Sci. 2004 May 1;117(Pt 11):2239-47. doi: 10.1242/jcs.01041. J Cell Sci. 2004. PMID: 15126625
The beta-cell expression of CPX I is mediated by the presence of a neuron restrictive silencer element located within the regulatory region of the gene. ...We conclude that CPX I plays a critical role in beta-cells in the control of the stimulated-exocytosis of insu …
The beta-cell expression of CPX I is mediated by the presence of a neuron restrictive silencer element located within the regulatory …
Neuronal traits are required for glucose-induced insulin secretion.
Abderrahmani A, Niederhauser G, Plaisance V, Haefliger JA, Regazzi R, Waeber G. Abderrahmani A, et al. FEBS Lett. 2004 May 7;565(1-3):133-8. doi: 10.1016/j.febslet.2004.04.002. FEBS Lett. 2004. PMID: 15135066
The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to secrete insulin in response to mitochondrial fuels, a part …
The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content w …
The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1.
Plaisance V, Niederhauser G, Azzouz F, Lenain V, Haefliger JA, Waeber G, Abderrahmani A. Plaisance V, et al. J Biol Chem. 2005 Jan 7;280(1):401-7. doi: 10.1074/jbc.M411825200. Epub 2004 Nov 4. J Biol Chem. 2005. PMID: 15528196
The molecular mechanism by which these REST target genes are expressed only in neuronal and beta-cells and are repressed by REST in other tissues is a central issue in differentiation program of neuronal and beta-cells. ...Inhibition of REST in a non-beta and a
The molecular mechanism by which these REST target genes are expressed only in neuronal and beta-cells and are repressed by REST in other ti …
IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.
Tawadros T, Martin D, Abderrahmani A, Leisinger HJ, Waeber G, Haefliger JA. Tawadros T, et al. Cell Signal. 2005 Aug;17(8):929-39. doi: 10.1016/j.cellsig.2004.11.013. Epub 2005 Mar 3. Cell Signal. 2005. PMID: 15894166
We investigated the functional role of IB1/JIP-1 in LNCaP cells exposed to the proapoptotic agent N-(4-hydroxyphenyl)retinamide (4-HPR) which induced a reduction of IB1/JIP-1 content and a concomittant increase in JNK activity. Conversely, IB1/JIP-1 overexpression u …
We investigated the functional role of IB1/JIP-1 in LNCaP cells exposed to the proapoptotic agent N-(4-hydroxyphenyl)retinamide (4-HPR) whic …
The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor.
Abderrahmani A, Niederhauser G, Lenain V, Regazzi R, Waeber G. Abderrahmani A, et al. FEBS Lett. 2005 Nov 7;579(27):6199-204. doi: 10.1016/j.febslet.2005.09.093. Epub 2005 Oct 13. FEBS Lett. 2005. PMID: 16253247
In this study, we hypothesized that REST expression is controlled by hairy and enhancer of split 1 (HES-1), a transcriptional repressor that plays an important role in brain and pancreas development. ...Moreover, using a cells model that overexpress HES-1 and a
In this study, we hypothesized that REST expression is controlled by hairy and enhancer of split 1 (HES-1), a transcriptional repress …
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis.
Abderrahmani A, Cheviet S, Ferdaoussi M, Coppola T, Waeber G, Regazzi R. Abderrahmani A, et al. EMBO J. 2006 Mar 8;25(5):977-86. doi: 10.1038/sj.emboj.7601008. Epub 2006 Feb 23. EMBO J. 2006. PMID: 16498408 Free PMC article.
We demonstrate that the transcriptional repressor ICER, which is induced in a PKA-dependent manner by chronic hyperglycemia and cAMP-raising agents, is responsible for the decline of the four genes. ...
We demonstrate that the transcriptional repressor ICER, which is induced in a PKA-dependent manner by chronic hyperglycemia and cAMP- …
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