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Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy.
Abdollahi A, Folkman J. Abdollahi A, et al. Drug Resist Updat. 2010 Feb-Apr;13(1-2):16-28. doi: 10.1016/j.drup.2009.12.001. Epub 2010 Jan 12. Drug Resist Updat. 2010. PMID: 20061178 Review.
Moreover, the tumor endothelium has emerged as a critical target of conventional cancer therapies, such as chemotherapy and radiotherapy. ...Indeed, the majority of current anti-angiogenic approaches block the activity of a single or at most a few pro-angioge …
Moreover, the tumor endothelium has emerged as a critical target of conventional cancer therapies, such as chemotherapy and radiother …
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
Timke C, Zieher H, Roth A, Hauser K, Lipson KE, Weber KJ, Debus J, Abdollahi A, Huber PE. Timke C, et al. Among authors: abdollahi a. Clin Cancer Res. 2008 Apr 1;14(7):2210-9. doi: 10.1158/1078-0432.CCR-07-1893. Clin Cancer Res. 2008. PMID: 18381963
We found that radiation induced up-regulation of all four isoforms of PDGF (A-D) in endothelial cells supporting adjacent smooth muscle cells resulting in a prosurvival effect of radiation. ...CONCLUSION: A relative low radiation dose markedly enhances local …
We found that radiation induced up-regulation of all four isoforms of PDGF (A-D) in endothelial cells supporting adjacent smooth musc …
Transcriptional network governing the angiogenic switch in human pancreatic cancer.
Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE. Abdollahi A, et al. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. doi: 10.1073/pnas.0705505104. Epub 2007 Jul 24. Proc Natl Acad Sci U S A. 2007. PMID: 17652168 Free PMC article.
A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. ...This approach reveals a global network pattern for vascular homeostasis connecting known angiogenesis-related genes with prev
A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progress
Endostatin: the logic of antiangiogenic therapy.
Abdollahi A, Hlatky L, Huber PE. Abdollahi A, et al. Drug Resist Updat. 2005 Feb-Apr;8(1-2):59-74. doi: 10.1016/j.drup.2005.03.001. Epub 2005 Apr 7. Drug Resist Updat. 2005. PMID: 15939343 Review.
A large number of proangiogenic and antiangiogenic factors have been discovered. At least three angiogenesis inhibitors have received FDA approval in the US, with Avastin (anti-VEGF-antibody) also approved in 26 other countries. ...A particularly important question
A large number of proangiogenic and antiangiogenic factors have been discovered. At least three angiogenesis inhibitors have received
Genome wide expression profiling of angiogenic signaling and the Heisenberg uncertainty principle.
Huber PE, Hauser K, Abdollahi A. Huber PE, et al. Among authors: abdollahi a. Cell Cycle. 2004 Nov;3(11):1348-51. doi: 10.4161/cc.3.11.1209. Epub 2004 Nov 10. Cell Cycle. 2004. PMID: 15483400
The results reveal constraints on the measuring process that are of a similar kind as those implied by the uncertainty principle of quantum mechanics as described by Werner Heisenberg. ...
The results reveal constraints on the measuring process that are of a similar kind as those implied by the uncertainty principle of q …
SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.
Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE. Abdollahi A, et al. Cancer Res. 2003 Jul 1;63(13):3755-63. Cancer Res. 2003. PMID: 12839971
Here we report that ionizing radiation is a potent antiangiogenic agent that inhibits endothelial cell survival, proliferation, tube formation and invasion. ...In a coculture system of PC3 prostate cancer cells and endothelial cells, isolated irradiation of the PC3 …
Here we report that ionizing radiation is a potent antiangiogenic agent that inhibits endothelial cell survival, proliferation, tube …
Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype.
Almog N, Ma L, Schwager C, Brinkmann BG, Beheshti A, Vajkoczy P, Folkman J, Hlatky L, Abdollahi A. Almog N, et al. Among authors: abdollahi a. PLoS One. 2012;7(8):e44001. doi: 10.1371/journal.pone.0044001. Epub 2012 Aug 31. PLoS One. 2012. PMID: 22952847 Free PMC article.
Tumor dormancy refers to a critical stage in cancer development in which tumor cells remain occult for a prolonged period of time until they eventually progress and become clinically apparent. ...In addition, a G-CSF independent downregulation of Bv8 was foun …
Tumor dormancy refers to a critical stage in cancer development in which tumor cells remain occult for a prolonged period of t …
Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth.
Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L. Girdhani S, et al. Among authors: abdollahi a. Radiat Res. 2012 Jul;178(1):33-45. doi: 10.1667/rr2724.1. Epub 2012 Jun 14. Radiat Res. 2012. PMID: 22702646
Taken together, these findings provide novel pre-clinical evidence that proton irradiation may, in addition to its physical targeting advantages, have important biological ramifications that should be a consideration in the optimization of proton therapy....
Taken together, these findings provide novel pre-clinical evidence that proton irradiation may, in addition to its physical targeting advant …
Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells.
Fainaru O, Almog N, Yung CW, Nakai K, Montoya-Zavala M, Abdollahi A, D'Amato R, Ingber DE. Fainaru O, et al. Among authors: abdollahi a. FASEB J. 2010 May;24(5):1411-8. doi: 10.1096/fj.09-147025. Epub 2009 Dec 14. FASEB J. 2010. PMID: 20008545 Free PMC article.
Using mouse xenograft models of human tumors, we show that fast-growing "angiogenic" tumors are infiltrated by a more immature DC population than respective dormant avascular tumors. ...Notably, depletion of DCs in a transgenic mouse model that allows for their cond …
Using mouse xenograft models of human tumors, we show that fast-growing "angiogenic" tumors are infiltrated by a more immature DC pop …
Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype.
Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, Hlatky L, Vajkoczy P, Huber PE, Folkman J, Abdollahi A. Almog N, et al. Among authors: abdollahi a. Cancer Res. 2009 Feb 1;69(3):836-44. doi: 10.1158/0008-5472.CAN-08-2590. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176381
We have developed models in which human tumors remain dormant for a prolonged period of time (>120 days) until they switch to rapid growth and become strongly angiogenic. ...We hypothesized that dormant tumors undergo a stable genetic reprogramming during their s …
We have developed models in which human tumors remain dormant for a prolonged period of time (>120 days) until they switch to rapi …
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