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Year Number of Results
1984 1
1992 3
1994 1
1996 1
1997 1
2000 1
2001 3
2002 1
2003 1
2006 1
2007 2
2013 1
2014 1
2016 2
2017 1
2018 1
2019 1
2020 1
2022 1
2023 2

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Page 1
Enterohepatic circulation: physiological, pharmacokinetic and clinical implications.
Roberts MS, Magnusson BM, Burczynski FJ, Weiss M. Roberts MS, et al. Clin Pharmacokinet. 2002;41(10):751-90. doi: 10.2165/00003088-200241100-00005. Clin Pharmacokinet. 2002. PMID: 12162761 Review.
In general, enterohepatic recirculation may prolong the pharmacological effect of certain drugs and drug metabolites. Of particular importance is the potential amplifying effect of enterohepatic variability in defining differences in the bioavailability, apparent volume of …
In general, enterohepatic recirculation may prolong the pharmacological effect of certain drugs and drug metabolites. Of particular i …
11-Oxygenated androgens in health and disease.
Turcu AF, Rege J, Auchus RJ, Rainey WE. Turcu AF, et al. Nat Rev Endocrinol. 2020 May;16(5):284-296. doi: 10.1038/s41574-020-0336-x. Epub 2020 Mar 16. Nat Rev Endocrinol. 2020. PMID: 32203405 Free PMC article. Review.
Over the past decade, these androgens have emerged as major components of several disorders of androgen excess, such as congenital adrenal hyperplasia, premature adrenarche and polycystic ovary syndrome, as well as in androgen-dependent tumours, such as castration-resistan …
Over the past decade, these androgens have emerged as major components of several disorders of androgen excess, such as congenital ad …
Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H. Lv S, et al. Heart. 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. Heart. 2022. PMID: 34611047 Review.
Intestinal microecology comprises the gastrointestinal lumen, epithelial secretion, food entering the intestine, intestinal flora and metabolites. Choline and L-carnitine in the diet are metabolised to trimethylamine (TMA) by the intestinal micro-organisms, with TMA being …
Intestinal microecology comprises the gastrointestinal lumen, epithelial secretion, food entering the intestine, intestinal flora and met …
Genetic approaches to metabolic bone diseases.
Hannan FM, Newey PJ, Whyte MP, Thakker RV. Hannan FM, et al. Br J Clin Pharmacol. 2019 Jun;85(6):1147-1160. doi: 10.1111/bcp.13803. Epub 2018 Nov 28. Br J Clin Pharmacol. 2019. PMID: 30357886 Free PMC article. Review.
Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often associated with abnormal circulating concentrations of calcium, phosphate or vitamin D metabolites. ...
Metabolic bone diseases comprise a diverse group of disorders characterized by alterations in skeletal homeostasis, and are often associated …
Succinate metabolism and its regulation of host-microbe interactions.
Wei YH, Ma X, Zhao JC, Wang XQ, Gao CQ. Wei YH, et al. Gut Microbes. 2023 Jan-Dec;15(1):2190300. doi: 10.1080/19490976.2023.2190300. Gut Microbes. 2023. PMID: 36946592 Free PMC article. Review.
Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus. ...This revie …
Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentrat …
Imaging and epilepsy.
Duncan JS. Duncan JS. Brain. 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. Brain. 1997. PMID: 9117380 Review.
Magnetic resonance spectroscopy (MRS) provides a means of investigating cerebral metabolites and some neurotransmitters, non-invasively. The concentrations of N-acetyl-aspartate (NAA), creatine and choline-containing compounds may be estimated using proton MRS. ... …
Magnetic resonance spectroscopy (MRS) provides a means of investigating cerebral metabolites and some neurotransmitters, non-invasive …
Vitamin E inadequacy in humans: causes and consequences.
Traber MG. Traber MG. Adv Nutr. 2014 Sep;5(5):503-14. doi: 10.3945/an.114.006254. Adv Nutr. 2014. PMID: 25469382 Free PMC article. Review.
Seemingly, adequacy of human vitamin E status cannot be assessed from circulating alpha-tocopherol concentrations, but inadequacy can be determined from "low" values. Circulating alpha-tocopherol concentrations are very difficult to interpret because, …
Seemingly, adequacy of human vitamin E status cannot be assessed from circulating alpha-tocopherol concentrations, but inadequ …
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P. Olofsson P. Am J Obstet Gynecol. 2023 May;228(5S):S1222-S1240. doi: 10.1016/j.ajog.2022.07.001. Epub 2023 Mar 19. Am J Obstet Gynecol. 2023. PMID: 37164495 Free article. Review.
There is no global consensus on definitions of normal cord blood gases and lactate, and different cutoff values for abnormality are used. ...Within seconds after birth, sour metabolites accumulated in peripheral tissues and organs will flood into the central …
There is no global consensus on definitions of normal cord blood gases and lactate, and different cutoff values for abnormality …
The role of sulfated steroid hormones in reproductive processes.
Geyer J, Bakhaus K, Bernhardt R, Blaschka C, Dezhkam Y, Fietz D, Grosser G, Hartmann K, Hartmann MF, Neunzig J, Papadopoulos D, Sánchez-Guijo A, Scheiner-Bobis G, Schuler G, Shihan M, Wrenzycki C, Wudy SA, Bergmann M. Geyer J, et al. J Steroid Biochem Mol Biol. 2017 Sep;172:207-221. doi: 10.1016/j.jsbmb.2016.07.002. Epub 2016 Jul 5. J Steroid Biochem Mol Biol. 2017. PMID: 27392637 Review.
Sulfated steroid hormones, such as dehydroepiandrosterone sulfate or estrone-3-sulfate, have long been regarded as inactive metabolites as they cannot activate classical steroid receptors. Some of them are present in the blood circulation at quite high con …
Sulfated steroid hormones, such as dehydroepiandrosterone sulfate or estrone-3-sulfate, have long been regarded as inactive metabolites …
The role of protein kinase C activation and the vascular complications of diabetes.
Das Evcimen N, King GL. Das Evcimen N, et al. Pharmacol Res. 2007 Jun;55(6):498-510. doi: 10.1016/j.phrs.2007.04.016. Epub 2007 May 5. Pharmacol Res. 2007. PMID: 17574431 Review.
Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, and by resistance to insulin's effects. Such a deficiency results in increased concentrations of glucose and other metabolites in t …
Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, and by resis …
25 results