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1995 1
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Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action.
Hammond GL. Hammond GL. J Endocrinol. 2016 Jul;230(1):R13-25. doi: 10.1530/JOE-16-0070. Epub 2016 Apr 25. J Endocrinol. 2016. PMID: 27113851 Free PMC article. Review.
Albumin binds steroids with limited specificity and low affinity, but its high concentration in blood buffers major fluctuations in steroid concentrations and their free fractions. ...Understanding how the unique structures of SHBG and CBG determine their spe …
Albumin binds steroids with limited specificity and low affinity, but its high concentration in blood buffers major fluctuatio …
Revisiting antithrombin in health and disease, congenital deficiencies and genetic variants, and laboratory studies on alpha and beta forms.
Amiral J, Seghatchian J. Amiral J, et al. Transfus Apher Sci. 2018 Apr;57(2):291-297. doi: 10.1016/j.transci.2018.04.010. Epub 2018 Apr 19. Transfus Apher Sci. 2018. PMID: 29784539 Review.
Its activity is highly enhanced by heparin, through binding to the pentasaccharide sequences, for inhibition of all coagulation proteases, except thrombin, which inhibition requires its additional binding to the heparin polysaccharide chain. However, AT is the major inhibitor of …
Its activity is highly enhanced by heparin, through binding to the pentasaccharide sequences, for inhibition of all coagulation proteases, e …
Methods for measuring sulfur amino acid metabolism.
Hoffer LJ. Hoffer LJ. Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):511-7. doi: 10.1097/00075197-200209000-00009. Curr Opin Clin Nutr Metab Care. 2002. PMID: 12172474 Review.
Homocysteine is a non-protein-bound sulfur amino acid strongly implicated in the pathogenesis of several diseases. Both glutathione and homocysteine are affected by abnormalities in sulfur amino acid metabolism that occur in the clinical setting. ...There is new interest i …
Homocysteine is a non-protein-bound sulfur amino acid strongly implicated in the pathogenesis of several diseases. Both glutathione and homo …
Emerging biomarkers for the diagnosis and prognosis of prostate cancer.
Sardana G, Dowell B, Diamandis EP. Sardana G, et al. Clin Chem. 2008 Dec;54(12):1951-60. doi: 10.1373/clinchem.2008.110668. Epub 2008 Oct 16. Clin Chem. 2008. PMID: 18927246 Review.
CONTENT: PSA is produced almost exclusively in the prostate, and abnormalities of this organ are frequently associated with increased serum concentrations. ...The focus recently has been on creating cost-effective assays for circulating protein biomarkers in …
CONTENT: PSA is produced almost exclusively in the prostate, and abnormalities of this organ are frequently associated with increased …
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.
Poirier S, Mayer G. Poirier S, et al. Drug Des Devel Ther. 2013 Oct 4;7:1135-48. doi: 10.2147/DDDT.S36984. eCollection 2013. Drug Des Devel Ther. 2013. PMID: 24115837 Free PMC article. Review.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) directly binds to the epidermal growth factor-like repeat A domain of low-density lipoprotein receptor and induces its degradation, thereby controlling circulating low-density lipoprotein cholesterol (LDL-C) concentr
Proprotein convertase subtilisin/kexin type 9 (PCSK9) directly binds to the epidermal growth factor-like repeat A domain of low-density lipo …
The IGF system in metabolism regulation.
Binoux M. Binoux M. Diabete Metab. 1995 Dec;21(5):330-7. Diabete Metab. 1995. PMID: 8586149 Review.
In biological media, IGF-I and IGF-II are reversibly associated with specific high-affinity (10(9)-10(11) M-1) binding proteins (IGFBP-1 to -6) differing in expression according to tissue of origin and playing a variety of roles in IGF transport and half-lives, delivery of IGFs t …
In biological media, IGF-I and IGF-II are reversibly associated with specific high-affinity (10(9)-10(11) M-1) binding proteins (IGFBP-1 to …