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Abnormal mitochondrial function impairs calcium influx in diabetic mouse pancreatic beta cells.
Li F, Porterfield DM, Zheng XY, Wang WJ, Xu Y, Zhang ZM. Li F, et al. Chin Med J (Engl). 2012 Feb;125(3):502-10. Chin Med J (Engl). 2012. PMID: 22490411
BACKGROUND: Abnormal insulin secretion of pancreatic beta cells is now regarded as the more primary defect than the insulin function in the etiology of type 2 diabetes. ...Ca(2+) channel activity was increased and glucose induced Ca(2+) …
BACKGROUND: Abnormal insulin secretion of pancreatic beta cells is now regarded as the more primary defect than …
Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca(2+)-mediated insulin secretion in beta-cells.
Shen ZQ, Chiu WT, Kao CH, Chen YC, Chen LH, Teng TW, Hsiung SY, Tzeng TY, Tung CY, Juan CC, Tsai TF. Shen ZQ, et al. Mol Metab. 2025 Jun;96:102140. doi: 10.1016/j.molmet.2025.102140. Epub 2025 Apr 4. Mol Metab. 2025. PMID: 40189101 Free PMC article.
RESULTS: Four findings are pinpointed. Firstly, beta-cell specific Cisd2KO in mice disrupts systemic glucose homeostasis via impairing beta-granules synthesis and insulin secretion; hypertrophy of the beta-islets and the presence of a loss of id …
RESULTS: Four findings are pinpointed. Firstly, beta-cell specific Cisd2KO in mice disrupts systemic glucose homeostasis via …
Short telomeres compromise beta-cell signaling and survival.
Guo N, Parry EM, Li LS, Kembou F, Lauder N, Hussain MA, Berggren PO, Armanios M. Guo N, et al. PLoS One. 2011 Mar 10;6(3):e17858. doi: 10.1371/journal.pone.0017858. PLoS One. 2011. PMID: 21423765 Free PMC article.
In ex vivo studies, short telomeres induced cell-autonomous defects in beta-cells including reduced mitochondrial membrane hyperpolarization and Ca(2+) influx which limited insulin release. ...They implicate telomere length as a determinant of beta …
In ex vivo studies, short telomeres induced cell-autonomous defects in beta-cells including reduced mitochondrial membr …