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Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.
Abo A, Webb MR, Grogan A, Segal AW. Abo A, et al. Biochem J. 1994 Mar 15;298 Pt 3(Pt 3):585-91. doi: 10.1042/bj2980585. Biochem J. 1994. PMID: 8141770 Free PMC article.
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65.
Freeman JL, Abo A, Lambeth JD. Freeman JL, et al. Among authors: abo a. J Biol Chem. 1996 Aug 16;271(33):19794-801. doi: 10.1074/jbc.271.33.19794. J Biol Chem. 1996. PMID: 8702687
The biochemical basis of the NADPH oxidase of phagocytes.
Segal AW, Abo A. Segal AW, et al. Among authors: abo a. Trends Biochem Sci. 1993 Feb;18(2):43-7. doi: 10.1016/0968-0004(93)90051-n. Trends Biochem Sci. 1993. PMID: 8488557 Review.
Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558.
Chetty M, Thrasher AJ, Abo A, Casimir CM. Chetty M, et al. Among authors: abo a. Biochem J. 1995 Feb 15;306 ( Pt 1)(Pt 1):141-5. doi: 10.1042/bj3060141. Biochem J. 1995. PMID: 7864801 Free PMC article.
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Abo A, et al. Nature. 1991 Oct 17;353(6345):668-70. doi: 10.1038/353668a0. Nature. 1991. PMID: 1922386
Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.
Abo A, Boyhan A, West I, Thrasher AJ, Segal AW. Abo A, et al. J Biol Chem. 1992 Aug 25;267(24):16767-70. J Biol Chem. 1992. PMID: 1512217
Membrane association of Rac is required for high activity of the respiratory burst oxidase.
Kreck ML, Freeman JL, Abo A, Lambeth JD. Kreck ML, et al. Among authors: abo a. Biochemistry. 1996 Dec 10;35(49):15683-92. doi: 10.1021/bi962064l. Biochemistry. 1996. PMID: 8961931
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.
Diekmann D, Abo A, Johnston C, Segal AW, Hall A. Diekmann D, et al. Among authors: abo a. Science. 1994 Jul 22;265(5171):531-3. doi: 10.1126/science.8036496. Science. 1994. PMID: 8036496
Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.
Abo A, Pick E. Abo A, et al. J Biol Chem. 1991 Dec 15;266(35):23577-85. J Biol Chem. 1991. PMID: 1660877
We reported that ammonium sulfate fractionation (Pick, E., Kroizman, T., and Abo, A. (1989) J. Immunol. 143, 4180-4187) and affinity chromatography on 2',5'-ADP-agarose (Shaag, D., and Pick, E. (1990) Biochim. ...This requirement was evident whether sigma 1 was adde …
We reported that ammonium sulfate fractionation (Pick, E., Kroizman, T., and Abo, A. (1989) J. Immunol. 143, 4180-4187) and af …
Activation of the superoxide-forming NADPH oxidase of macrophages requires two cytosolic components--one of them is also present in certain nonphagocytic cells.
Pick E, Kroizman T, Abo A. Pick E, et al. Among authors: abo a. J Immunol. 1989 Dec 15;143(12):4180-7. J Immunol. 1989. PMID: 2556480
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