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Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo.
Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Chami N, et al. Among authors: aboussekhra a. Oral Microbiol Immunol. 2005 Apr;20(2):106-11. doi: 10.1111/j.1399-302X.2004.00202.x. Oral Microbiol Immunol. 2005. PMID: 15720571
In vivo, oral candidiasis in immunosuppressed rats was established by inoculating 3 x 10(8) cells of C. albicans with a cotton swab on three alternate days. ...Similar results were obtained with nystatin used as a reference treatment. CONCLUSION: The in vitro result …
In vivo, oral candidiasis in immunosuppressed rats was established by inoculating 3 x 10(8) cells of C. albicans with a cotton swab o …
Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway.
Islam SS, Al-Sharif I, Sultan A, Al-Mazrou A, Remmal A, Aboussekhra A. Islam SS, et al. Among authors: aboussekhra a. Mol Carcinog. 2018 Mar;57(3):333-346. doi: 10.1002/mc.22758. Epub 2017 Nov 24. Mol Carcinog. 2018. PMID: 29073729
To overcome these limitations, we combined eugenol, a natural polyphenolic molecule, with cisplatin to normalize cisplatin mediated toxicity and potential drug resistance. ...
To overcome these limitations, we combined eugenol, a natural polyphenolic molecule, with cisplatin to normalize cisplatin mediated t …
Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer.
Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Noman AS, et al. Among authors: aboussekhra a. Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4. Sci Rep. 2017. PMID: 28496132 Free PMC article.
The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. Further studies are warr …
The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recur …
p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.
Al-Ansari MM, Hendrayani SF, Shehata AI, Aboussekhra A. Al-Ansari MM, et al. Among authors: aboussekhra a. Oncogene. 2013 May 2;32(18):2356-64. doi: 10.1038/onc.2012.270. Epub 2012 Jul 2. Oncogene. 2013. PMID: 22751126 Free PMC article.
Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh.
Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS. Noman AS, et al. Among authors: aboussekhra a. Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830. Sci Rep. 2016. PMID: 26727947 Free PMC article.
High levels of Shh were observed in a subset of BC tumors with poor prognostic pathological features. Higher level of Shh expression correlated with a significantly poorer overall survival of patients compared with patients whose tumors expressed a low level …
High levels of Shh were observed in a subset of BC tumors with poor prognostic pathological features. Higher level of Shh expression …
The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.
Al-Moghrabi N, Nofel A, Al-Yousef N, Madkhali S, Bin Amer SM, Alaiya A, Shinwari Z, Al-Tweigeri T, Karakas B, Tulbah A, Aboussekhra A. Al-Moghrabi N, et al. Among authors: aboussekhra a. BMC Cancer. 2014 Nov 17;14:830. doi: 10.1186/1471-2407-14-830. BMC Cancer. 2014. PMID: 25403427 Free PMC article.
Furthermore, we have shown that the carriers exhibited a unique plasma protein pattern different from those of BC patients and controls, with 10 proteins similarly differentially expressed in patients and carriers as compared to controls. ...This informs the potential use …
Furthermore, we have shown that the carriers exhibited a unique plasma protein pattern different from those of BC patients and contro …
ATR suppresses the pro-tumorigenic functions of breast stromal fibroblasts.
Al-Ansari MM, Aboussekhra A. Al-Ansari MM, et al. Among authors: aboussekhra a. Oncotarget. 2018 Oct 5;9(78):34681-34690. doi: 10.18632/oncotarget.26159. eCollection 2018 Oct 5. Oncotarget. 2018. PMID: 30410668 Free PMC article.
Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts.
Al-Khalaf HH, Ghebeh H, Inass R, Aboussekhra A. Al-Khalaf HH, et al. Among authors: aboussekhra a. Mol Cell Biol. 2019 Jan 3;39(2):e00359-18. doi: 10.1128/MCB.00359-18. Print 2019 Jan 15. Mol Cell Biol. 2019. PMID: 30397077 Free PMC article.
Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects.
Al-Khalaf HH, Al-Harbi B, Al-Sayed A, Arafah M, Tulbah A, Jarman A, Al-Mohanna F, Aboussekhra A. Al-Khalaf HH, et al. Among authors: aboussekhra a. Mol Cell Biol. 2019 Jan 3;39(2):e00332-18. doi: 10.1128/MCB.00332-18. Print 2019 Jan 15. Mol Cell Biol. 2019. PMID: 30397072 Free PMC article.
Let-7b inhibits cancer-promoting effects of breast cancer-associated fibroblasts through IL-8 repression.
Al-Harbi B, Hendrayani SF, Silva G, Aboussekhra A. Al-Harbi B, et al. Among authors: aboussekhra a. Oncotarget. 2018 Apr 3;9(25):17825-17838. doi: 10.18632/oncotarget.24895. eCollection 2018 Apr 3. Oncotarget. 2018. PMID: 29707149 Free PMC article.
We present here clear evidence that let-7b, a tumor suppressor microRNA, plays key roles in the persistent activation of breast stromal fibroblasts and their functional interplay with cancer cells. ...These findings support targeting active stromal fibroblasts through rest …
We present here clear evidence that let-7b, a tumor suppressor microRNA, plays key roles in the persistent activation of breast strom …
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