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Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.
Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC. Hirsh AJ, et al. Among authors: abraham wm. J Pharmacol Exp Ther. 2008 Apr;325(1):77-88. doi: 10.1124/jpet.107.130443. Epub 2008 Jan 24. J Pharmacol Exp Ther. 2008. PMID: 18218832
Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.
Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J, Abraham WM, Boucher RC. Yerxa BR, et al. Among authors: abraham wm. J Pharmacol Exp Ther. 2002 Sep;302(3):871-80. doi: 10.1124/jpet.102.035485. J Pharmacol Exp Ther. 2002. PMID: 12183642
Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.
Coote K, Atherton-Watson HC, Sugar R, Young A, MacKenzie-Beevor A, Gosling M, Bhalay G, Bloomfield G, Dunstan A, Bridges RJ, Sabater JR, Abraham WM, Tully D, Pacoma R, Schumacher A, Harris J, Danahay H. Coote K, et al. Among authors: abraham wm. J Pharmacol Exp Ther. 2009 May;329(2):764-74. doi: 10.1124/jpet.108.148155. Epub 2009 Feb 3. J Pharmacol Exp Ther. 2009. PMID: 19190233 Free article.
The porcine lung as a potential model for cystic fibrosis.
Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. Rogers CS, et al. Among authors: abraham wm. Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18487356 Free PMC article. Review.
Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.
Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R. Terryah ST, et al. Among authors: abraham wm. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. Epub 2017 Oct 5. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 28982737 Free PMC article.
NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.
Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H. Coote KJ, et al. Among authors: abraham wm. Br J Pharmacol. 2015 Jun;172(11):2814-26. doi: 10.1111/bph.13075. Epub 2015 Apr 23. Br J Pharmacol. 2015. PMID: 25573195 Free PMC article.
Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion.
Tarran R, Sabater JR, Clarke TC, Tan CD, Davies CM, Liu J, Yeung A, Garland AL, Stutts MJ, Abraham WM, Phillips G, Baker WR, Wright CD, Wilbert S. Tarran R, et al. Among authors: abraham wm. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L746-56. doi: 10.1152/ajplung.00292.2012. Epub 2013 Mar 29. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23542952 Free PMC article.
220 results