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Page 1
Abrin poisoning.
Dickers KJ, Bradberry SM, Rice P, Griffiths GD, Vale JA. Dickers KJ, et al. Toxicol Rev. 2003;22(3):137-42. doi: 10.2165/00139709-200322030-00002. Toxicol Rev. 2003. PMID: 15181663 Review.
Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentional poisoning. ...At the cellular level, abrin inhibits protein synthesis, thereby causing cell death. Many of the features obse …
Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentiona …
Trends in the analysis of abrin poisoning for forensic purposes.
Sharma S, Kaur G, Kumar A, Singh R. Sharma S, et al. J Forensic Leg Med. 2023 Aug;98:102564. doi: 10.1016/j.jflm.2023.102564. Epub 2023 Jul 13. J Forensic Leg Med. 2023. PMID: 37459705 Review.
Abrus precatorius is a poisonous plant known since ancient times. Accidental poisoning is more common due to the intake of plant seeds containing deadly abrin which is a highly toxic and a thermolabile plant toxalbumin. ...The identification of this toxalbumi …
Abrus precatorius is a poisonous plant known since ancient times. Accidental poisoning is more common due to the intake of pla …
Fatal abrin poisoning by injection.
Rinner GR, Watkins SA, Shirazi FM, Fernández MC, Hess G, Mihalic J, Runcorn S, Waddell V, Ritter J, Reagan-Steiner S, Thomas J, Yip L, Walter FG. Rinner GR, et al. Clin Toxicol (Phila). 2021 Feb;59(2):169-171. doi: 10.1080/15563650.2020.1771360. Epub 2020 Jun 1. Clin Toxicol (Phila). 2021. PMID: 32475191
We describe the clinical course, laboratory, and pathologic findings in a case of fatal human poisoning associated with abrin injection. The Abrus precatorius seeds in this case were obtained via the internet. The Centers for Disease Control and Prevention's Laborat …
We describe the clinical course, laboratory, and pathologic findings in a case of fatal human poisoning associated with abrin …
Characterization of Lung Injury following Abrin Pulmonary Intoxication in Mice: Comparison to Ricin Poisoning.
Sapoznikov A, Gal Y, Alcalay R, Evgy Y, Sabo T, Kronman C, Falach R. Sapoznikov A, et al. Toxins (Basel). 2022 Sep 2;14(9):614. doi: 10.3390/toxins14090614. Toxins (Basel). 2022. PMID: 36136552 Free PMC article.
In this study, we conducted an in-depth comparison between the kinetics of in vivo abrin and ricin intoxication in a murine model. The data demonstrated differential binding of abrin and ricin to the parenchymal cells of the lungs. ...Furthermore, unlike following r …
In this study, we conducted an in-depth comparison between the kinetics of in vivo abrin and ricin intoxication in a murine model. Th …
Abrin poisoning in an 18-month-old child.
Alhamdani M, Brown B, Narula P. Alhamdani M, et al. Am J Case Rep. 2015 Mar 10;16:146-8. doi: 10.12659/AJCR.892917. Am J Case Rep. 2015. PMID: 25754813 Free PMC article.
BACKGROUND: When discussing known poisons and their clinical consequences, few physicians are aware of the deadly poison abrin. ...The parents had assumed the child was suffering from a severe gastroenteritis until they noticed 3 consecutive diapers containin …
BACKGROUND: When discussing known poisons and their clinical consequences, few physicians are aware of the deadly poison ab …
Gaps in forensic toxicological analysis: The veiled abrin.
Chen Y, Liu J, Song T, Zou X, Li L, Nie Q, Zhang P. Chen Y, et al. Toxicon. 2024 May 6;242:107684. doi: 10.1016/j.toxicon.2024.107684. Epub 2024 Mar 19. Toxicon. 2024. PMID: 38513827 Review.
Abrin poisoning can be utilized to cause accidents, suicides, and homicides, which necessitates attention from clinicians and forensic scientists. ...Additionally, the evidence on abrin in the field of forensic toxicology and forensic pathology is discussed. …
Abrin poisoning can be utilized to cause accidents, suicides, and homicides, which necessitates attention from clinicians and …
Mapping Immunodominant Antibody Epitopes of Abrin.
Alcalay R, Falach R, Gal Y, Sapoznikov A, Sabo T, Kronman C, Mazor O. Alcalay R, et al. Antibodies (Basel). 2020 Apr 27;9(2):11. doi: 10.3390/antib9020011. Antibodies (Basel). 2020. PMID: 32349421 Free PMC article.
To date, there is no effective postexposure treatment for abrin poisoning, and efforts are being made to develop an efficient vaccine and measures for postexposure therapy. ...Aiming to identify the immunodominant epitopes of abrin, several neutralizing antia …
To date, there is no effective postexposure treatment for abrin poisoning, and efforts are being made to develop an efficient …
A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo.
Peng J, Wu J, Shi N, Xu H, Luo L, Wang J, Li X, Xiao H, Feng J, Li X, Chai L, Qiao C. Peng J, et al. Front Immunol. 2022 Feb 4;13:831536. doi: 10.3389/fimmu.2022.831536. eCollection 2022. Front Immunol. 2022. PMID: 35185923 Free PMC article.
Currently, no effective agents have been reported to treat abrin poisoning. In this study, a novel anti-abrin neutralizing antibody (S008) was humanized using computer-aided design, which possessed lower immunogenicity. ...S008 was found that it did not inhib …
Currently, no effective agents have been reported to treat abrin poisoning. In this study, a novel anti-abrin neutraliz …
Correlation of abrin-mediated inhibition of protein synthesis and apoptosis.
Tiwari V, Karande AA. Tiwari V, et al. IUBMB Life. 2019 Mar;71(3):357-363. doi: 10.1002/iub.1980. Epub 2018 Dec 2. IUBMB Life. 2019. PMID: 30506989 Free article.
Abrin was also observed to cause direct DNA damage in KB cells, while in Ovcar-3 cells abrin-induced DNA damage was found to be dependent on caspases. Overall, the study demonstrates that the correlation of abrin-mediated PSI and apoptosis is cell-specific an …
Abrin was also observed to cause direct DNA damage in KB cells, while in Ovcar-3 cells abrin-induced DNA damage was found to b …
Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report.
Huang J, Zhang W, Li X, Feng S, Ye G, Wei H, Gong X. Huang J, et al. Medicine (Baltimore). 2017 Jul;96(27):e7423. doi: 10.1097/MD.0000000000007423. Medicine (Baltimore). 2017. PMID: 28682903 Free PMC article.
LESSONS: The combination of CRRT and HP is an efficient measure in the treatment of abrin poisoning for which there is no specific antidote. This is the first reported case of an abrin poisoning patient successfully treated by CRRT plus HP. Our experie …
LESSONS: The combination of CRRT and HP is an efficient measure in the treatment of abrin poisoning for which there is no spec …
226 results