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Absorption of oral progesterone is influenced by vehicle and particle size.
Hargrove JT, Maxson WS, Wentz AC. Hargrove JT, et al. Am J Obstet Gynecol. 1989 Oct;161(4):948-51. doi: 10.1016/0002-9378(89)90759-x. Am J Obstet Gynecol. 1989. PMID: 2801843
The oral route of progesterone administration has long been considered impractical because of poor absorption and short biologic half-life. Recent reports suggest that micronization of progesterone enhances absorption and increases serum and tis …
The oral route of progesterone administration has long been considered impractical because of poor absorption and short …
Spray dried progesterone formulations for carrier free dry powder inhalation.
Hibbard T, Mitchell H, Kim Y, Shankland K, Al-Obaidi H. Hibbard T, et al. Eur J Pharm Biopharm. 2023 Aug;189:264-275. doi: 10.1016/j.ejpb.2023.06.018. Epub 2023 Jun 29. Eur J Pharm Biopharm. 2023. PMID: 37392870 Free article.
Low oral absorption and extensive first pass metabolism of progesterone is reported for many oral formulations which warrants investigation into other routes of administration. ...However, further optimisation of formulations was required to direct mor …
Low oral absorption and extensive first pass metabolism of progesterone is reported for many oral formulations w …
Rectal drug administration: clinical pharmacokinetic considerations.
de Boer AG, Moolenaar F, de Leede LG, Breimer DD. de Boer AG, et al. Clin Pharmacokinet. 1982 Jul-Aug;7(4):285-311. doi: 10.2165/00003088-198207040-00002. Clin Pharmacokinet. 1982. PMID: 6126289 Review.
Drawbacks of rectal drug administration include the interruption of absorption by defaecation and lack of patient acceptability. The mechanism of drug absorption from the rectum is probably no different to that in the upper part of the gastrointestinal tract, despit …
Drawbacks of rectal drug administration include the interruption of absorption by defaecation and lack of patient acceptability. The …
Are Nanostructured Lipid Carriers (NLC) better than Solid Lipid Nanoparticles (SLN) for delivering abiraterone acetate through the gastrointestinal tract?
Lemasson O, Briançon S, Bourgeaux V, Guichard M, Valour JP, Moret GA, Bourgeois S. Lemasson O, et al. Int J Pharm. 2024 Dec 25;667(Pt B):124869. doi: 10.1016/j.ijpharm.2024.124869. Epub 2024 Oct 26. Int J Pharm. 2024. PMID: 39490790
Abiraterone acetate (AbA) is a progesterone derivative indicated for the treatment of metastatic prostate cancer. This BCS (Biopharmaceutics Classification System) Class IV molecule has an extremely poor oral bioavailability (<10 %), notably due to its very low w …
Abiraterone acetate (AbA) is a progesterone derivative indicated for the treatment of metastatic prostate cancer. This BCS (Biopharma …