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PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial.
Misra H, Lickliter J, Kazo F, Abuchowski A. Misra H, et al. Among authors: abuchowski a. Artif Organs. 2014 Aug;38(8):702-7. doi: 10.1111/aor.12341. Epub 2014 Aug 12. Artif Organs. 2014. PMID: 25113835 Clinical Trial.
Microvascular and Systemic Impact of Resuscitation with PEGylated Carboxyhemoglobin-Based Oxygen Carrier or Hetastarch in a Rat Model of Transient Hemorrhagic Shock.
Nugent WH, Sheppard FR, Dubick MA, Cestero RF, Darlington DN, Jubin R, Abuchowski A, Song BK. Nugent WH, et al. Among authors: abuchowski a. Shock. 2020 Apr;53(4):493-502. doi: 10.1097/SHK.0000000000001370. Shock. 2020. PMID: 31045989
Pharmacologically increasing collateral perfusion during acute stroke using a carboxyhemoglobin gas transfer agent (Sanguinate™) in spontaneously hypertensive rats.
Cipolla MJ, Linfante I, Abuchowski A, Jubin R, Chan SL. Cipolla MJ, et al. Among authors: abuchowski a. J Cereb Blood Flow Metab. 2018 May;38(5):755-766. doi: 10.1177/0271678X17705567. Epub 2017 Apr 24. J Cereb Blood Flow Metab. 2018. PMID: 28436705 Free PMC article.
Effects of Sanguinate on Systemic and Microcirculatory Variables in a Model of Prolonged Hemorrhagic Shock.
Nugent WH, Cestero RF, Ward K, Jubin R, Abuchowski A, Song BK. Nugent WH, et al. Among authors: abuchowski a. Shock. 2019 Oct;52(1S Suppl 1):108-115. doi: 10.1097/SHK.0000000000001082. Shock. 2019. PMID: 29252939 Free PMC article.
Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.
Klaus JA, Kibler KK, Abuchowski A, Koehler RC. Klaus JA, et al. Artif Cells Blood Substit Immobil Biotechnol. 2010 Oct;38(5):223-9. doi: 10.3109/10731199.2010.488635. Artif Cells Blood Substit Immobil Biotechnol. 2010. PMID: 20486873 Free PMC article.
Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice.
Ananthakrishnan R, Li Q, O'Shea KM, Quadri N, Wang L, Abuchowski A, Schmidt AM, Ramasamy R. Ananthakrishnan R, et al. Artif Cells Nanomed Biotechnol. 2013 Dec;41(6):428-36. doi: 10.3109/21691401.2012.762370. Epub 2013 Jan 23. Artif Cells Nanomed Biotechnol. 2013. PMID: 23342967
This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute coronary syndromes....
This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute …
A phase Ib, open-label, single arm study to assess the safety, pharmacokinetics, and impact on humoral sensitization of SANGUINATE infusion in patients with end-stage renal disease.
Abu Jawdeh BG, Woodle ES, Leino AD, Brailey P, Tremblay S, Dorst T, Abdallah MH, Govil A, Byczkowski D, Misra H, Abuchowski A, Alloway RR. Abu Jawdeh BG, et al. Among authors: abuchowski a. Clin Transplant. 2018 Jan;32(1). doi: 10.1111/ctr.13155. Epub 2017 Dec 4. Clin Transplant. 2018. PMID: 29140548 Clinical Trial.
A Phase I study to determine safety, pharmacokinetics, and pharmacodynamics of ANF-RHO™, a novel PEGylated granulocyte colony-stimulating factor, in healthy volunteers.
Misra H, Berryman J, Jubin R, Abuchowski A. Misra H, et al. Among authors: abuchowski a. Invest New Drugs. 2018 Feb;36(1):75-84. doi: 10.1007/s10637-017-0490-8. Epub 2017 Jul 28. Invest New Drugs. 2018. PMID: 28752433 Clinical Trial.
A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia.
Misra H, Bainbridge J, Berryman J, Abuchowski A, Galvez KM, Uribe LF, Hernandez AL, Sosa NR. Misra H, et al. Among authors: abuchowski a. Rev Bras Hematol Hemoter. 2017 Jan-Mar;39(1):20-27. doi: 10.1016/j.bjhh.2016.08.004. Epub 2016 Oct 20. Rev Bras Hematol Hemoter. 2017. PMID: 28270341 Free PMC article.
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