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Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation.
Salvi N, Abyzov A, Blackledge M. Salvi N, et al. Among authors: abyzov a. J Phys Chem Lett. 2016 Jul 7;7(13):2483-9. doi: 10.1021/acs.jpclett.6b00885. Epub 2016 Jun 20. J Phys Chem Lett. 2016. PMID: 27300592
Nuclear magnetic resonance (NMR) relaxation rates contain a wealth of information about the time scales and amplitudes of motion in IDPs, but the highly dynamic nature of IDPs complicates their interpretation. We present a novel framework in which a series of …
Nuclear magnetic resonance (NMR) relaxation rates contain a wealth of information about the time scales and amplitudes of motion in I …
Identification of Dynamic Modes in an Intrinsically Disordered Protein Using Temperature-Dependent NMR Relaxation.
Abyzov A, Salvi N, Schneider R, Maurin D, Ruigrok RW, Jensen MR, Blackledge M. Abyzov A, et al. J Am Chem Soc. 2016 May 18;138(19):6240-51. doi: 10.1021/jacs.6b02424. Epub 2016 May 6. J Am Chem Soc. 2016. PMID: 27112095
Fast (τ ≤ 50 ps) components report on librational motions, a dominant mode occurs on time scales around 1 ns, apparently reporting on backbone sampling within Ramachandran substates, while a slower component (5-25 ns) reports on segmental dynamics dominated by the c …
Fast (τ ≤ 50 ps) components report on librational motions, a dominant mode occurs on time scales around 1 ns, apparently reporting on …
Analytical Description of NMR Relaxation Highlights Correlated Dynamics in Intrinsically Disordered Proteins.
Salvi N, Abyzov A, Blackledge M. Salvi N, et al. Among authors: abyzov a. Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14020-14024. doi: 10.1002/anie.201706740. Epub 2017 Sep 14. Angew Chem Int Ed Engl. 2017. PMID: 28834051
Combining molecular dynamics simulation and NMR, we introduce a framework in which distinct motions are attributed to local libration, backbone dihedral angle dynamics and longer-range tumbling of one or more peptide planes. ...
Combining molecular dynamics simulation and NMR, we introduce a framework in which distinct motions are attributed to local libration …
Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation.
Salvi N, Abyzov A, Blackledge M. Salvi N, et al. Among authors: abyzov a. Prog Nucl Magn Reson Spectrosc. 2017 Nov;102-103:43-60. doi: 10.1016/j.pnmrs.2017.06.001. Epub 2017 Jul 10. Prog Nucl Magn Reson Spectrosc. 2017. PMID: 29157493 Review.
IDPs represent a significant fraction of all proteomes, and, despite their importance for understanding fundamental biological processes, the molecular basis of their activity still remains largely unknown. ...
IDPs represent a significant fraction of all proteomes, and, despite their importance for understanding fundamental biological proces …
Solvent-dependent segmental dynamics in intrinsically disordered proteins.
Salvi N, Abyzov A, Blackledge M. Salvi N, et al. Among authors: abyzov a. Sci Adv. 2019 Jun 28;5(6):eaax2348. doi: 10.1126/sciadv.aax2348. eCollection 2019 Jun. Sci Adv. 2019. PMID: 31259246 Free PMC article.
A Unified Description of Intrinsically Disordered Protein Dynamics under Physiological Conditions Using NMR Spectroscopy.
Adamski W, Salvi N, Maurin D, Magnat J, Milles S, Jensen MR, Abyzov A, Moreau CJ, Blackledge M. Adamski W, et al. Among authors: abyzov a. J Am Chem Soc. 2019 Nov 6;141(44):17817-17829. doi: 10.1021/jacs.9b09002. Epub 2019 Oct 22. J Am Chem Soc. 2019. PMID: 31591893
LongAGE: defining breakpoints of genomic structural variants through optimal and memory efficient alignments of long reads.
Tran Q, Abyzov A. Tran Q, et al. Among authors: abyzov a. Bioinformatics. 2020 Aug 10:btaa703. doi: 10.1093/bioinformatics/btaa703. Online ahead of print. Bioinformatics. 2020. PMID: 32777815
PsychENCODE and beyond: transcriptomics and epigenomics of brain development and organoids.
Jourdon A, Scuderi S, Capauto D, Abyzov A, Vaccarino FM. Jourdon A, et al. Among authors: abyzov a. Neuropsychopharmacology. 2020 Jul 13. doi: 10.1038/s41386-020-0763-3. Online ahead of print. Neuropsychopharmacology. 2020. PMID: 32659782 Review.
The role of somatic mosaicism in brain disease.
Jourdon A, Fasching L, Scuderi S, Abyzov A, Vaccarino FM. Jourdon A, et al. Among authors: abyzov a. Curr Opin Genet Dev. 2020 Jul 1;65:84-90. doi: 10.1016/j.gde.2020.05.002. Online ahead of print. Curr Opin Genet Dev. 2020. PMID: 32622340 Review.
Cell Lineage Tracing and Cellular Diversity in Humans.
Abyzov A, Vaccarino FM. Abyzov A, et al. Annu Rev Genomics Hum Genet. 2020 Aug 31;21:101-116. doi: 10.1146/annurev-genom-083118-015241. Epub 2020 May 15. Annu Rev Genomics Hum Genet. 2020. PMID: 32413272
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