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2014 1105
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41,058 results

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The following terms were not found in PubMed: inhibition+Didehydrostemofoline+Stemofoline+Stemona, collinsiae+Stemonaceae
Page 1
Acetylcholinesterase: A Primary Target for Drugs and Insecticides.
Thapa S, Lv M, Xu H. Thapa S, et al. Mini Rev Med Chem. 2017;17(17):1665-1676. doi: 10.2174/1389557517666170120153930. Mini Rev Med Chem. 2017. PMID: 28117022 Review.
BACKGROUND: Acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. ...Besides, the review also presents an overview about the resistance mechanism that the organisms develo …
BACKGROUND: Acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzin …
Acetylcholinesterase: how is structure related to function?
Silman I, Sussman JL. Silman I, et al. Chem Biol Interact. 2008 Sep 25;175(1-3):3-10. doi: 10.1016/j.cbi.2008.05.035. Epub 2008 Jun 6. Chem Biol Interact. 2008. PMID: 18586019 Review.
In accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. Solution of its three-dimensional structure revealed …
In accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter …
Computational Studies on Acetylcholinesterases.
Xu Y, Cheng S, Sussman JL, Silman I, Jiang H. Xu Y, et al. Molecules. 2017 Aug 10;22(8):1324. doi: 10.3390/molecules22081324. Molecules. 2017. PMID: 28796192 Free PMC article. Review.
This is especially the case in a gated diffusion-controlled reaction catalyzed by an enzyme such as acetylcholinesterase. The catalytic triad of acetylcholinesterase is located at the bottom of a long and narrow gorge, but it catalyzes the extremely rapid hydrolysis …
This is especially the case in a gated diffusion-controlled reaction catalyzed by an enzyme such as acetylcholinesterase. The catalyt …
Acetylcholinesterases.
Trevor AJ, Gordon MA, Parker KK, Chan SL. Trevor AJ, et al. Life Sci. 1978 Sep 25;23(12):1209-20. doi: 10.1016/0024-3205(78)90498-8. Life Sci. 1978. PMID: 362101 Review. No abstract available.
Current acetylcholinesterase-inhibitors: a neuroinformatics perspective.
Shaikh S, Verma A, Siddiqui S, Ahmad SS, Rizvi SM, Shakil S, Biswas D, Singh D, Siddiqui MH, Shakil S, Tabrez S, Kamal MA. Shaikh S, et al. CNS Neurol Disord Drug Targets. 2014 Apr;13(3):391-401. doi: 10.2174/18715273113126660166. CNS Neurol Disord Drug Targets. 2014. PMID: 24059296 Review.
This review presents a concise update on the inhibitors of the neuroenzyme, acetylcholinesterase (AChE; EC 3.1.1.7). AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. ...
This review presents a concise update on the inhibitors of the neuroenzyme, acetylcholinesterase (AChE; EC 3.1.1.7). AChE is a serine …
A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease.
Kumar M, Bansal N. Kumar M, et al. Curr Drug Targets. 2022;23(5):486-512. doi: 10.2174/1389450122666211118125233. Curr Drug Targets. 2022. PMID: 34792002 Review.
Most of the current therapeutic strategies focus on modulation of a single target, e.g., inhibition of acetylcholinesterase, glutamate excitotoxicity (memantine), or nootropics (piracetam), even though AD is a multifaceted neurological disorder. ...
Most of the current therapeutic strategies focus on modulation of a single target, e.g., inhibition of acetylcholinesterase, glutamat …
Acetylcholinesterase Activity Staining in Freshwater Planarians.
Rabeler C, Gong T, Ireland D, Cochet-Escartin O, Collins ES. Rabeler C, et al. Curr Protoc. 2023 Feb;3(2):e674. doi: 10.1002/cpz1.674. Curr Protoc. 2023. PMID: 36799654 Free PMC article.
The serine hydrolase acetylcholinesterase (AChE) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. ...Basic Protocol 1: Preparing the staining solution Basic Protocol 2: Fixing, staining, and imag …
The serine hydrolase acetylcholinesterase (AChE) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitt …
The multiple biological roles of the cholinesterases.
Silman I. Silman I. Prog Biophys Mol Biol. 2021 Jul;162:41-56. doi: 10.1016/j.pbiomolbio.2020.12.001. Epub 2020 Dec 8. Prog Biophys Mol Biol. 2021. PMID: 33307019 Review.
The rapid hydrolysis of acetylcholine by acetylcholinesterase generates high local proton concentrations. The possible biophysical and biological consequences of this effect are discussed. The biological significance of the acetylcholinesterases secreted by parasiti …
The rapid hydrolysis of acetylcholine by acetylcholinesterase generates high local proton concentrations. The possible biophysical an …
Acetylcholinesterase in Alzheimer's disease.
Talesa VN. Talesa VN. Mech Ageing Dev. 2001 Nov;122(16):1961-9. doi: 10.1016/s0047-6374(01)00309-8. Mech Ageing Dev. 2001. PMID: 11589914 Review.
Since the discovery of the cholinergic deficit in Alzheimer disease (AD), acetylcholinesterase (AChE) has been widely investigated in tissues involved in the disease. These studies showed modifications in AChE activity and changes in its polymorphism in brain as well as in …
Since the discovery of the cholinergic deficit in Alzheimer disease (AD), acetylcholinesterase (AChE) has been widely investigated in …
Structure and function of acetylcholinesterase.
Leuzinger W. Leuzinger W. Prog Brain Res. 1969;31:241-5. doi: 10.1016/S0079-6123(08)63242-2. Prog Brain Res. 1969. PMID: 4899409 Review. No abstract available.
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