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Translational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro-in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques.
Al Feteisi H, Achour B, Rostami-Hodjegan A, Barber J. Al Feteisi H, et al. Among authors: achour b. Expert Opin Drug Metab Toxicol. 2015;11(9):1357-69. doi: 10.1517/17425255.2015.1055245. Epub 2015 Jun 26. Expert Opin Drug Metab Toxicol. 2015. PMID: 26108733 Review.
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.
Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G; Amin Rostami-Hodjegan. Harwood MD, et al. Among authors: achour b. Drug Metab Dispos. 2016 Mar;44(3):297-307. doi: 10.1124/dmd.115.067371. Epub 2015 Dec 2. Drug Metab Dispos. 2016. PMID: 26631742
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.
Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G, Rostami-Hodjegan A. Harwood MD, et al. Among authors: achour b. Drug Metab Dispos. 2016 Mar;44(3):476-80. doi: 10.1124/dmd.115.067777. Epub 2016 Feb 3. Drug Metab Dispos. 2016. PMID: 26842595
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