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The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa).
Wuttke W, Jarry H, Haunschild J, Stecher G, Schuh M, Seidlova-Wuttke D. Wuttke W, et al. J Steroid Biochem Mol Biol. 2014 Jan;139:302-10. doi: 10.1016/j.jsbmb.2013.02.007. Epub 2013 Feb 28. J Steroid Biochem Mol Biol. 2014. PMID: 23459142 Review.
Extracts of the rhizome of black cohosh (Cimicifuga racemosa=CR) did not bind to estrogen receptors and were shown to be devoid of estrogenic effects on mammary cancer cells in vitro and on mammary gland and uterine histology in ovariectomized rats. ...This was most …
Extracts of the rhizome of black cohosh (Cimicifuga racemosa=CR) did not bind to estrogen receptors and were shown to be devoi …
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence.
Castelo-Branco C, Gambacciani M, Cano A, Minkin MJ, Rachoń D, Ruan X, Beer AM, Schnitker J, Henneicke-von Zepelin HH, Pickartz S. Castelo-Branco C, et al. Climacteric. 2021 Apr;24(2):109-119. doi: 10.1080/13697137.2020.1820477. Epub 2020 Oct 6. Climacteric. 2021. PMID: 33021111 Free article.
A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with isopropanolic Cimicifuga racemosa extract (iCR). Compared to placebo, iCR was significantly superior for treating neurovegeta …
A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with …
Black cohosh.
Kligler B. Kligler B. Am Fam Physician. 2003 Jul 1;68(1):114-6. Am Fam Physician. 2003. PMID: 12887117 Free article. Review.
The herb black cohosh, or Actaea racemosa (formerly named Cimicifuga racemosa), is native to North America. The roots and rhizomes of this herb are widely used in the treatment of menopausal symptoms and menstrual dysfunction. ...
The herb black cohosh, or Actaea racemosa (formerly named Cimicifuga racemosa), is native to North America. The …
Black cohosh (Actaea/Cimicifuga racemosa): review of the clinical data for safety and efficacy in menopausal symptoms.
Mahady GB. Mahady GB. Treat Endocrinol. 2005;4(3):177-84. doi: 10.2165/00024677-200504030-00006. Treat Endocrinol. 2005. PMID: 15898823 Review.
Since the publication of the results of the Women's Health Initiative that described the risks of hormone replacement therapy, many women are actively seeking alternative treatments for menopausal symptoms. Black cohosh (Actaea racemosa, syn. Cimicifuga ra …
Since the publication of the results of the Women's Health Initiative that described the risks of hormone replacement therapy, many women ar …
The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa).
Huntley A. Huntley A. Expert Opin Drug Saf. 2004 Nov;3(6):615-23. doi: 10.1517/14740338.3.6.615. Expert Opin Drug Saf. 2004. PMID: 15500420 Review.
Black cohosh (Actaea racemosa/Cimicifuga racemosa) is a North American perennial plant that has been used for traditional medicinal purposes by the native Indian population. ...
Black cohosh (Actaea racemosa/Cimicifuga racemosa) is a North American perennial plant that has been used for tr …
Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis.
Sadahiro R, Matsuoka LN, Zeng BS, Chen KH, Zeng BY, Wang HY, Chu CS, Stubbs B, Su KP, Tu YK, Wu YC, Lin PY, Chen TY, Chen YW, Suen MW, Hopwood M, Yang WC, Sun CK, Cheng YS, Shiue YL, Hung CM, Matsuoka YJ, Tseng PT. Sadahiro R, et al. Menopause. 2023 Jul 1;30(7):766-773. doi: 10.1097/GME.0000000000002196. Epub 2023 May 16. Menopause. 2023. PMID: 37192826
Ethnobotany, Phytochemistry, Traditional and Modern Uses of Actaea racemosa L. (Black cohosh): A Review.
Salari S, Amiri MS, Ramezani M, Moghadam AT, Elyasi S, Sahebkar A, Emami SA. Salari S, et al. Adv Exp Med Biol. 2021;1308:403-449. doi: 10.1007/978-3-030-64872-5_24. Adv Exp Med Biol. 2021. PMID: 33861455 Review.
Actaea racemosa (AR) also known as Cimicifuga racemosa, is a perennial plant from Ranunculaceae family which was used as traditional remedies in treatment of various condition like rheumatoid muscular pain, headache, inflammation and dysmenorrhea. A …
Actaea racemosa (AR) also known as Cimicifuga racemosa, is a perennial plant from Ranunculaceae family which was …
Cimicifuga racemosa extract Ze 450 shifts macrophage immunometabolism and attenuates pro-inflammatory signaling.
Günther M, Paczia N, Michels S, Fiebich BL, Vogt S, Drewe J, Boonen G, Butterweck V, Culmsee C. Günther M, et al. Biomed Pharmacother. 2025 Jul;188:118130. doi: 10.1016/j.biopha.2025.118130. Epub 2025 May 17. Biomed Pharmacother. 2025. PMID: 40382826 Free article.
Extracts from the rhizomes of Cimicifuga racemosa (CRE) are well-studied for treating climacteric symptoms and considered as a safe alternative to hormone replacement therapy (HRT). ...In this study, we aimed to investigate the effects of Cimicifuga racemo …
Extracts from the rhizomes of Cimicifuga racemosa (CRE) are well-studied for treating climacteric symptoms and considered as a …
Cimicifuga foetida and C. racemosa prevent postmenopausal osteoporosis by inhibiting autophagy of osteoclasts via CB2R and ERalpha.
Hu SJ, Zhao ZH, Chen GC, Shan MY, Shen Y, Song ZL, Zhao QM, Cheng G, Zhang QL, Han T, Zhang QY, Qin LP. Hu SJ, et al. Phytomedicine. 2025 Sep;145:157073. doi: 10.1016/j.phymed.2025.157073. Epub 2025 Jul 13. Phytomedicine. 2025. PMID: 40680333
BACKGROUND: Cannabinoid receptor type 2 (CB2R) and estrogen receptor alpha (ERalpha) activators have been shown to possess remarkable regulatory effects on bone metabolism. Cimicifuga foetida l. (CF), the same genus plant as Cimicifuga racemosa (l.) Nutt. (CR …
BACKGROUND: Cannabinoid receptor type 2 (CB2R) and estrogen receptor alpha (ERalpha) activators have been shown to possess remarkable regula …
Pharmacological effects of Cimicifuga racemosa.
Borrelli F, Izzo AA, Ernst E. Borrelli F, et al. Life Sci. 2003 Jul 25;73(10):1215-29. doi: 10.1016/s0024-3205(03)00378-3. Life Sci. 2003. PMID: 12850238
Cimicifuga racemosa is widely employed to relieve menopause symptoms for its hormonal-like action. ...A total of 15 animal and 15 in vitro studies on C. racemosa have been found. Their results suggest that C. racemosa possesses a central activity inste …
Cimicifuga racemosa is widely employed to relieve menopause symptoms for its hormonal-like action. ...A total of 15 animal and …
896 results