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1960 1
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16 results

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Page 1
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL. Chen AC, et al. N Engl J Med. 2015 Oct 22;373(17):1618-26. doi: 10.1056/NEJMoa1506197. N Engl J Med. 2015. PMID: 26488693 Free article. Clinical Trial.
Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic keratoses during the 12-month intervention period, the number of nonmelanoma skin cancers in the 6-month postintervention period, and the saf …
Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic k …
Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, Gin D, Sidhu S, Paddon VL, Banney LA, Lim A, Upjohn E, Schaider H, Ganhewa AD, Nguyen J, McKenzie CA, Prakash S, McLean C, Lochhead A, Ibbetson J, Dettrick A, Landgren A, Allnutt KJ, Allison C, Davenport RB, Mumford BP, Wong B, Stagg B, Tedman A, Gribbin H, Edwards HA, De Rosa N, Stewart T, Doolan BJ, Kok Y, Simpson K, Low ZM, Kovitwanichkanont T, Scolyer RA, Dhillon HM, Vardy JL, Chadban SJ, Bowen DG, Chen AC, Damian DL. Allen NC, et al. N Engl J Med. 2023 Mar 2;388(9):804-812. doi: 10.1056/NEJMoa2203086. N Engl J Med. 2023. PMID: 36856616 Clinical Trial.
No significant between-group differences in squamous-cell and basal-cell carcinoma counts, actinic keratosis counts, or quality-of-life scores were observed. Adverse events and changes in blood or urine laboratory variables were similar in the two groups. CONCLUSION …
No significant between-group differences in squamous-cell and basal-cell carcinoma counts, actinic keratosis counts, or qualit …
Comparing the efficacy of field treatments for actinic keratosis: a critical appraisal of a randomized trial in the New England Journal of Medicine.
Wehner MR. Wehner MR. Br J Dermatol. 2020 Jun;182(6):1343-1344. doi: 10.1111/bjd.18537. Epub 2020 Feb 3. Br J Dermatol. 2020. PMID: 31529471
AIM: Jansen et al. conducted a randomized trial to compare the efficacy of four field treatments for actinic keratosis (AK). SETTING AND DESIGN: This was a multicentre, single-blind, randomized trial conducted in the dermatology departments of four Netherlands hospi …
AIM: Jansen et al. conducted a randomized trial to compare the efficacy of four field treatments for actinic keratosis (AK). S …
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
Blauvelt A, Kempers S, Lain E, Schlesinger T, Tyring S, Forman S, Ablon G, Martin G, Wang H, Cutler DL, Fang J, Kwan MR; Phase 3 Tirbanibulin for Actinic Keratosis Group. Blauvelt A, et al. N Engl J Med. 2021 Feb 11;384(6):512-520. doi: 10.1056/NEJMoa2024040. N Engl J Med. 2021. PMID: 33567191 Clinical Trial.
CONCLUSIONS: In two identically designed trials, tirbanibulin 1% ointment applied once daily for 5 days was superior to vehicle for the treatment of actinic keratosis at 2 months but was associated with transient local reactions and recurrence of lesions at 1 year. …
CONCLUSIONS: In two identically designed trials, tirbanibulin 1% ointment applied once daily for 5 days was superior to vehicle for the trea …
Randomized Trial of Four Treatment Approaches for Actinic Keratosis.
Jansen MHE, Kessels JPHM, Nelemans PJ, Kouloubis N, Arits AHMM, van Pelt HPA, Quaedvlieg PJF, Essers BAB, Steijlen PM, Kelleners-Smeets NWJ, Mosterd K. Jansen MHE, et al. N Engl J Med. 2019 Mar 7;380(10):935-946. doi: 10.1056/NEJMoa1811850. N Engl J Med. 2019. PMID: 30855743 Clinical Trial.
BACKGROUND: Actinic keratosis is the most frequent premalignant skin disease in the white population. ...Patients with a clinical diagnosis of five or more actinic keratosis lesions on the head, involving one continuous area of 25 to 100 cm(2), were en …
BACKGROUND: Actinic keratosis is the most frequent premalignant skin disease in the white population. ...Patients with a clini …
Treatment Approaches for Actinic Keratosis.
Navarrete-Dechent C, Marchetti MA, Nehal KS. Navarrete-Dechent C, et al. N Engl J Med. 2019 Jun 6;380(23):2275. doi: 10.1056/NEJMc1904535. N Engl J Med. 2019. PMID: 31167064 No abstract available.
Effect of a low-fat diet on the incidence of actinic keratosis.
Black HS, Herd JA, Goldberg LH, Wolf JE Jr, Thornby JI, Rosen T, Bruce S, Tschen JA, Foreyt JP, Scott LW, et al. Black HS, et al. N Engl J Med. 1994 May 5;330(18):1272-5. doi: 10.1056/NEJM199405053301804. N Engl J Med. 1994. PMID: 8145782 Free article. Clinical Trial.
Studies in animals have shown that dietary fat influences the incidence of sun-induced skin cancer, but the effect of diet on the incidence of actinic keratosis in humans is not known. METHODS: We randomly assigned 76 patients with nonmelanoma skin cancer either to …
Studies in animals have shown that dietary fat influences the incidence of sun-induced skin cancer, but the effect of diet on the incidence …
Treatment Approaches for Actinic Keratosis. Reply.
Jansen MHE, Kelleners-Smeets NWJ, Mosterd K. Jansen MHE, et al. N Engl J Med. 2019 Jun 6;380(23):2275-2276. doi: 10.1056/NEJMc1904535. N Engl J Med. 2019. PMID: 31167065 No abstract available.
Nicotinamide for Skin-Cancer Chemoprevention.
Drago F, Ciccarese G, Parodi A. Drago F, et al. N Engl J Med. 2016 Feb 25;374(8):789-90. doi: 10.1056/NEJMc1514791. N Engl J Med. 2016. PMID: 26933858 No abstract available.
16 results