A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors.
Gosschalk JE, Chang C, Sue CK, Siegel SD, Wu C, Kattke MD, Yi SW, Damoiseaux R, Jung ME, Ton-That H, Clubb RT.
Gosschalk JE, et al.
Sci Rep. 2020 May 22;10(1):8520. doi: 10.1038/s41598-020-65256-x.
Sci Rep. 2020.
PMID: 32444661
Free PMC article.
To discover inhibitors that are effective in inactivating sortases in vivo, we developed and implemented a novel cell-based screen using Actinomyces oris, a key colonizer in the development of oral biofilms. A. oris is unique because it exhibits sortase-dependent gr …
To discover inhibitors that are effective in inactivating sortases in vivo, we developed and implemented a novel cell-based screen using …