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Phencyclidine inhibits the activity of thalamic reticular gamma-aminobutyric acidergic neurons in rat brain.
Troyano-Rodriguez E, Lladó-Pelfort L, Santana N, Teruel-Martí V, Celada P, Artigas F. Troyano-Rodriguez E, et al. Biol Psychiatry. 2014 Dec 15;76(12):937-45. doi: 10.1016/j.biopsych.2014.05.019. Epub 2014 Jun 5. Biol Psychiatry. 2014. PMID: 25038984
BACKGROUND: The neurobiological basis of action of noncompetitive N-methyl-D-aspartate acid receptor (NMDA-R) antagonists is poorly understood. ...However, clozapine reversal of PCP effects is not driven by restoring …
BACKGROUND: The neurobiological basis of action of noncompetitive N-methyl-D-aspartate acid receptor ( …
Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.
Kargieman L, Santana N, Mengod G, Celada P, Artigas F. Kargieman L, et al. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14843-8. doi: 10.1073/pnas.0704848104. Epub 2007 Sep 4. Proc Natl Acad Sci U S A. 2007. PMID: 17785415 Free PMC article.
NMDA receptor (NMDA-R) antagonists are extensively used as schizophrenia models because of their ability to evoke positive and negative symptoms as well as cognitive deficits similar to those of the illness. ...These results shed light on the involveme
NMDA receptor (NMDA-R) antagonists are extensively used as schizophrenia models because of their ability to evok
NMDA antagonist and antipsychotic actions in cortico-subcortical circuits.
Kargieman L, Santana N, Mengod G, Celada P, Artigas F. Kargieman L, et al. Neurotox Res. 2008 Oct;14(2-3):129-40. doi: 10.1007/BF03033805. Neurotox Res. 2008. PMID: 19073421
Schizophrenic patients show a reduced performance in tasks engaging the PFC and a reduction of markers of cellular integrity and function. Non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists are widely used as pharmaco …
Schizophrenic patients show a reduced performance in tasks engaging the PFC and a reduction of markers of cellular integrity and function. N …