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Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor.
Clements JD, Westbrook GL. Clements JD, et al. Neuron. 1991 Oct;7(4):605-13. doi: 10.1016/0896-6273(91)90373-8. Neuron. 1991. PMID: 1681832
The activation kinetics of N-methyl-D-aspartate (NMDA) channels in outside-out patches from cultured hippocampal neurons were analyzed to determine the number of glutamate and glycine binding sites per c …
The activation kinetics of N-methyl-D-aspartate (NMDA) channels in outside-out patches from cultur …
NMDA receptors with locked glutamate-binding clefts open with high efficacy.
Kussius CL, Popescu GK. Kussius CL, et al. J Neurosci. 2010 Sep 15;30(37):12474-9. doi: 10.1523/JNEUROSCI.3337-10.2010. J Neurosci. 2010. PMID: 20844142 Free PMC article.
Based on these results, we suggest that glutamate but not glycine activates NMDA receptors with submaximal efficacy. Low glutamate efficacy may represent a mechanism by which the neurotransmitter maintains control over receptor kinetics d …
Based on these results, we suggest that glutamate but not glycine activates NMDA receptors with submaximal effic …