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Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.
Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y. Okamoto S, et al. Cell Rep. 2018 Jan 16;22(3):706-721. doi: 10.1016/j.celrep.2017.11.102. Cell Rep. 2018. PMID: 29346768 Free article.
However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons
However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD …
Homeostatic versus hedonic control of carbohydrate selection.
Minokoshi Y, Nakajima KI, Okamoto S. Minokoshi Y, et al. J Physiol. 2020 Sep;598(18):3831-3844. doi: 10.1113/JP280066. Epub 2020 Jul 27. J Physiol. 2020. PMID: 32643799 Free article. Review.
Such consumption of an HCD after fasting reverses the fasting-induced increase in the plasma concentration of ketone bodies more rapidly than does refeeding with an HFD alone. 5'-AMP-activated protein kinase (AMPK)-regulated neurons in the parav …
Such consumption of an HCD after fasting reverses the fasting-induced increase in the plasma concentration of ketone bodies more rapi …