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Active cortical dendrites modulate perception.
Takahashi N, Oertner TG, Hegemann P, Larkum ME. Takahashi N, et al. Science. 2016 Dec 23;354(6319):1587-1590. doi: 10.1126/science.aah6066. Science. 2016. PMID: 28008068
There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca(2+) activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) …
There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca(2 …
25th Annual Computational Neuroscience Meeting: CNS-2016.
Sharpee TO, Destexhe A, Kawato M, Sekulić V, Skinner FK, Wójcik DK, Chintaluri C, Cserpán D, Somogyvári Z, Kim JK, Kilpatrick ZP, Bennett MR, Josić K, Elices I, Arroyo D, Levi R, Rodriguez FB, Varona P, Hwang E, Kim B, Han HB, Kim T, McKenna JT, Brown RE, McCarley RW, Choi JH, Rankin J, Popp PO, Rinzel J, Tabas A, Rupp A, Balaguer-Ballester E, Maturana MI, Grayden DB, Cloherty SL, Kameneva T, Ibbotson MR, Meffin H, Koren V, Lochmann T, Dragoi V, Obermayer K, Psarrou M, Schilstra M, Davey N, Torben-Nielsen B, Steuber V, Ju H, Yu J, Hines ML, Chen L, Yu Y, Kim J, Leahy W, Shlizerman E, Birgiolas J, Gerkin RC, Crook SM, Viriyopase A, Memmesheimer RM, Gielen S, Dabaghian Y, DeVito J, Perotti L, Kim AJ, Fenk LM, Cheng C, Maimon G, Zhao C, Widmer Y, Sprecher S, Senn W, Halnes G, Mäki-Marttunen T, Keller D, Pettersen KH, Andreassen OA, Einevoll GT, Yamada Y, Steyn-Ross ML, Alistair Steyn-Ross D, Mejias JF, Murray JD, Kennedy H, Wang XJ, Kruscha A, Grewe J, Benda J, Lindner B, Badel L, Ohta K, Tsuchimoto Y, Kazama H, Kahng B, Tam ND, Pollonini L, Zouridakis G, Soh J, Kim D, Yoo M, Palmer SE, Culmone V, Bojak I, Ferrario A, Merrison-Hort R, Borisyuk R, Kim CS, Tezuka T, Joo P, Rho YA, Burt… See abstract for full author list ➔ Sharpee TO, et al. BMC Neurosci. 2016 Aug 18;17 Suppl 1(Suppl 1):54. doi: 10.1186/s12868-016-0283-6. BMC Neurosci. 2016. PMID: 27534393 Free PMC article.
Torres, Fabiano Baroni, Roberto Latorre, Pablo Varona P40 Different roles for transient and sustained activity during active visual processing Bart Gips, Eric Lowet, Mark J. ...Kleberg, Jochen Triesch P45 Simulation of EMG recording from hand muscle due to TMS of …
Torres, Fabiano Baroni, Roberto Latorre, Pablo Varona P40 Different roles for transient and sustained activity during active v …
Synergistic excitability plasticity in cerebellar functioning.
Ohtsuki G, Shishikura M, Ozaki A. Ohtsuki G, et al. FEBS J. 2020 Nov;287(21):4557-4593. doi: 10.1111/febs.15355. Epub 2020 Jun 11. FEBS J. 2020. PMID: 32367676 Free article. Review.
Systematic examination of excitability plasticity has indicated that the modulation of various types of Ca(2+) - and voltage-dependent K(+) channels underlies the phenomenon, which is also triggered by immune activity. ...In Purkinje cells, modulation of the …
Systematic examination of excitability plasticity has indicated that the modulation of various types of Ca(2+) - and voltage-dependen …
A Top-Down Cortical Circuit for Accurate Sensory Perception.
Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, Murayama M. Manita S, et al. Neuron. 2015 Jun 3;86(5):1304-16. doi: 10.1016/j.neuron.2015.05.006. Epub 2015 May 21. Neuron. 2015. PMID: 26004915 Free article.
A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. ...The circuit consisted of a long-range recipr …
A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to pri …
A multi-scale neurodynamic implementation of incremental grouping.
Domijan D, Marić M. Domijan D, et al. Vision Res. 2022 Aug;197:108057. doi: 10.1016/j.visres.2022.108057. Epub 2022 Apr 26. Vision Res. 2022. PMID: 35487147
In the model, propagation of the enhanced firing rate is achieved by computing the activity difference between two sets of units: attentional or A-units, whose firing rate is modulated by their horizontal collaterals, and non-attentional or N-units that receive only …
In the model, propagation of the enhanced firing rate is achieved by computing the activity difference between two sets of units: att …
NDNF interneurons in layer 1 gain-modulate whole cortical columns according to an animal's behavioral state.
Cohen-Kashi Malina K, Tsivourakis E, Kushinsky D, Apelblat D, Shtiglitz S, Zohar E, Sokoletsky M, Tasaka GI, Mizrahi A, Lampl I, Spiegel I. Cohen-Kashi Malina K, et al. Neuron. 2021 Jul 7;109(13):2150-2164.e5. doi: 10.1016/j.neuron.2021.05.001. Epub 2021 May 25. Neuron. 2021. PMID: 34038743 Free article.
Processing of sensory information in neural circuits is modulated by an animal's behavioral state, but the underlying cellular mechanisms are not well understood. ...Because active NDNF INs are evenly spread in L1 and can affect excitatory neurons across all …
Processing of sensory information in neural circuits is modulated by an animal's behavioral state, but the underlying cellular …
Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis.
Roth BL, Xia Z. Roth BL, et al. Crit Rev Neurobiol. 2004;16(4):229-36. doi: 10.1615/critrevneurobiol.v16.i4.10. Crit Rev Neurobiol. 2004. PMID: 15862107 Review.
The 5-HT2A serotonin receptor represents the principal molecular target for the actions of both classic hallucinogens, which function as agonists, and atypical antipsychotic drugs, which function as inverse agonists. Pharmacological agents that modify the activity of 5-HT2 …
The 5-HT2A serotonin receptor represents the principal molecular target for the actions of both classic hallucinogens, which function as ago …
Matching and selection of a specific subjective experience: conjugate matching and experience.
Vimal RL. Vimal RL. J Integr Neurosci. 2010 Jun;9(2):193-251. doi: 10.1142/s0219635210002214. J Integr Neurosci. 2010. PMID: 20589953 Review.
Furthermore, one could argue that there are at least five sub-pathways in the stimulus-dependent feed-forward pathway and cognitive feedback pathway for information transfer in the brain dynamics: (i) classical axonal-dendritic neural sub-pathway including electromagnetic …
Furthermore, one could argue that there are at least five sub-pathways in the stimulus-dependent feed-forward pathway and cognitive feedback …
Classical-Contextual Interactions in V1 May Rely on Dendritic Computations.
Jin L, Behabadi BF, Jadi MP, Ramachandra CA, Mel BW. Jin L, et al. Neuroscience. 2022 May 1;489:234-250. doi: 10.1016/j.neuroscience.2022.02.033. Epub 2022 Mar 7. Neuroscience. 2022. PMID: 35272004 Free PMC article.
Using a detailed compartmental model, we then show that this boundary-detecting classical-contextual interaction function can be computed by NMDAR-dependent spatial synaptic interactions within PN dendrites - the site where classical and contextual inputs first converge in …
Using a detailed compartmental model, we then show that this boundary-detecting classical-contextual interaction function can be computed by …
Annexin A2 system in human biology: cell surface and beyond.
Luo M, Hajjar KA. Luo M, et al. Semin Thromb Hemost. 2013 Jun;39(4):338-46. doi: 10.1055/s-0033-1334143. Epub 2013 Mar 12. Semin Thromb Hemost. 2013. PMID: 23483454 Free PMC article. Review.
In the peripheral nervous system, p11 directs sodium channels to the plasma membrane, enabling pain perception. In cerebral cortex neurons, A2 stabilizes the microtubule-associated tau protein, which, when mutated, is associated with frontotemporal dementia. …
In the peripheral nervous system, p11 directs sodium channels to the plasma membrane, enabling pain perception. In cerebral …
41 results