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Therapy-related myelodysplastic syndrome.
Candelaria M, Dueñas-Gonzalez A. Candelaria M, et al. Expert Opin Drug Saf. 2015 May;14(5):655-65. doi: 10.1517/14740338.2015.1014340. Epub 2015 Feb 12. Expert Opin Drug Saf. 2015. PMID: 25675961 Review.
INTRODUCTION: Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder characterized by deregulation of apoptosis, dysplastic features in hematopoietic precursors, peripheral blood cytopenias and an increased risk for transformation to acute leukemia …
INTRODUCTION: Myelodysplastic syndrome (MDS) is a heterogeneous clonal disorder characterized by deregulation of apoptosis, dysplasti …
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies.
Davidsson J, Puschmann A, Tedgård U, Bryder D, Nilsson L, Cammenga J. Davidsson J, et al. Leukemia. 2018 May;32(5):1106-1115. doi: 10.1038/s41375-018-0074-4. Epub 2018 Feb 25. Leukemia. 2018. PMID: 29535429 Free PMC article. Review.
Germline mutations in the SAMD9 and SAMD9L genes, located in tandem on chromosome 7, are associated with a clinical spectrum of disorders including the MIRAGE syndrome, ataxia-pancytopenia syndrome and myelodysplasia and leukemia syndrome with monosomy 7 syndrome. Germline …
Germline mutations in the SAMD9 and SAMD9L genes, located in tandem on chromosome 7, are associated with a clinical spectrum of disorders in …
Clonal Hematopoiesis and therapy related MDS/AML.
Desai P, Roboz GJ. Desai P, et al. Best Pract Res Clin Haematol. 2019 Mar;32(1):13-23. doi: 10.1016/j.beha.2019.02.006. Epub 2019 Feb 15. Best Pract Res Clin Haematol. 2019. PMID: 30927970 Review.
Therapy related myeloid neoplasms are malignancies that occur after exposure to chemotherapy/radiation and are associated with poor survival. ...We discuss in this review clinical evidence of association of clonal hematopoiesis with risk of therapy related …
Therapy related myeloid neoplasms are malignancies that occur after exposure to chemotherapy/radiation and are associat …
Can allogeneic hematopoietic cell transplant cure therapy-related acute leukemia?
Madanat YF, Gerds AT. Madanat YF, et al. Best Pract Res Clin Haematol. 2019 Mar;32(1):104-113. doi: 10.1016/j.beha.2019.02.011. Epub 2019 Feb 26. Best Pract Res Clin Haematol. 2019. PMID: 30927969 Review.
Therapy-related myeloid neoplasms (t-MN) include both therapy-related myelodysplastic syndromes as well as therapy-related acute myeloid leukemia. ...Mechanisms for the development of t-MN include direct genotoxic dam …
Therapy-related myeloid neoplasms (t-MN) include both therapy-related myelodysplastic syndromes as well a …
Therapy-related myeloid neoplasms: when genetics and environment collide.
McNerney ME, Godley LA, Le Beau MM. McNerney ME, et al. Nat Rev Cancer. 2017 Aug 24;17(9):513-527. doi: 10.1038/nrc.2017.60. Nat Rev Cancer. 2017. PMID: 28835720 Free PMC article. Review.
Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or radiation administered for a primary condition, typically a malignant disease, solid organ transplant or autoimmune disease. ...
Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or radiation administered for a pri …
Genetic and epigenetic pathways in myelodysplastic syndromes: A brief overview.
Jhanwar SC. Jhanwar SC. Adv Biol Regul. 2015 May;58:28-37. doi: 10.1016/j.jbior.2014.11.002. Epub 2014 Nov 20. Adv Biol Regul. 2015. PMID: 25499150 Review.
Myelodysplastic syndromes (MDS) are a highly heterogenous group of hematopoietic tumors, mainly due to variable clinical features and diverse set of cytogenetic, molecular genetic and epigenetic lesions. ...The risk of developing MDS is relatively higher in some gen …
Myelodysplastic syndromes (MDS) are a highly heterogenous group of hematopoietic tumors, mainly due to variable clinical featu …
Therapy-related myeloid neoplasms: pathobiology and clinical characteristics.
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A. Sill H, et al. Br J Pharmacol. 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. Br J Pharmacol. 2011. PMID: 21039422 Free PMC article. Review.
Therapy-related myeloid neoplasms (t-MNs) are serious long-term consequences of cytotoxic treatments for an antecedent disorder. t-MNs are observed after ionizing radiation as well as conventional chemotherapy including alkylating agents, topoisomerase-II-inh …
Therapy-related myeloid neoplasms (t-MNs) are serious long-term consequences of cytotoxic treatments for an antecedent disorde …
Acute myelogenous leukemia and myelodysplasia secondary to breast cancer treatment: case studies and literature review.
Cole M, Strair R. Cole M, et al. Am J Med Sci. 2010 Jan;339(1):36-40. doi: 10.1097/MAJ.0b013e3181bedb74. Am J Med Sci. 2010. PMID: 19996729 Review.
BACKGROUND AND PURPOSE: Chemotherapy and radiation therapy for breast cancer are known to increase the risk of developing a myelodysplastic syndrome (MDS) and/or acute myelogenous leukemia (AML). ...The purpose of this systemic review is to bring to th …
BACKGROUND AND PURPOSE: Chemotherapy and radiation therapy for breast cancer are known to increase the risk of developing a myelod …
How predictive is the finding of clonal hematopoiesis for the development of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML)?
Steensma DP. Steensma DP. Best Pract Res Clin Haematol. 2021 Dec;34(4):101327. doi: 10.1016/j.beha.2021.101327. Epub 2021 Oct 23. Best Pract Res Clin Haematol. 2021. PMID: 34865699 Review.
Clonal hematopoiesis (CH) - a biological state in which one or a small number of hematopoietic stem or progenitor cells contribute disproportionately to blood cell production, usually as a result of somatic gene mutations in the stem cells - is often considered to be a precursor …
Clonal hematopoiesis (CH) - a biological state in which one or a small number of hematopoietic stem or progenitor cells contribute dispropor …
Treatment-related myelodysplasia and acute leukemia in non-Hodgkin's lymphoma patients.
Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S. Armitage JO, et al. J Clin Oncol. 2003 Mar 1;21(5):897-906. doi: 10.1200/JCO.2003.07.113. J Clin Oncol. 2003. PMID: 12610191 Review.
PURPOSE: Standard therapies for non-Hodgkin's lymphoma (NHL) are associated with an increased risk of developing treatment-related myelodysplastic syndrome or acute myelogenous leukemia (tMDS/AML). ...Unless noted, data are reported only for NHL …
PURPOSE: Standard therapies for non-Hodgkin's lymphoma (NHL) are associated with an increased risk of developing treatment-related …
41 results