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Page 1
MCT4 blockade increases the efficacy of immune checkpoint blockade.
Babl N, Decking SM, Voll F, Althammer M, Sala-Hojman A, Ferretti R, Korf C, Schmidl C, Schmidleithner L, Nerb B, Matos C, Koehl GE, Siska P, Bruss C, Kellermeier F, Dettmer K, Oefner PJ, Wichland M, Ugele I, Bohr C, Herr W, Ramaswamy S, Heinrich T, Herhaus C, Kreutz M, Renner K. Babl N, et al. Among authors: sala hojman a. J Immunother Cancer. 2023 Oct;11(10):e007349. doi: 10.1136/jitc-2023-007349. J Immunother Cancer. 2023. PMID: 37880183 Free PMC article.
Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy.
Rajendra E, Lademann CA, Mason B, Mardin BR, Armstrong L, Peripolli S, Kreis J, Konstantinou T, Pehl U, Bomke J, Scharrelmann S, Perera D, Leuthner B, Pinto MF, Davis OA, Galbiati A, Toste Rêgo A, McWhirter CL, Elinati E, Sala-Hojman A, Lefranc J, Mann SE, Heald RA, Zenke FT, Smith GCM, Robinson HMR, Burgdorf LT. Rajendra E, et al. Among authors: sala hojman a. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1279. doi: 10.1093/nar/gkaf1279. Nucleic Acids Res. 2025. PMID: 41359388 Free PMC article.
Lactic acid promotes an MDSC-like phenotype via HIF1α stabilization with impact on prognosis in renal cell carcinoma.
Babl N, Voll F, Martowicz A, Bruss C, Maddaloni M, Schmidl C, Rehli M, Loipfinger S, Strieder N, Gebhard C, Hoffmann P, Singh SM, Sala-Hojman A, Ferretti R, Matos C, Simon M, Brummer C, Schnell A, Hofbauer J, Decking SM, Hau P, Vollmann-Zwerenz A, Dettmer K, Oefner PJ, Althammer M, Laufs J, Friedl S, Heinrich T, Herhaus C, Evert K, Mayr R, Afonso J, Baltazar F, Herr W, Siska PJ, Renner K, Kreutz M. Babl N, et al. Among authors: sala hojman a. Cancer Lett. 2026 Feb 28;639:218209. doi: 10.1016/j.canlet.2025.218209. Epub 2025 Dec 8. Cancer Lett. 2026. PMID: 41371433 Free article.
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.
Mann SE, Lefranc J, Alkhatib O, Boivin R, Bomke J, Byrne RT, Cassona CP, Chen X, Cornaciu I, Costales P, Davis OA, DeSelm L, Elinati E, Follows B, Galbiati A, Göldner C, Hayre JK, Jorand-Lebrun C, Lademann CA, Leuthner B, Majithiya JB, Malta CF, Mason B, McWhirter CL, Neff B, Nissink JWM, Pehl U, Petersson C, Pica A, Pinto MF, Rajendra E, Rakers C, Toste Rêgo A, Robinson HMR, Sala-Hojman A, Schaedler TA, Schürmann PJL, Silva DO, Smith GCM, Sorrell F, Webster GR, Zenke FT, Heald RA, Burgdorf LT. Mann SE, et al. Among authors: sala hojman a. J Med Chem. 2025 Oct 9;68(19):20410-20434. doi: 10.1021/acs.jmedchem.5c01526. Epub 2025 Sep 17. J Med Chem. 2025. PMID: 40963090
Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.
Buchstaller HP, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, Dong L, Fuchß T, Germann M, Knehans T, Krier M, Lecomte M, Müller D, Müller SR, Leuthner B, Lindemann R, Musil D, Nowak M, Reither V, Rettig C, Schindler CEM, Pakulska U, Spuck D, Wegener A, Zarębski A. Buchstaller HP, et al. Among authors: sala hojman a. J Med Chem. 2023 Jul 13;66(13):8666-8686. doi: 10.1021/acs.jmedchem.3c00332. Epub 2023 Jul 5. J Med Chem. 2023. PMID: 37403966
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.
Pascual-García M, Bonfill-Teixidor E, Planas-Rigol E, Rubio-Perez C, Iurlaro R, Arias A, Cuartas I, Sala-Hojman A, Escudero L, Martínez-Ricarte F, Huber-Ruano I, Nuciforo P, Pedrosa L, Marques C, Braña I, Garralda E, Vieito M, Squatrito M, Pineda E, Graus F, Espejo C, Sahuquillo J, Tabernero J, Seoane J. Pascual-García M, et al. Among authors: sala hojman a. Nat Commun. 2019 Jun 11;10(1):2416. doi: 10.1038/s41467-019-10369-9. Nat Commun. 2019. PMID: 31186412 Free PMC article.
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, Ramaswamy S, Bartosik A, Czauderna F, Crowley L, Wahra P, Schilke H, Böpple P, Dudek Ł, Leś M, Niedziejko P, Olech K, Pawlik H, Włoszczak Ł, Zuchowicz K, Suarez Alvarez JR, Martyka J, Sitek E, Mikulski M, Szczęśniak J, Jäckel S, Krier M, Król M, Wegener A, Gałęzowski M, Nowak M, Becker F, Herhaus C. Heinrich T, et al. Among authors: sala hojman a. J Med Chem. 2021 Aug 26;64(16):11904-11933. doi: 10.1021/acs.jmedchem.1c00448. Epub 2021 Aug 12. J Med Chem. 2021. PMID: 34382802