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Adeno-associated virus vector transduction of vascular smooth muscle cells in vivo.
Richter M, Iwata A, Nyhuis J, Nitta Y, Miller AD, Halbert CL, Allen MD. Richter M, et al. Physiol Genomics. 2000 Apr 27;2(3):117-27. doi: 10.1152/physiolgenomics.2000.2.3.117. Physiol Genomics. 2000. PMID: 11015590
We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid artery model. ...Medial vascular smooth muscle cells were the main cell type transduced even with an int …
We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid …
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Chen S, Kapturczak M, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Campbell-Thompson M, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Chen S, et al. Hum Gene Ther. 2005 Feb;16(2):235-47. doi: 10.1089/hum.2005.16.235. Hum Gene Ther. 2005. PMID: 15761263 Free PMC article.
Recombinant adeno-associated virus (rAAV) has become an attractive tool for gene therapy because of its ability to transduce both dividing and nondividing cells, elicit a limited immune response, and the capacity for imparting long-term transgene expre …
Recombinant adeno-associated virus (rAAV) has become an attractive tool for gene therapy because of its ability to tran …
Adeno-associated virus mediated gene delivery into coronary microvessels of chronically instrumented dogs.
Post H, Kajstura J, Lei B, Sessa WC, Byrne B, Anversa P, Hintze TH, Recchia FA. Post H, et al. J Appl Physiol (1985). 2003 Oct;95(4):1688-94. doi: 10.1152/japplphysiol.00896.2002. Epub 2003 Jul 3. J Appl Physiol (1985). 2003. PMID: 12844500 Free article.
The objective of this study was to assess the potential of adeno-associated virus (AAV)-mediated gene delivery into coronary microvessels in vivo in a large animal. ...In LV tissue slices, a fluorescein-labeled antibody to GFP stained endothelial and …
The objective of this study was to assess the potential of adeno-associated virus (AAV)-mediated gene delivery into cor …
Successful transfection of genes using AAV-2/9 vector in swine coronary and peripheral arteries.
Pankajakshan D, Makinde TO, Gaurav R, Del Core M, Hatzoudis G, Pipinos I, Agrawal DK. Pankajakshan D, et al. J Surg Res. 2012 Jun 1;175(1):169-75. doi: 10.1016/j.jss.2011.02.032. Epub 2011 Mar 21. J Surg Res. 2012. PMID: 21529824 Free PMC article.
BACKGROUND: Gene therapy has attracted attention for its potential to treat several cardiovascular diseases. The use of adeno-associated viral (AAV) vectors to facilitate therapeutic gene transfer to suppress intimal hyperplasia is a promising concept. The ob …
BACKGROUND: Gene therapy has attracted attention for its potential to treat several cardiovascular diseases. The use of adeno-asso …
Adeno-associated virus-mediated gene transfer into rat carotid arteries.
Rolling F, Nong Z, Pisvin S, Collen D. Rolling F, et al. Gene Ther. 1997 Aug;4(8):757-61. doi: 10.1038/sj.gt.3300465. Gene Ther. 1997. PMID: 9338002
The feasibility of adeno-associated virus (AAV)-mediated gene transfer into isolated segments of normal and balloon-injured rat carotid arteries was studied using a recombinant AAV carrying CMVlacZ as a reporter gene. ...Microscopic examination demonstrated c …
The feasibility of adeno-associated virus (AAV)-mediated gene transfer into isolated segments of normal and balloon-inj …
Adeno-associated virus vectors for vascular gene delivery.
Lynch CM, Hara PS, Leonard JC, Williams JK, Dean RH, Geary RL. Lynch CM, et al. Circ Res. 1997 Apr;80(4):497-505. Circ Res. 1997. PMID: 9118480
A variety of delivery systems have been used to genetically modify vascular endothelial cells and smooth muscle cells (SMCs), but currently available systems suffer from either inefficient in vivo gene transfer, transient episomal vect …
A variety of delivery systems have been used to genetically modify vascular endothelial cells and smooth muscle …
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.
Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K. Ito T, et al. Circ Res. 2007 Sep 28;101(7):734-41. doi: 10.1161/CIRCRESAHA.107.153023. Epub 2007 Aug 2. Circ Res. 2007. PMID: 17673672
Three-week-old Wistar rats were intramuscularly injected with an adeno-associated virus serotype 1 vector expressing IL-10, followed by monocrotaline injection at 7 weeks old. ...In vitro analysis revealed that IL-10 significantly inhibited excessive p …
Three-week-old Wistar rats were intramuscularly injected with an adeno-associated virus serotype 1 vector expres …
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.
Gruchała M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholová I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Büeler H, Ylä-Herttuala S. Gruchała M, et al. J Gene Med. 2004 May;6(5):545-54. doi: 10.1002/jgm.535. J Gene Med. 2004. PMID: 15133765
RESULTS: In normal arteries AAV transduced mainly medial smooth muscle cells (SMC) while Adv transduced exclusively endothelial cells (EC). ...AAV caused only a modest increase in EC VCAM-1 expression and proliferation rate of vascular cells …
RESULTS: In normal arteries AAV transduced mainly medial smooth muscle cells (SMC) while Adv transduced exclusively end …
A CMV-actin-globin hybrid promoter improves adeno-associated viral vector gene expression in the arterial wall in vivo.
Nitta Y, Kawamoto S, Halbert C, Iwata A, Miller AD, Miyazaki J, Allen MD. Nitta Y, et al. J Gene Med. 2005 Oct;7(10):1348-55. doi: 10.1002/jgm.784. J Gene Med. 2005. PMID: 15945122
BACKGROUND: Adeno-associated virus (AAV) vectors are attractive tools for direct intralumenal arterial gene transfer in interventional cardiology or cardiovascular surgery, but clinical application has been constrained by poor gene expression in this s …
BACKGROUND: Adeno-associated virus (AAV) vectors are attractive tools for direct intralumenal arterial gene tran …
Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5.
Sen S, Conroy S, Hynes SO, McMahon J, O'Doherty A, Bartlett JS, Akhtar Y, Adegbola T, Connolly CE, Sultan S, Barry F, Katusic ZS, O'Brien T. Sen S, et al. J Gene Med. 2008 Feb;10(2):143-51. doi: 10.1002/jgm.1133. J Gene Med. 2008. PMID: 18067196
Recombinant adeno-associated virus (AAV) is a promising viral vector but its use in the vasculature has produced conflicting results and serotypes other than AAV2 have not been intensively studied. We investigated the efficiency of alternative AAV sero …
Recombinant adeno-associated virus (AAV) is a promising viral vector but its use in the vasculature has produced …