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Page 1
Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
Zhou L, Bai X, Huang J, Tan Y, Yang Q. Zhou L, et al. Nutr Hosp. 2023 Aug 28;40(4):724-731. doi: 10.20960/nh.04394. Nutr Hosp. 2023. PMID: 37334792 Free article. Clinical Trial. English.
Meanwhile, 115 participants with cognitive impairment were randomly assigned in equal proportions to two groups: vitamin B12 treatment group (n = 58, vitamin B12 500 mg/d intramuscularly for seven days, followed by cobamamide 0.25 mg/d and methylcobalamin 0.50 mg/d) and th …
Meanwhile, 115 participants with cognitive impairment were randomly assigned in equal proportions to two groups: vitamin B12 treatment group …
An Adenosylcobalamin Specific Whole-Cell Biosensor.
Quispe Haro JJ, Wegner SV. Quispe Haro JJ, et al. Adv Healthc Mater. 2023 Oct;12(25):e2300835. doi: 10.1002/adhm.202300835. Epub 2023 May 1. Adv Healthc Mater. 2023. PMID: 37070155 Free PMC article.
Here, a whole-cell agglutination assay that is specific for adenosylcobalamin (AboB12), which is one of two bioactive forms, is reported. This biosensor consists of Escherichia coli that express the AdoB12 specific binding domain of CarH at their surface. ...
Here, a whole-cell agglutination assay that is specific for adenosylcobalamin (AboB12), which is one of two bioactive forms, is repor …
Targeting leucine-rich repeat serine/threonine-protein kinase 2 sensitizes pancreatic ductal adenocarcinoma to anti-PD-L1 immunotherapy.
Sun K, Zhang X, Lao M, He L, Wang S, Yang H, Xu J, Tang J, Hong Z, Song J, Guo C, Li M, Liu X, Chen Y, Zhang H, Zhou J, Lin J, Zhang S, Hong Y, Huang J, Liang T, Bai X. Sun K, et al. Mol Ther. 2023 Oct 4;31(10):2929-2947. doi: 10.1016/j.ymthe.2023.07.021. Epub 2023 Jul 28. Mol Ther. 2023. PMID: 37515321 Free PMC article.
LRRK2 inhibition attenuated PD-1/PD-L1 blockade-mediated, T cell-induced upregulation of LRRK2/PD-L1, thus sensitizing the mice to anti-PD-L1 therapy. In addition, adenosylcobalamin, the activated form of vitamin B12, which was found to be a broad-spectrum inhibitor of LRR …
LRRK2 inhibition attenuated PD-1/PD-L1 blockade-mediated, T cell-induced upregulation of LRRK2/PD-L1, thus sensitizing the mice to anti-PD-L …
Biomarkers to predict disease progression and therapeutic response in isolated methylmalonic acidemia.
Manoli I, Gebremariam A, McCoy S, Pass AR, Gagné J, Hall C, Ferry S, Van Ryzin C, Sloan JL, Sacchetti E, Catesini G, Rizzo C, Martinelli D, Spada M, Dionisi-Vici C, Venditti CP. Manoli I, et al. J Inherit Metab Dis. 2023 Jul;46(4):554-572. doi: 10.1002/jimd.12636. Epub 2023 Jun 6. J Inherit Metab Dis. 2023. PMID: 37243446 Free PMC article. Review.
Methylmalonic Acidemia (MMA) is a heterogenous group of inborn errors of metabolism caused by a defect in the methylmalonyl-CoA mutase (MMUT) enzyme or the synthesis and transport of its cofactor, 5'-deoxy-adenosylcobalamin. It is characterized by life-threatening episodes …
Methylmalonic Acidemia (MMA) is a heterogenous group of inborn errors of metabolism caused by a defect in the methylmalonyl-CoA mutase (MMUT …
Visualizing RNA conformational and architectural heterogeneity in solution.
Ding J, Lee YT, Bhandari Y, Schwieters CD, Fan L, Yu P, Tarosov SG, Stagno JR, Ma B, Nussinov R, Rein A, Zhang J, Wang YX. Ding J, et al. Nat Commun. 2023 Feb 9;14(1):714. doi: 10.1038/s41467-023-36184-x. Nat Commun. 2023. PMID: 36759615 Free PMC article.
Through direct visualization using atomic force microscopy (AFM) and the adenosylcobalamin riboswitch aptamer domain as an example, we show that a single RNA sequence folds into conformationally and architecturally heterogeneous structures under near-physiological solution …
Through direct visualization using atomic force microscopy (AFM) and the adenosylcobalamin riboswitch aptamer domain as an example, w …
The 2-methylpropene degradation pathway in Mycobacteriaceae family strains.
Helbich S, Barrantes I, Dos Anjos Borges LG, Pieper DH, Vainshtein Y, Sohn K, Engesser KH. Helbich S, et al. Environ Microbiol. 2023 Nov;25(11):2163-2181. doi: 10.1111/1462-2920.16449. Epub 2023 Jun 15. Environ Microbiol. 2023. PMID: 37321960
In both strains, involved genes are arranged in clusters of 61.0 and 58.5 kbp, respectively, which also contain the genes coding for parts of the aerobic pathway of adenosylcobalamin synthesis. This vitamin is essential for the carbon rearrangement reaction catalysed by th …
In both strains, involved genes are arranged in clusters of 61.0 and 58.5 kbp, respectively, which also contain the genes coding for parts o …
Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase.
Vaccaro FA, Faber DA, Andree GA, Born DA, Kang G, Fonseca DR, Jost M, Drennan CL. Vaccaro FA, et al. J Biol Chem. 2023 Sep;299(9):105109. doi: 10.1016/j.jbc.2023.105109. Epub 2023 Jul 28. J Biol Chem. 2023. PMID: 37517695 Free PMC article.
The G-protein chaperone MMAA in humans (MeaB in bacteria) uses GTP hydrolysis to facilitate the delivery of adenosylcobalamin (AdoCbl) to AdoCbl-dependent methylmalonyl-CoA mutase, an essential metabolic enzyme. ...
The G-protein chaperone MMAA in humans (MeaB in bacteria) uses GTP hydrolysis to facilitate the delivery of adenosylcobalamin (AdoCbl …
Development of vitamin B12 dependency in Saccharomyces cerevisiae.
Lehner S, Boles E. Lehner S, et al. FEMS Yeast Res. 2023 Jan 4;23:foad020. doi: 10.1093/femsyr/foad020. FEMS Yeast Res. 2023. PMID: 36941127
Growth of MetH-containing yeast cells on methionine-free media is only possible with the addition of adenosylcobalamin or methylcobalamin. A heterologous vitamin B12 transport system turned out to be not necessary for the uptake of cobalamins. ...
Growth of MetH-containing yeast cells on methionine-free media is only possible with the addition of adenosylcobalamin or methylcobal …
A synthetic cell-free 36-enzyme reaction system for vitamin B12 production.
Kang Q, Fang H, Xiang M, Xiao K, Jiang P, You C, Lee SY, Zhang D. Kang Q, et al. Nat Commun. 2023 Aug 24;14(1):5177. doi: 10.1038/s41467-023-40932-4. Nat Commun. 2023. PMID: 37620358 Free PMC article.
Adenosylcobalamin (AdoCbl), a biologically active form of vitamin B(12) (coenzyme B(12)), is one of the most complex metal-containing natural compounds and an essential vitamin for animals. ...
Adenosylcobalamin (AdoCbl), a biologically active form of vitamin B(12) (coenzyme B(12)), is one of the most complex metal-containing …
25 results