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Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Knott GJ, et al. Among authors: adler ba. Elife. 2019 Aug 9;8:e49110. doi: 10.7554/eLife.49110. Elife. 2019. PMID: 31397669 Free PMC article.
High-throughput mapping of the phage resistance landscape in E. coli.
Mutalik VK, Adler BA, Rishi HS, Piya D, Zhong C, Koskella B, Kutter EM, Calendar R, Novichkov PS, Price MN, Deutschbauer AM, Arkin AP. Mutalik VK, et al. Among authors: adler ba. PLoS Biol. 2020 Oct 13;18(10):e3000877. doi: 10.1371/journal.pbio.3000877. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33048924 Free PMC article.
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing.
Adler BA, Hessler T, Cress BF, Lahiri A, Mutalik VK, Barrangou R, Banfield J, Doudna JA. Adler BA, et al. Nat Microbiol. 2022 Dec;7(12):1967-1979. doi: 10.1038/s41564-022-01258-x. Epub 2022 Oct 31. Nat Microbiol. 2022. PMID: 36316451 Free PMC article.
Improved genome editing by an engineered CRISPR-Cas12a.
Ma E, Chen K, Shi H, Stahl EC, Adler B, Trinidad M, Liu J, Zhou K, Ye J, Doudna JA. Ma E, et al. Nucleic Acids Res. 2022 Dec 9;50(22):12689-12701. doi: 10.1093/nar/gkac1192. Nucleic Acids Res. 2022. PMID: 36537251 Free PMC article.
To TnpB or not TnpB? Cas12 is the answer.
Yoon PH, Adler BA, Doudna JA. Yoon PH, et al. Among authors: adler ba. Nat Chem Biol. 2023 Mar;19(3):263-264. doi: 10.1038/s41589-022-01243-9. Epub 2023 Feb 16. Nat Chem Biol. 2023. PMID: 36797405 No abstract available.
Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection.
Armbruster EG, Lee J, Hutchings J, VanderWal AR, Enustun E, Adler BA, Aindow A, Deep A, Rodriguez ZK, Morgan CJ, Ghassemian M, Charles E, Cress BF, Savage DF, Doudna JA, Pogliano K, Corbett KD, Villa E, Pogliano J. Armbruster EG, et al. Among authors: adler ba. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.558163. doi: 10.1101/2023.09.20.558163. bioRxiv. 2023. PMID: 37781618 Free PMC article. Preprint.
29 results