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Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Sundaram A, et al. Among authors: adler m. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127578. doi: 10.1016/j.bmcl.2020.127578. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007395 Free PMC article.
Triazolopyridazine LRRK2 kinase inhibitors.
Franzini M, Ye XM, Adler M, Aubele DL, Garofalo AW, Gauby S, Goldbach E, Probst GD, Quinn KP, Santiago P, Sham HL, Tam D, Truong A, Ren Z. Franzini M, et al. Among authors: adler m. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1967-73. doi: 10.1016/j.bmcl.2013.02.043. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23454015
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Ng RA, Sun M, Bowers S, Hom RK, Probst GD, John V, Fang LY, Maillard M, Gailunas A, Brogley L, Neitz RJ, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Adler M, Yao N, Zmolek W, Nakamura D, Quinn KP, Sauer JM, Bova MP, Ruslim L, Artis DR, Yednock TA. Ng RA, et al. Among authors: adler m. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4674-9. doi: 10.1016/j.bmcl.2013.06.006. Epub 2013 Jun 11. Bioorg Med Chem Lett. 2013. PMID: 23856050
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Garofalo AW, Adler M, Aubele DL, Brigham EF, Chian D, Franzini M, Goldbach E, Kwong GT, Motter R, Probst GD, Quinn KP, Ruslim L, Sham HL, Tam D, Tanaka P, Truong AP, Ye XM, Ren Z. Garofalo AW, et al. Among authors: adler m. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1974-7. doi: 10.1016/j.bmcl.2013.02.041. Epub 2013 Feb 15. Bioorg Med Chem Lett. 2013. PMID: 23453068
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C, Sukovich D, Whitlow M, Chen D, Buckman BO. Islam I, et al. Among authors: adler m. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi: 10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. Bioorg Med Chem Lett. 2018. PMID: 30201291
Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Garofalo AW, Adler M, Aubele DL, Bowers S, Franzini M, Goldbach E, Lorentzen C, Neitz RJ, Probst GD, Quinn KP, Santiago P, Sham HL, Tam D, Truong AP, Ye XM, Ren Z. Garofalo AW, et al. Among authors: adler m. Bioorg Med Chem Lett. 2013 Jan 1;23(1):71-4. doi: 10.1016/j.bmcl.2012.11.021. Epub 2012 Nov 16. Bioorg Med Chem Lett. 2013. PMID: 23219325
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Kochanny MJ, Adler M, Ewing J, Griedel BD, Ho E, Karanjawala R, Lee W, Lentz D, Liang AM, Morrissey MM, Phillips GB, Post J, Sacchi KL, Sakata ST, Subramanyam B, Vergona R, Walters J, White KA, Whitlow M, Ye B, Zhao Z, Shaw KJ. Kochanny MJ, et al. Among authors: adler m. Bioorg Med Chem. 2007 Mar 1;15(5):2127-46. doi: 10.1016/j.bmc.2006.12.019. Epub 2006 Dec 13. Bioorg Med Chem. 2007. PMID: 17227710
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Kirkland TA, Adler M, Bauman JG, Chen M, Haeggström JZ, King B, Kochanny MJ, Liang AM, Mendoza L, Phillips GB, Thunnissen M, Trinh L, Whitlow M, Ye B, Ye H, Parkinson J, Guilford WJ. Kirkland TA, et al. Among authors: adler m. Bioorg Med Chem. 2008 May 1;16(9):4963-83. doi: 10.1016/j.bmc.2008.03.042. Epub 2008 Mar 20. Bioorg Med Chem. 2008. PMID: 18394906
1,236 results