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43 results

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Page 1
Adrafinil-induced orofacial dyskinesia.
Thobois S, Xie J, Mollion H, Benatru I, Broussolle E. Thobois S, et al. Mov Disord. 2004 Aug;19(8):965-6. doi: 10.1002/mds.20154. Mov Disord. 2004. PMID: 15300665
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. They were se …
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacologi …
Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case.
Ameline A, Gheddar L, Raul JS, Kintz P. Ameline A, et al. Forensic Sci Res. 2020 Jan 29;5(4):322-326. doi: 10.1080/20961790.2019.1704482. Forensic Sci Res. 2020. PMID: 33457050 Free PMC article.
The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in possession of vials of adrafinil and suspected of trafficking. ...According to these re …
The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in …
Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs.
Siwak CT, Tapp PD, Milgram NW. Siwak CT, et al. Pharmacol Biochem Behav. 2003 Aug;76(1):161-8. doi: 10.1016/s0091-3057(03)00211-9. Pharmacol Biochem Behav. 2003. PMID: 13679229
We wanted to further explore the cognitive effects of adrafinil in dogs. The purpose of the present study was to determine the effect of oral administration of adrafinil on visuospatial function in dogs. Eighteen aged beagle dogs were tested on a delayed nonmatching …
We wanted to further explore the cognitive effects of adrafinil in dogs. The purpose of the present study was to determine the effect …
Adrafinil: effects on behavior and cognition in aged canines.
Siwak CT, Callahan H, Milgram NW. Siwak CT, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):709-26. doi: 10.1016/s0278-5846(00)00103-2. Prog Neuropsychopharmacol Biol Psychiatry. 2000. PMID: 11191710
Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil causes a long-lasting increase in high frequency electroencephalographic activity recorded from cortical electrodes. 6. These results in …
Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil …
[Noradrenaline and cerebral aging].
Jouvet M, Albarede JL, Lubin S, Meyrignac C. Jouvet M, et al. Encephale. 1991 May-Jun;17(3):187-95. Encephale. 1991. PMID: 1864252 Review. French.
The recent development of medications improving alertness (adrafinil, modafinil) with a pure central action and specifically noradrenergic, may contribute to an improvement in these multifactorial disorders....
The recent development of medications improving alertness (adrafinil, modafinil) with a pure central action and specifically noradren …
Behavioral activating effects of adrafinil in aged canines.
Siwak CT, Gruet P, Woehrlé F, Schneider M, Muggenburg BA, Murphey HL, Callahan H, Milgram NW. Siwak CT, et al. Pharmacol Biochem Behav. 2000 Jun;66(2):293-300. doi: 10.1016/s0091-3057(00)00188-x. Pharmacol Biochem Behav. 2000. PMID: 10880681
Adrafinil also caused a transient increase in directed sniffing. At the highest dose level, adrafinil caused a decrease in urination frequency. ...The individual differences were correlated with changes in serum levels of adrafinil 10 h following treatment... …
Adrafinil also caused a transient increase in directed sniffing. At the highest dose level, adrafinil caused a decrease in uri …
[Spironolactone-induced pemphigoid].
Grange F, Scrivener Y, Koessler A, Straub P, Guillaume JC. Grange F, et al. Ann Dermatol Venereol. 1997;124(10):700-2. Ann Dermatol Venereol. 1997. PMID: 9740867 French.
The patient had been taking alimemazine, adrafinil, flunarizine, spironolactone and furosemide as long-term treatment. Spironolactone alone was withdrawn. ...
The patient had been taking alimemazine, adrafinil, flunarizine, spironolactone and furosemide as long-term treatment. Spironolactone …
Doping control analysis for adrafinil and its major metabolites in human urine.
Lu J, Wang X, Yang S, Liu X, Qin Y, Shen L, Wu Y, Xu Y, Wu M, Ouyang G. Lu J, et al. Rapid Commun Mass Spectrom. 2009 Jun;23(11):1592-600. doi: 10.1002/rcm.4044. Rapid Commun Mass Spectrom. 2009. PMID: 19399790
A new and reliable two-step liquid chromatography/tandem mass spectrometry (LC/MS/MS) method in combination with gas chromatography/mass spectrometry (GC/MS) for the screening and confirmation of adrafinil and its major metabolites, modafinil and modafinil acid, in human u …
A new and reliable two-step liquid chromatography/tandem mass spectrometry (LC/MS/MS) method in combination with gas chromatography/mass spe …
LC-ESI-MS determination and pharmacokinetics of adrafinil in rats.
Rao RN, Shinde DD, Talluri MV, Agawane SB. Rao RN, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):119-23. doi: 10.1016/j.jchromb.2008.07.025. Epub 2008 Jul 29. J Chromatogr B Analyt Technol Biomed Life Sci. 2008. PMID: 18723408
The assay was specific, accurate (R.S.D.<2.6%), precise and reproducible (within- and between-day precisions R.S.D. <7.0% and <9.0%, respectively). Adrafinil in rat serum was stable over three freeze-thaw cycles at ambient temperature for 6 h. The method had a low …
The assay was specific, accurate (R.S.D.<2.6%), precise and reproducible (within- and between-day precisions R.S.D. <7.0% and <9.0% …
Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs.
Siwak CT, Gruet P, Woehrlé F, Muggenburg BA, Murphey HL, Milgram NW. Siwak CT, et al. Am J Vet Res. 2000 Nov;61(11):1410-4. doi: 10.2460/ajvr.2000.61.1410. Am J Vet Res. 2000. PMID: 11108188 Free article. Clinical Trial.
OBJECTIVE: To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. ANIMALS: 36 Beagles between 9 and 16 years old. ...CONCLUSIONS AND CLINICAL RELEVANCE: Treatment with adrafinil may improve the quality of life of …
OBJECTIVE: To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. ANIMALS: 36 Be …
43 results