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Adverse outcome pathways: From research to regulation scientific workshop report.
Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. Kleinstreuer NC, et al. Regul Toxicol Pharmacol. 2016 Apr;76:39-50. doi: 10.1016/j.yrtph.2016.01.007. Epub 2016 Jan 14. Regul Toxicol Pharmacol. 2016. PMID: 26774756 Free PMC article.
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductiv …
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular in …
Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.
Shatkin JA, Ong KJ, Beaudrie C, Clippinger AJ, Hendren CO, Haber LT, Hill M, Holden P, Kennedy AJ, Kim B, MacDonell M, Powers CM, Sharma M, Sheremeta L, Stone V, Sultan Y, Turley A, White RH. Shatkin JA, et al. Risk Anal. 2016 Aug;36(8):1520-37. doi: 10.1111/risa.12683. Epub 2016 Aug 11. Risk Anal. 2016. PMID: 27510619 Review.
Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coor …
Participants recognized that leadership is required from within the scientific community to address basic challenges, including stand …
Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework.
Chauhan V, Wilkins RC, Beaton D, Sachana M, Delrue N, Yauk C, O'Brien J, Marchetti F, Halappanavar S, Boyd M, Villeneuve D, Barton-Maclaren TS, Meek B, Anghel C, Heghes C, Barber C, Perkins E, Leblanc J, Burtt J, Laakso H, Laurier D, Lazo T, Whelan M, Thomas R, Cool D. Chauhan V, et al. Int J Radiat Biol. 2021;97(4):431-441. doi: 10.1080/09553002.2021.1884314. Epub 2021 Mar 1. Int J Radiat Biol. 2021. PMID: 33539251 Free PMC article.
To this end, a virtual workshop was held on 7 and 8 October 2020 with experts from the OECD AOP Programme together with the radiation and chemical research/regulation communities. The workshop was a coordinated effort of Health Canada, the Electric Pow …
To this end, a virtual workshop was held on 7 and 8 October 2020 with experts from the OECD AOP Programme together with the radiation …
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework.
Qin SJ, Zeng QG, Zeng HX, Li SP, Andersson J, Zhao B, Oudin A, Kanninen KM, Jalava P, Jin NX, Yang M, Lin LZ, Liu RQ, Dong GH, Zeng XW. Qin SJ, et al. Sci Total Environ. 2024 Oct 15;947:174450. doi: 10.1016/j.scitotenv.2024.174450. Epub 2024 Jul 3. Sci Total Environ. 2024. PMID: 38969138 Review.
However, the underlying mechanism has not yet been fully illustrated due to the variety of the study models, different endpoints, etc. The adverse outcome pathway (AOP) framework is a pathway-based approach that could systematize mechanistic knowledge to assist heal …
However, the underlying mechanism has not yet been fully illustrated due to the variety of the study models, different endpoints, etc. The …
Effects of a 12-week Baduanjin regimen on biomechanical properties of axial muscle fascia in ankylosing spondylitis.
Xie Y, Zhang Q, Xin D, Wang Y. Xie Y, et al. Medicine (Baltimore). 2024 Dec 27;103(52):e40522. doi: 10.1097/MD.0000000000040522. Medicine (Baltimore). 2024. PMID: 39969360 Free PMC article. Clinical Trial.
No significant changes were observed in the nonintervention group. The Baduanjin group reported only mild muscle pain initially, which resolved with appropriate management, with no serious adverse effects noted. ...By improving these properties, Baduanjin may reduce …
No significant changes were observed in the nonintervention group. The Baduanjin group reported only mild muscle pain initially, whic …
Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.
Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. Clippinger AJ, et al. Toxicol In Vitro. 2018 Apr;48:53-70. doi: 10.1016/j.tiv.2017.12.011. Epub 2017 Dec 22. Toxicol In Vitro. 2018. PMID: 29277654 Free PMC article.
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulatory Data Requirements", explored current testing requirements and ongoing efforts to achieve global regulatory acceptance for non-animal tes …
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulat …
Accelerating Drug Translation: Role of Coronary Computed Tomography Angiography Plaque Imaging Candidates as Surrogate Biomarkers.
Baskaran L, Dutta U, Xiaomeng W, Gray MP, Chan M, Branch K, Budoff M, Blankstein R, Douglas PS, Figtree GA. Baskaran L, et al. JACC Cardiovasc Imaging. 2025 Aug;18(8):912-927. doi: 10.1016/j.jcmg.2025.03.017. JACC Cardiovasc Imaging. 2025. PMID: 40769623 Free article. Review.
There is an unmet need for new pathways to evaluate therapeutic targets and drugs for coronary artery disease (CAD). The use of major adverse cardiovascular events as a primary outcome is advantageous for rigor, but challenges related to large sample size req …
There is an unmet need for new pathways to evaluate therapeutic targets and drugs for coronary artery disease (CAD). The use of major …
Ascertaining sensitive exposure biomarkers of various metal(loid)s to embryo implantation.
Ren M, Wu T, Yang S, Gao N, Lan C, Zhang H, Lin W, Su S, Yan L, Zhuang L, Lu Q, Xu J, Han B, Bai Z, Meng F, Chen Y, Pan B, Wang B, Lu X, Fang M. Ren M, et al. Environ Pollut. 2024 Apr 15;347:123679. doi: 10.1016/j.envpol.2024.123679. Epub 2024 Mar 8. Environ Pollut. 2024. PMID: 38462199
An analytical framework was established by integrating epidemiological association results, comprehensive literature searching, and knowledge-based adverse outcome pathway (AOP) networks. The sensitive biomarkers of metal(loid)s along with potential biological pa …
An analytical framework was established by integrating epidemiological association results, comprehensive literature searching, and knowledg …
Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Lynch AM, Eastmond D, Elhajouji A, Froetschl R, Kirsch-Volders M, Marchetti F, Masumura K, Pacchierotti F, Schuler M, Tweats D. Lynch AM, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Nov;847:403025. doi: 10.1016/j.mrgentox.2019.02.006. Epub 2019 Mar 2. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31699346 Review.
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a review of the scientific literature on the biological mechanisms of aneuploidy in mammalian cells and methods used to detect chemica …
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a …
The role of exercise induced capillarization adaptations in skeletal muscle aging: a systematic review.
Ding Y, Wan Q, Kim JC, Liu W, Ji W. Ding Y, et al. Front Physiol. 2025 Sep 26;16:1681184. doi: 10.3389/fphys.2025.1681184. eCollection 2025. Front Physiol. 2025. PMID: 41078379 Free PMC article.
Studies involving exercise interventions in older adults were included, with the requirement that at least one original outcome related to skeletal muscle capillarization was reported. Articles were rigorously screened based on the PICOS criteria, and the quality of …
Studies involving exercise interventions in older adults were included, with the requirement that at least one original outcome relat …
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