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Adverse outcome pathways: From research to regulation scientific workshop report.
Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. Kleinstreuer NC, et al. Regul Toxicol Pharmacol. 2016 Apr;76:39-50. doi: 10.1016/j.yrtph.2016.01.007. Epub 2016 Jan 14. Regul Toxicol Pharmacol. 2016. PMID: 26774756 Free PMC article.
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductiv …
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular in …
Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework.
Chauhan V, Wilkins RC, Beaton D, Sachana M, Delrue N, Yauk C, O'Brien J, Marchetti F, Halappanavar S, Boyd M, Villeneuve D, Barton-Maclaren TS, Meek B, Anghel C, Heghes C, Barber C, Perkins E, Leblanc J, Burtt J, Laakso H, Laurier D, Lazo T, Whelan M, Thomas R, Cool D. Chauhan V, et al. Int J Radiat Biol. 2021;97(4):431-441. doi: 10.1080/09553002.2021.1884314. Epub 2021 Mar 1. Int J Radiat Biol. 2021. PMID: 33539251 Free PMC article.
To this end, a virtual workshop was held on 7 and 8 October 2020 with experts from the OECD AOP Programme together with the radiation and chemical research/regulation communities. The workshop was a coordinated effort of Health Canada, the Electric Pow …
To this end, a virtual workshop was held on 7 and 8 October 2020 with experts from the OECD AOP Programme together with the radiation …
Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.
Shatkin JA, Ong KJ, Beaudrie C, Clippinger AJ, Hendren CO, Haber LT, Hill M, Holden P, Kennedy AJ, Kim B, MacDonell M, Powers CM, Sharma M, Sheremeta L, Stone V, Sultan Y, Turley A, White RH. Shatkin JA, et al. Risk Anal. 2016 Aug;36(8):1520-37. doi: 10.1111/risa.12683. Epub 2016 Aug 11. Risk Anal. 2016. PMID: 27510619 Review.
Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coor …
Participants recognized that leadership is required from within the scientific community to address basic challenges, including stand …
Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework.
Qin SJ, Zeng QG, Zeng HX, Li SP, Andersson J, Zhao B, Oudin A, Kanninen KM, Jalava P, Jin NX, Yang M, Lin LZ, Liu RQ, Dong GH, Zeng XW. Qin SJ, et al. Sci Total Environ. 2024 Oct 15;947:174450. doi: 10.1016/j.scitotenv.2024.174450. Epub 2024 Jul 3. Sci Total Environ. 2024. PMID: 38969138 Review.
However, the underlying mechanism has not yet been fully illustrated due to the variety of the study models, different endpoints, etc. The adverse outcome pathway (AOP) framework is a pathway-based approach that could systematize mechanistic knowledge to assist heal …
However, the underlying mechanism has not yet been fully illustrated due to the variety of the study models, different endpoints, etc. The …
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth.
Marx-Stoelting P, Solano MLM, Aoyama H, Adams RH, Bal-Price A, Buschmann J, Chahoud I, Clark R, Fang T, Fujiwara M, Gelinsky M, Grote K, Horimoto M, Bennekou SH, Kellner R, Kuwagata M, Leist M, Lang A, Li W, Mantovani A, Makris SL, Paumgartten F, Perron M, Sachana M, Schmitt A, Schneider S, Schönfelder G, Schulze F, Shiota K, Solecki R. Marx-Stoelting P, et al. Reprod Toxicol. 2021 Mar;100:155-162. doi: 10.1016/j.reprotox.2020.11.003. Epub 2020 Dec 2. Reprod Toxicol. 2021. PMID: 33278556 Free PMC article.
25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together international experts from authorities, academia and industry to consider scientific, methodologic and regulatory aspects in risk assessment o …
25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together internati …
Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.
Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. Clippinger AJ, et al. Toxicol In Vitro. 2018 Apr;48:53-70. doi: 10.1016/j.tiv.2017.12.011. Epub 2017 Dec 22. Toxicol In Vitro. 2018. PMID: 29277654 Free PMC article.
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulatory Data Requirements", explored current testing requirements and ongoing efforts to achieve global regulatory acceptance for non-animal tes …
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulat …
Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop.
Aigner A, Buesen R, Gant T, Gooderham N, Greim H, Hackermüller J, Hubesch B, Laffont M, Marczylo E, Meister G, Petrick JS, Rasoulpour RJ, Sauer UG, Schmidt K, Seitz H, Slack F, Sukata T, van der Vies SM, Verhaert J, Witwer KW, Poole A. Aigner A, et al. Regul Toxicol Pharmacol. 2016 Dec;82:127-139. doi: 10.1016/j.yrtph.2016.09.018. Epub 2016 Sep 20. Regul Toxicol Pharmacol. 2016. PMID: 27663666 Free article.
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art research on noncoding RNAs (ncRNAs) as biomarkers in regulatory toxicology and as analytical and therapeutic agents. ...Applying a hol …
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art …
Ascertaining sensitive exposure biomarkers of various metal(loid)s to embryo implantation.
Ren M, Wu T, Yang S, Gao N, Lan C, Zhang H, Lin W, Su S, Yan L, Zhuang L, Lu Q, Xu J, Han B, Bai Z, Meng F, Chen Y, Pan B, Wang B, Lu X, Fang M. Ren M, et al. Environ Pollut. 2024 Apr 15;347:123679. doi: 10.1016/j.envpol.2024.123679. Epub 2024 Mar 8. Environ Pollut. 2024. PMID: 38462199
An analytical framework was established by integrating epidemiological association results, comprehensive literature searching, and knowledge-based adverse outcome pathway (AOP) networks. The sensitive biomarkers of metal(loid)s along with potential biological pa …
An analytical framework was established by integrating epidemiological association results, comprehensive literature searching, and knowledg …
Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Lynch AM, Eastmond D, Elhajouji A, Froetschl R, Kirsch-Volders M, Marchetti F, Masumura K, Pacchierotti F, Schuler M, Tweats D. Lynch AM, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Nov;847:403025. doi: 10.1016/j.mrgentox.2019.02.006. Epub 2019 Mar 2. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31699346 Review.
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a review of the scientific literature on the biological mechanisms of aneuploidy in mammalian cells and methods used to detect chemica …
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a …
Multiple bioanalytical methods reveal a thyroid-disrupting mechanism related to the membrane receptor integrin αvβ3.
Kong D, Li J, Li N, Zhang S, Xu Y. Kong D, et al. Environ Pollut. 2021 Jun 15;279:116933. doi: 10.1016/j.envpol.2021.116933. Epub 2021 Mar 17. Environ Pollut. 2021. PMID: 33773180
Moreover, DEHP activated the downstream extracellular regulated protein kinase (ERK1/2) pathway, upregulating the gene expression of raf-1, MEK-1 and MAPK1 and increasing the protein levels of p-ERK; interestingly, ERK1/2 activation and c-fos upregulation induced by DEHP w …
Moreover, DEHP activated the downstream extracellular regulated protein kinase (ERK1/2) pathway, upregulating the gene expression of …
11 results