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Adverse outcome pathways: From research to regulation scientific workshop report.
Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. Kleinstreuer NC, et al. Regul Toxicol Pharmacol. 2016 Apr;76:39-50. doi: 10.1016/j.yrtph.2016.01.007. Epub 2016 Jan 14. Regul Toxicol Pharmacol. 2016. PMID: 26774756
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductiv …
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular in …
Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.
Shatkin JA, Ong KJ, Beaudrie C, Clippinger AJ, Hendren CO, Haber LT, Hill M, Holden P, Kennedy AJ, Kim B, MacDonell M, Powers CM, Sharma M, Sheremeta L, Stone V, Sultan Y, Turley A, White RH. Shatkin JA, et al. Risk Anal. 2016 Aug;36(8):1520-37. doi: 10.1111/risa.12683. Epub 2016 Aug 11. Risk Anal. 2016. PMID: 27510619 Review.
Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coor …
Participants recognized that leadership is required from within the scientific community to address basic challenges, including stand …
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth.
Marx-Stoelting P, Solano MLM, Aoyama H, Adams RH, Bal-Price A, Buschmann J, Chahoud I, Clark R, Fang T, Fujiwara M, Gelinsky M, Grote K, Horimoto M, Bennekou SH, Kellner R, Kuwagata M, Leist M, Lang A, Li W, Mantovani A, Makris SL, Paumgartten F, Perron M, Sachana M, Schmitt A, Schneider S, Schönfelder G, Schulze F, Shiota K, Solecki R. Marx-Stoelting P, et al. Reprod Toxicol. 2021 Mar;100:155-162. doi: 10.1016/j.reprotox.2020.11.003. Epub 2020 Dec 2. Reprod Toxicol. 2021. PMID: 33278556 Free PMC article.
25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together international experts from authorities, academia and industry to consider scientific, methodologic and regulatory aspects in risk assessment o …
25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together internati …
Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.
Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. Clippinger AJ, et al. Toxicol In Vitro. 2018 Apr;48:53-70. doi: 10.1016/j.tiv.2017.12.011. Epub 2017 Dec 22. Toxicol In Vitro. 2018. PMID: 29277654 Free PMC article.
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulatory Data Requirements", explored current testing requirements and ongoing efforts to achieve global regulatory acceptance for non-animal tes …
A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulat …
Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.
Lynch AM, Eastmond D, Elhajouji A, Froetschl R, Kirsch-Volders M, Marchetti F, Masumura K, Pacchierotti F, Schuler M, Tweats D. Lynch AM, et al. Mutat Res Genet Toxicol Environ Mutagen. 2019 Nov;847:403025. doi: 10.1016/j.mrgentox.2019.02.006. Epub 2019 Mar 2. Mutat Res Genet Toxicol Environ Mutagen. 2019. PMID: 31699346 Review.
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a review of the scientific literature on the biological mechanisms of aneuploidy in mammalian cells and methods used to detect chemica …
An aneuploidy workgroup was established as part of the 7th International Workshops on Genotoxicity Testing. The workgroup conducted a …
Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop.
Aigner A, Buesen R, Gant T, Gooderham N, Greim H, Hackermüller J, Hubesch B, Laffont M, Marczylo E, Meister G, Petrick JS, Rasoulpour RJ, Sauer UG, Schmidt K, Seitz H, Slack F, Sukata T, van der Vies SM, Verhaert J, Witwer KW, Poole A. Aigner A, et al. Regul Toxicol Pharmacol. 2016 Dec;82:127-139. doi: 10.1016/j.yrtph.2016.09.018. Epub 2016 Sep 20. Regul Toxicol Pharmacol. 2016. PMID: 27663666 Free article.
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art research on noncoding RNAs (ncRNAs) as biomarkers in regulatory toxicology and as analytical and therapeutic agents. ...Applying a hol …
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art …
Multiple bioanalytical methods reveal a thyroid-disrupting mechanism related to the membrane receptor integrin αvβ3.
Kong D, Li J, Li N, Zhang S, Xu Y. Kong D, et al. Environ Pollut. 2021 Jun 15;279:116933. doi: 10.1016/j.envpol.2021.116933. Epub 2021 Mar 17. Environ Pollut. 2021. PMID: 33773180
All of these findings support the supposition that DEHP-induced thyroid-disrupting effects might be mediated by the membrane receptor integrin alpha(v)beta(3). Moreover, DEHP activated the downstream extracellular regulated protein kinase (ERK1/2) pathway, upregulating the …
All of these findings support the supposition that DEHP-induced thyroid-disrupting effects might be mediated by the membrane receptor integr …
The Amagugu intervention for disclosure of maternal HIV to uninfected primary school-aged children in South Africa: a randomised controlled trial.
Rochat TJ, Stein A, Cortina-Borja M, Tanser F, Bland RM. Rochat TJ, et al. Lancet HIV. 2017 Dec;4(12):e566-e576. doi: 10.1016/S2352-3018(17)30133-9. Epub 2017 Aug 23. Lancet HIV. 2017. PMID: 28843988 Clinical Trial.
The primary outcome was maternal HIV disclosure (full [using the word HIV], partial [using the word virus], or none) at 9 months post baseline. ...Further follow-up and effectiveness research is required. FUNDING: National Institutes of Health....
The primary outcome was maternal HIV disclosure (full [using the word HIV], partial [using the word virus], or none) at 9 months post …