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A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R. Berns K, et al. Nature. 2004 Mar 25;428(6981):431-7. doi: 10.1038/nature02371. Nature. 2004. PMID: 15042092
Immense promises for tiny molecules: uncovering miRNA functions.
le Sage C, Agami R. le Sage C, et al. Cell Cycle. 2006 Jul;5(13):1415-21. doi: 10.4161/cc.5.13.2890. Epub 2006 Jul 1. Cell Cycle. 2006. PMID: 16775415 Review.
Telomerase-independent regulation of ATR by human telomerase RNA.
Kedde M, le Sage C, Duursma A, Zlotorynski E, van Leeuwen B, Nijkamp W, Beijersbergen R, Agami R. Kedde M, et al. J Biol Chem. 2006 Dec 29;281(52):40503-14. doi: 10.1074/jbc.M607676200. Epub 2006 Nov 10. J Biol Chem. 2006. PMID: 17098743
BRD7 is a candidate tumour suppressor gene required for p53 function.
Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R, Del Sal G. Drost J, et al. Nat Cell Biol. 2010 Apr;12(4):380-9. doi: 10.1038/ncb2038. Epub 2010 Mar 14. Nat Cell Biol. 2010. PMID: 20228809
MicroRNA regulation by RNA-binding proteins and its implications for cancer.
van Kouwenhove M, Kedde M, Agami R. van Kouwenhove M, et al. Nat Rev Cancer. 2011 Aug 5;11(9):644-56. doi: 10.1038/nrc3107. Nat Rev Cancer. 2011. PMID: 21822212 Review.
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.
Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R. Léveillé N, et al. Nat Commun. 2011 Oct 25;2:513. doi: 10.1038/ncomms1519. Nat Commun. 2011. PMID: 22027593 Free PMC article.
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites.
Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kühn U, Menzies FM, Oude Vrielink JA, Bos AJ, Drost J, Rooijers K, Rubinsztein DC, Agami R. Jenal M, et al. Cell. 2012 Apr 27;149(3):538-53. doi: 10.1016/j.cell.2012.03.022. Epub 2012 Apr 12. Cell. 2012. PMID: 22502866
Alternative cleavage and polyadenylation during colorectal cancer development.
Morris AR, Bos A, Diosdado B, Rooijers K, Elkon R, Bolijn AS, Carvalho B, Meijer GA, Agami R. Morris AR, et al. Clin Cancer Res. 2012 Oct 1;18(19):5256-66. doi: 10.1158/1078-0432.CCR-12-0543. Epub 2012 Aug 8. Clin Cancer Res. 2012. PMID: 22874640
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