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Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels.
Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Singh RP, et al. Among authors: Agarwal C, Agarwal R. Cancer Res. 2002 Jun 1;62(11):3063-9. Cancer Res. 2002. PMID: 12036915

Dietary feeding of silibinin at 0.05 and 0.1% doses (w/w) for 60 days, 24 h after s.c. DU145 tumor xenograft implantation in athymic male nude mice, significantly inhibited tumor volume by 35 and 58% (P < 0.05), and wet weight of tumor by 29 and 40% (P < 0.05), respe

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Dietary feeding of silibinin at 0.05 and 0.1% doses (w/w) for 60 days, 24 h after s.c. DU145 tumor xenograft implantation in athymic …
Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.
Agarwal C, Singh RP, Agarwal R. Agarwal C, et al. Among authors: Agarwal R. Carcinogenesis. 2002 Nov;23(11):1869-76. doi: 10.1093/carcin/23.11.1869. Carcinogenesis. 2002. PMID: 12419835
Upstream of caspase cascade, GSE showed disappearance of mitochondrial membrane potential and an increase in cytochrome c release in cytosol. Together, these results suggest that GSE possibly causes mitochondrial damage leading to cytochrome c release in cytosol and …
Upstream of caspase cascade, GSE showed disappearance of mitochondrial membrane potential and an increase in cytochrome c release in …
Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.
Singh RP, Sharma G, Dhanalakshmi S, Agarwal C, Agarwal R. Singh RP, et al. Among authors: Agarwal C, Agarwal R. Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):933-9. Cancer Epidemiol Biomarkers Prev. 2003. PMID: 14504208
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Agarwal C, Singh RP, Dhanalakshmi S, Tyagi AK, Tecklenburg M, Sclafani RA, Agarwal R. Agarwal C, et al. Among authors: Agarwal R. Oncogene. 2003 Nov 13;22(51):8271-82. doi: 10.1038/sj.onc.1207158. Oncogene. 2003. PMID: 14614451
This observation was further confirmed by the findings showing a lack in caspases activity increase and caspases and PARP cleavage as well as a lack in cytochrome c release in cytosol following silibinin treatment of HT-29 cells. ...
This observation was further confirmed by the findings showing a lack in caspases activity increase and caspases and PARP cleavage as well a …
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