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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Agarwal N, et al. Nat Neurosci. 2007 Jul;10(7):870-9. doi: 10.1038/nn1916. Epub 2007 Jun 10. Nat Neurosci. 2007. PMID: 17558404 Free PMC article.
Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, MacDermott AB, Lewin GR, Kuner R. Gangadharan V, et al. Among authors: agarwal n. J Clin Invest. 2011 Apr;121(4):1608-23. doi: 10.1172/JCI44911. Epub 2011 Mar 7. J Clin Invest. 2011. PMID: 21383497 Free PMC article.
Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.
Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, Kuner R. Tappe-Theodor A, et al. Among authors: agarwal n. Pain. 2012 Jan;153(1):184-196. doi: 10.1016/j.pain.2011.10.014. Epub 2011 Nov 8. Pain. 2012. PMID: 22071319
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R. Luo C, et al. Among authors: agarwal n. PLoS Biol. 2012;10(3):e1001283. doi: 10.1371/journal.pbio.1001283. Epub 2012 Mar 13. PLoS Biol. 2012. PMID: 22427743 Free PMC article.
2,130 results