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Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Macdougall DA, Agarwal SR, Stopford EA, Chu H, Collins JA, Longster AL, Colyer J, Harvey RD, Calaghan S. Macdougall DA, et al. Among authors: agarwal sr. J Mol Cell Cardiol. 2012 Feb;52(2):388-400. doi: 10.1016/j.yjmcc.2011.06.014. Epub 2011 Jun 26. J Mol Cell Cardiol. 2012. PMID: 21740911 Free PMC article.
Role of membrane microdomains in compartmentation of cAMP signaling.
Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. Agarwal SR, et al. PLoS One. 2014 Apr 21;9(4):e95835. doi: 10.1371/journal.pone.0095835. eCollection 2014. PLoS One. 2014. PMID: 24752595 Free PMC article.
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