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Page 1
Showing results for ager in
Your search for Agera SIN retrieved no results
AGER-dependent macropinocytosis drives resistance to KRAS-G12D-targeted therapy in advanced pancreatic cancer.
Li C, Liu Y, Liu C, Chen F, Xie Y, Zeh HJ, Yu C, Liu J, Tang D, Kang R. Li C, et al. Sci Transl Med. 2025 Jan 29;17(783):eadp4986. doi: 10.1126/scitranslmed.adp4986. Epub 2025 Jan 29. Sci Transl Med. 2025. PMID: 39879317
Here, we report that the advanced glycosylation end product-specific receptor (AGER) plays a key role in mediating MRTX1133 resistance in PDAC cells. The up-regulation of AGER within cancer cells instigates macropinocytosis, facilitating the internalization of serum …
Here, we report that the advanced glycosylation end product-specific receptor (AGER) plays a key role in mediating MRTX1133 resistanc …
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver.
Fan W, Adebowale K, Váncza L, Li Y, Rabbi MF, Kunimoto K, Chen D, Mozes G, Chiu DK, Li Y, Tao J, Wei Y, Adeniji N, Brunsing RL, Dhanasekaran R, Singhi A, Geller D, Lo SH, Hodgson L, Engleman EG, Charville GW, Charu V, Monga SP, Kim T, Wells RG, Chaudhuri O, Török NJ. Fan W, et al. Nature. 2024 Feb;626(7999):635-642. doi: 10.1038/s41586-023-06991-9. Epub 2024 Jan 31. Nature. 2024. PMID: 38297127 Free PMC article.
AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis.
Chen R, Zhu S, Zeng L, Wang Q, Sheng Y, Zhou B, Tang D, Kang R. Chen R, et al. Front Immunol. 2019 Aug 8;10:1904. doi: 10.3389/fimmu.2019.01904. eCollection 2019. Front Immunol. 2019. PMID: 31440260 Free PMC article.
The inhibition of AGER-mediated lipid peroxidation via arachidonate 5-lipoxygenase (ALOX5) limits caspase-11 inflammasome activation and pyroptosis in macrophages in response to nDAMPs or cytosolic lipopolysaccharide. Importantly, the pharmacologic inhibition of the AGE …
The inhibition of AGER-mediated lipid peroxidation via arachidonate 5-lipoxygenase (ALOX5) limits caspase-11 inflammasome activation …
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
Strickson S, Houslay KF, Negri VA, Ohne Y, Ottosson T, Dodd RB, Huntington CC, Baker T, Li J, Stephenson KE, O'Connor AJ, Sagawe JS, Killick H, Moore T, Rees DG, Koch S, Sanden C, Wang Y, Gubbins E, Ghaedi M, Kolbeck R, Saumyaa S, Erjefält JS, Sims GP, Humbles AA, Scott IC, Romero Ros X, Cohen ES. Strickson S, et al. Eur Respir J. 2023 Sep 28;62(3):2202210. doi: 10.1183/13993003.02210-2022. Print 2023 Sep. Eur Respir J. 2023. PMID: 37442582 Free PMC article.
Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?-a review.
Ahuja P, Waris A, Siddiqui SS, Mukherjee A. Ahuja P, et al. J Genet Eng Biotechnol. 2022 Jan 31;20(1):17. doi: 10.1186/s43141-022-00297-5. J Genet Eng Biotechnol. 2022. PMID: 35099614 Free PMC article. Review.
OVERVIEW AND METHODOLOGY: This review discusses the existing literature on the association between single nucleotide variants (SNV) of AGER gene and the risk of DR. It also discusses the current understanding of the AGE-AGER pathway in diabetic retinopathy. ...Addit …
OVERVIEW AND METHODOLOGY: This review discusses the existing literature on the association between single nucleotide variants (SNV) of AG …
Inhibiting HMGB1/AGER/NF-kappaB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.
Hu C, Cui T, Xu Z, Yang K, Wu Y, Cai W, Yu J, Qiu Y. Hu C, et al. Int Immunopharmacol. 2025 Mar 6;149:114192. doi: 10.1016/j.intimp.2025.114192. Epub 2025 Feb 3. Int Immunopharmacol. 2025. PMID: 39904032 Free article.
Glycyrrhizin was used to inhibit HMGB1, while FPS-ZM1 served as an inhibitor of the receptor for advanced glycation end products (AGER). Microglial polarization was evaluated by QPCR, and the HMGB1/ AGER/ NF-kappaB signaling pathway was analyzed through WB. ...Glycy …
Glycyrrhizin was used to inhibit HMGB1, while FPS-ZM1 served as an inhibitor of the receptor for advanced glycation end products (AGER …
EDITORIAL.
Ahmad S, Shahab U, Moinuddin. Ahmad S, et al. Semin Cancer Biol. 2018 Apr;49:iii-iv. doi: 10.1016/j.semcancer.2018.03.002. Semin Cancer Biol. 2018. PMID: 29674153 No abstract available.
AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers.
Faiz A, van den Berge M, Vermeulen CJ, Ten Hacken NHT, Guryev V, Pouwels SD. Faiz A, et al. Respir Res. 2019 Apr 10;20(1):70. doi: 10.1186/s12931-019-1038-6. Respir Res. 2019. PMID: 30971245 Free PMC article.
In the current study, we investigated the effect of smoking on AGER, the gene encoding RAGE, expression and on alternative splicing of AGER. To this end, we conducted RNA-Seq on bronchial biopsies for asymptomatic smokers (n = 36) and never smokers (n = 40). ...We f …
In the current study, we investigated the effect of smoking on AGER, the gene encoding RAGE, expression and on alternative splicing o …
AGER promotes proliferation and migration in cervical cancer.
Zhu X, Zhou L, Li R, Shen Q, Cheng H, Shen Z, Zhu H. Zhu X, et al. Biosci Rep. 2018 Jan 30;38(1):BSR20171329. doi: 10.1042/BSR20171329. Print 2018 Feb 28. Biosci Rep. 2018. PMID: 29298878 Free PMC article.
We have previously reported that AGER was overexpressed in squamous cervical cancer. However, mechanisms of AGER involved in the progression of cervical cancer are unknown. ...AGER protein primarily localized in the cytoplasm and cytomembrane of cervical squa …
We have previously reported that AGER was overexpressed in squamous cervical cancer. However, mechanisms of AGER involved in t …
Association of AGER genetic variants with chronic obstructive pulmonary disease susceptibility in Southern Chinese Han populations.
Xie T, Xiao W, Zhao J, Zheng Y, Ding Y, Zeng M. Xie T, et al. Ann Med. 2025 Dec;57(1):2548974. doi: 10.1080/07853890.2025.2548974. Epub 2025 Sep 1. Ann Med. 2025. PMID: 40889521 Free PMC article.
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) remains a leading cause of disability and mortality among elderly populations. Studies indicate that AGER plays a critical regulatory role in the pathogenesis of respiratory disorders. However, the genetic variations …
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) remains a leading cause of disability and mortality among elderly populations. Studi …
2,433 results