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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1968 1
1973 1
1974 1
1975 1
1978 1
1979 4
1981 1
1982 2
1984 1
1985 1
1986 2
1990 2
1992 1
1993 3
1994 1
1995 3
1996 6
1997 8
1998 6
1999 11
2000 11
2001 9
2002 18
2003 26
2004 31
2005 38
2006 41
2007 65
2008 98
2009 140
2010 147
2011 168
2012 184
2013 191
2014 173
2015 185
2016 204
2017 195
2018 221
2019 281
2020 285
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2022 287
2023 354
2024 350
2025 336
2026 85

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2,564 results

Results by year

Filters applied: in the last 10 years, Free full text, English, Humans. Clear all
Page 1
An epigenetic biomarker of aging for lifespan and healthspan.
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. Levine ME, et al. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. Aging (Albany NY). 2018. PMID: 29676998 Free PMC article.
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical m …
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of ag …
The human gut microbiome and aging.
Bradley E, Haran J. Bradley E, et al. Gut Microbes. 2024 Jan-Dec;16(1):2359677. doi: 10.1080/19490976.2024.2359677. Epub 2024 Jun 3. Gut Microbes. 2024. PMID: 38831607 Free PMC article. Review.
From birth, it is shaped by mode of delivery, diet, environmental exposures, geographic location, exposures to medications, and by aging itself. Here, we present a narrative review of the gut microbiome across the lifespan with a focus on its impacts on aging and ag …
From birth, it is shaped by mode of delivery, diet, environmental exposures, geographic location, exposures to medications, and by aging …
Genetics and Epigenetics in Aging and Longevity: Myths and Truths.
Ren J, Zhang Y. Ren J, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1715-1717. doi: 10.1016/j.bbadis.2019.02.005. Epub 2019 Feb 21. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30799263 Free article. No abstract available.
Epigenetic Mechanisms of Longevity and Aging.
Sen P, Shah PP, Nativio R, Berger SL. Sen P, et al. Cell. 2016 Aug 11;166(4):822-839. doi: 10.1016/j.cell.2016.07.050. Cell. 2016. PMID: 27518561 Free PMC article. Review.
Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. ...We establish links between common ope …
Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, …
Mitochondria in Ovarian Aging and Reproductive Longevity.
Chiang JL, Shukla P, Pagidas K, Ahmed NS, Karri S, Gunn DD, Hurd WW, Singh KK. Chiang JL, et al. Ageing Res Rev. 2020 Nov;63:101168. doi: 10.1016/j.arr.2020.101168. Epub 2020 Sep 4. Ageing Res Rev. 2020. PMID: 32896666 Free PMC article. Review.
There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also reported during ovarian aging. However, the mitochondrial mechanisms contributing to ovarian aging and infertility are not fully …
There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also re …
Plasma proteomics links brain and immune system aging with healthspan and longevity.
Oh HS, Le Guen Y, Rappoport N, Urey DY, Farinas A, Rutledge J, Channappa D, Wagner AD, Mormino E, Brunet A, Greicius MD, Wyss-Coray T. Oh HS, et al. Nat Med. 2025 Aug;31(8):2703-2711. doi: 10.1038/s41591-025-03798-1. Epub 2025 Jul 9. Nat Med. 2025. PMID: 40634782 Free PMC article.
Accrual of aged organs progressively increased mortality risk (2-4 aged organs, HR = 2.3; 5-7 aged organs, HR = 4.5; 8+ aged organs, HR = 8.3), whereas youthful brains and immune systems were uniquely associated with longevity (youthful brain, HR = 0.60 for mortality risk; …
Accrual of aged organs progressively increased mortality risk (2-4 aged organs, HR = 2.3; 5-7 aged organs, HR = 4.5; 8+ aged organs, HR = 8. …
Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care.
Haykal D, Flament F, Mora P, Balooch G, Cartier H. Haykal D, et al. Int J Dermatol. 2025 Dec;64(12):2204-2214. doi: 10.1111/ijd.17725. Epub 2025 Mar 10. Int J Dermatol. 2025. PMID: 40064617 Free PMC article. Review.
The concept of aging has evolved from being primarily attributed to genetic factors to recognizing the critical role of epigenetic mechanisms. ...This review explores the interplay of epigenetic changes, aging, and the potential of personalized care to enhanc …
The concept of aging has evolved from being primarily attributed to genetic factors to recognizing the critical role of epigen …
Glycine and aging: Evidence and mechanisms.
Johnson AA, Cuellar TL. Johnson AA, et al. Ageing Res Rev. 2023 Jun;87:101922. doi: 10.1016/j.arr.2023.101922. Epub 2023 Mar 31. Ageing Res Rev. 2023. PMID: 37004845 Free article. Review.
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, glycine was found to boost longevity in genetically heterogenous mice. This simple amino acid similarly extends lifespan in r …
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, …
Plasma proteomics identify novel biomarkers and dynamic patterns of biological aging.
Ma LZ, Liu WS, He Y, Zhang Y, You J, Feng JF, Tan L, Cheng W, Yu JT. Ma LZ, et al. J Adv Res. 2026 Feb;80:691-704. doi: 10.1016/j.jare.2025.05.004. Epub 2025 May 4. J Adv Res. 2026. PMID: 40328427 Free PMC article.
INTRODUCTION: Plasma proteomics examines levels of thousands of proteins and has the potential to identify clinical biomarkers for healthy aging. OBJECTIVES: This large proteomics study aims to identify clinical biomarkers for healthy aging and further explore poten …
INTRODUCTION: Plasma proteomics examines levels of thousands of proteins and has the potential to identify clinical biomarkers for healthy …
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.
Field AE, Robertson NA, Wang T, Havas A, Ideker T, Adams PD. Field AE, et al. Mol Cell. 2018 Sep 20;71(6):882-895. doi: 10.1016/j.molcel.2018.08.008. Mol Cell. 2018. PMID: 30241605 Free PMC article. Review.
Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. Recent studies have identified collections of individual methylation sites whose aggregate methylation status measures chronological age, ref …
Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. R …
2,564 results