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Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds.
Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW. Zhang X, et al. J Mol Med (Berl). 2011 Oct;89(10):985-95. doi: 10.1007/s00109-011-0754-2. Epub 2011 Apr 16. J Mol Med (Berl). 2011. PMID: 21499736 Free PMC article.
Neovascularization is an essential step in wound healing, and bone marrow-derived angiogenic cells (BMDACs) play an important role in vascularization. ...Our results indicate that aging impairs burn wound vascu …
Neovascularization is an essential step in wound healing, and bone marrow-derived angiogenic cells
Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice.
Du J, Liu L, Lay F, Wang Q, Dou C, Zhang X, Hosseini SM, Simon A, Rees DJ, Ahmed AK, Sebastian R, Sarkar K, Milner S, Marti GP, Semenza GL, Harmon JW. Du J, et al. Gene Ther. 2013 Nov;20(11):1070-6. doi: 10.1038/gt.2013.32. Epub 2013 Jun 20. Gene Ther. 2013. PMID: 23784441
Its actions in dermal wounds promote angiogenesis and improve healing. In a murine burn wound model, aged mice had impaired wound healing associated with reduced levels of HIF-1. When gene therapy with HIF-1 alone did not correct these deficits, …
Its actions in dermal wounds promote angiogenesis and improve healing. In a murine burn wound model, aged mice had i
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