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Replication stress and cancer.
Gaillard H, García-Muse T, Aguilera A. Gaillard H, et al. Nat Rev Cancer. 2015 May;15(5):276-89. doi: 10.1038/nrc3916. Nat Rev Cancer. 2015. PMID: 25907220 Review.
Any condition leading to high levels of DNA damage will result in replication stress, which is a source of genome instability and a feature of pre-cancerous and cancerous cells. ...Although a negative aspect of replication stress is its prominent role in tumo …
Any condition leading to high levels of DNA damage will result in replication stress, which is a source of genome instability and …
Double-strand break repair: are Rad51/RecA--DNA joints barriers to DNA replication?
Aguilera A. Aguilera A. Trends Genet. 2001 Jun;17(6):318-21. doi: 10.1016/s0168-9525(01)02309-5. Trends Genet. 2001. PMID: 11377793 Review.
However, what causes a DNA end to be repaired via SDSA or via BIR/RDR? I propose that Rad51/RecA--DNA plectonemic joints act as barriers to DNA replication and that BIR/RDR is only possible when the DNA polymerase that synthesizes DNA from the invading 3' end does not enco …
However, what causes a DNA end to be repaired via SDSA or via BIR/RDR? I propose that Rad51/RecA--DNA plectonemic joints act as barri …
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants.
González-Barrera S, Prado F, Verhage R, Brouwer J, Aguilera A. González-Barrera S, et al. Nucleic Acids Res. 2002 May 15;30(10):2193-201. doi: 10.1093/nar/30.10.2193. Nucleic Acids Res. 2002. PMID: 12000839 Free PMC article.
It is thought that elongating RNAPII, stalled at a DNA lesion, is used for the loading of the NER machinery in a process termed transcription-coupled repair (TCR). ...We have previously defined a number of yeast genes, whose deletions confer transcription-dep …
It is thought that elongating RNAPII, stalled at a DNA lesion, is used for the loading of the NER machinery in a process terme …
Mitotic recombination in Saccharomyces cerevisiae.
Prado F, Cortés-Ledesma F, Huertas P, Aguilera A. Prado F, et al. Curr Genet. 2003 Jan;42(4):185-98. doi: 10.1007/s00294-002-0346-3. Epub 2002 Nov 29. Curr Genet. 2003. PMID: 12589470 Review.
The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange.
Prado F, Cortés-Ledesma F, Aguilera A. Prado F, et al. EMBO Rep. 2004 May;5(5):497-502. doi: 10.1038/sj.embor.7400128. Epub 2004 Apr 8. EMBO Rep. 2004. PMID: 15071494 Free PMC article.
In accordance with a defect in nucleosome assembly, asf1Delta leads to a loss of negative supercoiling in plasmids. Importantly, asf1Delta increases spontaneous recombination between inverted DNA sequences. ...
In accordance with a defect in nucleosome assembly, asf1Delta leads to a loss of negative supercoiling in plasmids. Importantl …
Partial depletion of histone H4 increases homologous recombination-mediated genetic instability.
Prado F, Aguilera A. Prado F, et al. Mol Cell Biol. 2005 Feb;25(4):1526-36. doi: 10.1128/MCB.25.4.1526-1536.2005. Mol Cell Biol. 2005. PMID: 15684401 Free PMC article.
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome assembly, we analyzed the effect of a partial depletion of histone H4 on genetic instability mediated by homologous recombination. A Sacc …
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome assembly, w …
Impairment of replication fork progression mediates RNA polII transcription-associated recombination.
Prado F, Aguilera A. Prado F, et al. EMBO J. 2005 Mar 23;24(6):1267-76. doi: 10.1038/sj.emboj.7600602. Epub 2005 Mar 3. EMBO J. 2005. PMID: 15775982 Free PMC article.
RNAPII transcription concomitant to head-on oncoming replication causes a replication fork pause (RFP) that is linked to a significant increase in recombination. ...
RNAPII transcription concomitant to head-on oncoming replication causes a replication fork pause (RFP) that is linked to a sig …
Interdependence between transcription and mRNP processing and export, and its impact on genetic stability.
Luna R, Jimeno S, Marín M, Huertas P, García-Rubio M, Aguilera A. Luna R, et al. Mol Cell. 2005 Jun 10;18(6):711-22. doi: 10.1016/j.molcel.2005.05.001. Mol Cell. 2005. PMID: 15949445
Nevertheless, mutants in 3' end cleavage/polyadenylation, nuclear exosome, and mRNA export showed a weak but significant effect on recombination and transcript accumulation. ...The results suggest a tight interdependence among mRNP biogenesis steps and transcription …
Nevertheless, mutants in 3' end cleavage/polyadenylation, nuclear exosome, and mRNA export showed a weak but significant effect on re …
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.
Wellinger RE, Prado F, Aguilera A. Wellinger RE, et al. Mol Cell Biol. 2006 Apr;26(8):3327-34. doi: 10.1128/MCB.26.8.3327-3334.2006. Mol Cell Biol. 2006. PMID: 16581804 Free PMC article.
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein (mRNP) metabolism. ...Our results link transcription-dependent genomic instability in THO mutants with impaired replication fork progression …
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein …
Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange.
Cortés-Ledesma F, Aguilera A. Cortés-Ledesma F, et al. EMBO Rep. 2006 Sep;7(9):919-26. doi: 10.1038/sj.embor.7400774. Epub 2006 Aug 4. EMBO Rep. 2006. PMID: 16888651 Free PMC article.
To study repair of replication-born DSBs, we defined a system in Saccharomyces cerevisiae for the induction of a site-specific single-strand break. We show that a 21-base pair (bp) HO site is cleaved at only one strand by the HO endonuclease, with the resulti …
To study repair of replication-born DSBs, we defined a system in Saccharomyces cerevisiae for the induction of a site-specific …
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