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DNA-RNA hybrids: the risks of DNA breakage during transcription.
Aguilera A, Gómez-González B. Aguilera A, et al. Nat Struct Mol Biol. 2017 May 4;24(5):439-443. doi: 10.1038/nsmb.3395. Nat Struct Mol Biol. 2017. PMID: 28471430
Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes.
Prado F, Aguilera A. Prado F, et al. Among authors: aguilera a. Genetics. 1995 Jan;139(1):109-23. Genetics. 1995. PMID: 7705617 Free PMC article.
This difference can be explained by the observation that deletion events can be mediated by a recombination mechanism that can initiate within the intervening sequence of the repeats. ...SSA events to overall spontaneous deletions is a feature specific for each repe …
This difference can be explained by the observation that deletion events can be mediated by a recombination mechanism that can initia …
Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation.
Santos-Rosa H, Aguilera A. Santos-Rosa H, et al. Among authors: aguilera a. Genetics. 1995 Jan;139(1):57-66. Genetics. 1995. PMID: 7705651 Free PMC article.
None of the mutations has a clear effect on the levels of spontaneous and double-strand break-induced deletions. Among other characteristics we have found are the following: (1) one mutation, hrs1-1, reduces the frequency of deletions in rad52-1 strains 20-fold, suggesting …
None of the mutations has a clear effect on the levels of spontaneous and double-strand break-induced deletions. Among other characte …
Increase in incidence of chromosome instability and non-conservative recombination between repeats in Saccharomyces cerevisiae hpr1 delta strains.
Santos-Rosa H, Aguilera A. Santos-Rosa H, et al. Among authors: aguilera a. Mol Gen Genet. 1994 Oct 28;245(2):224-36. doi: 10.1007/BF00283271. Mol Gen Genet. 1994. PMID: 7816031
Null hpr1 delta strains show a large increase (up to 2000-fold) over wild type in the frequency of occurrence of deletions between direct repeats on three different chromosomes. ...A novel intrachromosomal recombination system has allowed us to determine that over 9 …
Null hpr1 delta strains show a large increase (up to 2000-fold) over wild type in the frequency of occurrence of deletions between di …
Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair.
Piruat JI, Aguilera A. Piruat JI, et al. Among authors: aguilera a. Genetics. 1996 Aug;143(4):1533-42. Genetics. 1996. PMID: 8844143 Free PMC article.
We have obtained genetic and molecular evidence that the hrs2-1 mutation, isolated as a suppressor of the hyperrecombination phenotype of hpr1 delta, is in the SRB2 gene, which encodes a component of the RNA polII holoenzyme. ...We discuss the possibility that hpr1- …
We have obtained genetic and molecular evidence that the hrs2-1 mutation, isolated as a suppressor of the hyperrecombination phenotyp …
The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats.
Santos-Rosa H, Clever B, Heyer WD, Aguilera A. Santos-Rosa H, et al. Among authors: aguilera a. Genetics. 1996 Mar;142(3):705-16. Genetics. 1996. PMID: 8849881 Free PMC article.
We have purified a His(6) tagged version of Hrs1p protein from E. coli and have obtained specific anti-Hrs1p polyclonal antibodies. We show that Hrs1p is a 49-kD nuclear protein, as determined by indirect immunofluorescence microscopy and Western blot analysis. ...
We have purified a His(6) tagged version of Hrs1p protein from E. coli and have obtained specific anti-Hrs1p polyclonal antibodies. W …
Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation.
Prado F, Piruat JI, Aguilera A. Prado F, et al. Among authors: aguilera a. EMBO J. 1997 May 15;16(10):2826-35. doi: 10.1093/emboj/16.10.2826. EMBO J. 1997. PMID: 9184227 Free PMC article.
Here we provide genetic and molecular evidence for a specific mechanism of stimulation of recombination by transcription. We show that the induction of deletions between repeats in hpr1delta cells of Saccharomyces cerevisiae is linked to transcription elongation. ...Both t …
Here we provide genetic and molecular evidence for a specific mechanism of stimulation of recombination by transcription. We show tha …
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability.
Chávez S, Aguilera A. Chávez S, et al. Among authors: aguilera a. Genes Dev. 1997 Dec 15;11(24):3459-70. doi: 10.1101/gad.11.24.3459. Genes Dev. 1997. PMID: 9407037 Free PMC article.
We show that HPR1 is not required for transcription activation and that the previously reported effects of hpr1Delta on the activation of different promoters is a consequence of the incapacity of hpr1Delta cells to elongate transcription through lacZ, used as reporter. ... …
We show that HPR1 is not required for transcription activation and that the previously reported effects of hpr1Delta on the activation of di …
The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11.
Piruat JI, Chávez S, Aguilera A. Piruat JI, et al. Among authors: aguilera a. Genetics. 1997 Dec;147(4):1585-94. Genetics. 1997. PMID: 9409823 Free PMC article.
We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination phenotype of hpr1, has positive and negative roles in transcriptional regulation. ...We discuss the possibility that Hrs1p might be a com …
We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination phen …
A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.
Piruat JI, Aguilera A. Piruat JI, et al. Among authors: aguilera a. EMBO J. 1998 Aug 17;17(16):4859-72. doi: 10.1093/emboj/17.16.4859. EMBO J. 1998. PMID: 9707445 Free PMC article.
The higher the impairment of transcription caused by tho2Delta, the higher the frequency of recombination of a particular DNA region. ...Our work not only identifies a novel yeast gene, THO2, with similar function to HPR1, but also provides new evidence for transcri …
The higher the impairment of transcription caused by tho2Delta, the higher the frequency of recombination of a particular DNA region. …
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