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The need to regulate replication fork speed.
Gómez-González B, Aguilera A. Gómez-González B, et al. Science. 2017 Nov 10;358(6364):722-723. doi: 10.1126/science.aaq0678. Science. 2017. PMID: 29123052 No abstract available.
Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes.
Prado F, Aguilera A. Prado F, et al. Genetics. 1995 Jan;139(1):109-23. Genetics. 1995. PMID: 7705617 Free PMC article.
This difference can be explained by the observation that deletion events can be mediated by a recombination mechanism that can initiate within the intervening sequence of the repeats. ...SSA events to overall spontaneous deletions is a feature specific for each repe …
This difference can be explained by the observation that deletion events can be mediated by a recombination mechanism that can initia …
Double-strand break repair: are Rad51/RecA--DNA joints barriers to DNA replication?
Aguilera A. Aguilera A. Trends Genet. 2001 Jun;17(6):318-21. doi: 10.1016/s0168-9525(01)02309-5. Trends Genet. 2001. PMID: 11377793 Review.
However, what causes a DNA end to be repaired via SDSA or via BIR/RDR? I propose that Rad51/RecA--DNA plectonemic joints act as barriers to DNA replication and that BIR/RDR is only possible when the DNA polymerase that synthesizes DNA from the invading 3' end does not enco …
However, what causes a DNA end to be repaired via SDSA or via BIR/RDR? I propose that Rad51/RecA--DNA plectonemic joints act as barri …
Transcription and double-strand breaks induce similar mitotic recombination events in Saccharomyces cerevisiae.
González-Barrera S, García-Rubio M, Aguilera A. González-Barrera S, et al. Genetics. 2002 Oct;162(2):603-14. Genetics. 2002. PMID: 12399375 Free PMC article.
We have made a comparative analysis of double-strand-break (DSB)-induced recombination and spontaneous recombination under low- and high-transcription conditions in yeast. ...Such substrates were based on the same leu2-HOr allele fused to the tet promoter and containing …
We have made a comparative analysis of double-strand-break (DSB)-induced recombination and spontaneous recombination under low- and h …
Equal sister chromatid exchange is a major mechanism of double-strand break repair in yeast.
González-Barrera S, Cortés-Ledesma F, Wellinger RE, Aguilera A. González-Barrera S, et al. Mol Cell. 2003 Jun;11(6):1661-71. doi: 10.1016/s1097-2765(03)00183-7. Mol Cell. 2003. PMID: 12820977
We show that equal SCE is a major mechanism of DSB repair, is Rad51 dependent, and is stimulated by Rad59 and Mre11. Our work provides a physical analysis of mitotically occurring SCE in vivo and opens new perspectives for the study and understanding of DSB repair i …
We show that equal SCE is a major mechanism of DSB repair, is Rad51 dependent, and is stimulated by Rad59 and Mre11. Our work provide …
Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae. New insights into transcription-associated recombination.
García-Rubio M, Huertas P, González-Barrera S, Aguilera A. García-Rubio M, et al. Genetics. 2003 Oct;165(2):457-66. Genetics. 2003. PMID: 14573461 Free PMC article.
Homologous recombination of a particular DNA sequence is strongly stimulated by transcription, a phenomenon observed from bacteria to mammals, which we refer to as transcription-associated recombination (TAR). ...Using different plasmid-chromosome and direct-repeat …
Homologous recombination of a particular DNA sequence is strongly stimulated by transcription, a phenomenon observed from bact …
The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange.
Prado F, Cortés-Ledesma F, Aguilera A. Prado F, et al. EMBO Rep. 2004 May;5(5):497-502. doi: 10.1038/sj.embor.7400128. Epub 2004 Apr 8. EMBO Rep. 2004. PMID: 15071494 Free PMC article.
In accordance with a defect in nucleosome assembly, asf1Delta leads to a loss of negative supercoiling in plasmids. Importantly, asf1Delta increases spontaneous recombination between inverted DNA sequences. ...
In accordance with a defect in nucleosome assembly, asf1Delta leads to a loss of negative supercoiling in plasmids. Importantl …
Partial depletion of histone H4 increases homologous recombination-mediated genetic instability.
Prado F, Aguilera A. Prado F, et al. Mol Cell Biol. 2005 Feb;25(4):1526-36. doi: 10.1128/MCB.25.4.1526-1536.2005. Mol Cell Biol. 2005. PMID: 15684401 Free PMC article.
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome assembly, we analyzed the effect of a partial depletion of histone H4 on genetic instability mediated by homologous recombination. A Sacc …
DNA replication can be a source of genetic instability. Given the tight connection between DNA replication and nucleosome assembly, w …
Impairment of replication fork progression mediates RNA polII transcription-associated recombination.
Prado F, Aguilera A. Prado F, et al. EMBO J. 2005 Mar 23;24(6):1267-76. doi: 10.1038/sj.emboj.7600602. Epub 2005 Mar 3. EMBO J. 2005. PMID: 15775982 Free PMC article.
RNAPII transcription concomitant to head-on oncoming replication causes a replication fork pause (RFP) that is linked to a significant increase in recombination. ...
RNAPII transcription concomitant to head-on oncoming replication causes a replication fork pause (RFP) that is linked to a sig …
Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.
Wellinger RE, Prado F, Aguilera A. Wellinger RE, et al. Mol Cell Biol. 2006 Apr;26(8):3327-34. doi: 10.1128/MCB.26.8.3327-3334.2006. Mol Cell Biol. 2006. PMID: 16581804 Free PMC article.
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein (mRNP) metabolism. ...Our results link transcription-dependent genomic instability in THO mutants with impaired replication fork progression …
THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein …
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