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Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption.
Chenoweth MJ, Zhu AZ, Sanderson Cox L, Ahluwalia JS, Benowitz NL, Tyndale RF. Chenoweth MJ, et al. Among authors: ahluwalia js. Pharmacogenet Genomics. 2014 Mar;24(3):172-6. doi: 10.1097/FPC.0000000000000031. Pharmacogenet Genomics. 2014. PMID: 24448396 Free PMC article.
Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.
Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW Jr, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF; PGRN-PNAT Research Group. Chenoweth MJ, et al. Among authors: ahluwalia js. Addiction. 2018 Mar;113(3):509-523. doi: 10.1111/add.14032. Epub 2017 Nov 2. Addiction. 2018. PMID: 28921760 Free PMC article.
394 results