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Two-pore channels (TPCs) acts as a hub for excitation-contraction coupling, metabolism and cardiac hypertrophy signalling.
de Zélicourt A, Fayssoil A, Mansart A, Zarrouki F, Karoui A, Piquereau J, Lefebvre F, Gerbaud P, Mika D, Dakouane-Giudicelli M, Lanchec E, Feng M, Leblais V, Bobe R, Launay JM, Galione A, Gomez AM, de la Porte S, Cancela JM. de Zélicourt A, et al. Among authors: karoui a. Cell Calcium. 2024 Jan;117:102839. doi: 10.1016/j.ceca.2023.102839. Epub 2023 Dec 16. Cell Calcium. 2024. PMID: 38134531
Sex-specific benefits of a combined supplementation of B vitamins, nicotinamide riboside, folate and cobalamin, in a murine model of heart failure.
Boitard SE, Delouche M, Karoui A, Gressette M, Momken I, Bouchard B, Mercier-Nomé F, Imbard A, Lemaire C, Garnier A, Ruiz M, Mericskay M, Piquereau J. Boitard SE, et al. Among authors: karoui a. Biol Sex Differ. 2025 Oct 21;16(1):82. doi: 10.1186/s13293-025-00764-x. Biol Sex Differ. 2025. PMID: 41121420 Free PMC article.
CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.
de Zélicourt A, Fayssoil A, Dakouane-Giudicelli M, De Jesus I, Karoui A, Zarrouki F, Lefebvre F, Mansart A, Launay JM, Piquereau J, Tarragó MG, Bonay M, Forand A, Moog S, Piétri-Rouxel F, Brisebard E, Chini CCS, Kashyap S, Fogarty MJ, Sieck GC, Mericskay M, Chini EN, Gomez AM, Cancela JM, de la Porte S. de Zélicourt A, et al. Among authors: karoui a. EMBO Mol Med. 2022 May 9;14(5):e12860. doi: 10.15252/emmm.202012860. Epub 2022 Mar 17. EMBO Mol Med. 2022. PMID: 35298089 Free PMC article.
CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury.
Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut PA, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry JP, Renet S, Mulder P, Wan D, Tesson L, Heslan JM, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego JL, do Rego JC, Afonso C, Hammock B, Madec AM, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. Leuillier M, et al. Among authors: karoui a. J Adv Res. 2023 Jan;43:163-174. doi: 10.1016/j.jare.2022.03.004. Epub 2022 Mar 12. J Adv Res. 2023. PMID: 36585106 Free PMC article.
Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only.
Grimbert L, Sanz MN, Gressette M, Rucker-Martin C, Novotova M, Solgadi A, Karoui A, Gomez S, Bedouet K, Jacquet E, Lemaire C, Veksler V, Mericskay M, Ventura-Clapier R, Piquereau J, Garnier A. Grimbert L, et al. Among authors: karoui a. Biol Sex Differ. 2021 Sep 17;12(1):52. doi: 10.1186/s13293-021-00394-z. Biol Sex Differ. 2021. PMID: 34535195 Free PMC article.
Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction.
Karoui A, Crochemore C, Harouki N, Corbière C, Preterre D, Vendeville C, Richard V, Fardel O, Lecureur V, Vaugeois JM, Sichel F, Mulder P, Monteil C. Karoui A, et al. Int J Environ Res Public Health. 2020 Jul 30;17(15):5526. doi: 10.3390/ijerph17155526. Int J Environ Res Public Health. 2020. PMID: 32751709 Free PMC article.
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