Ahn HS - Search Results

1

Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents.

Chackalamannil S, Xia Y, Greenlee WJ, Clasby M, Doller D, Tsai H, Asberom T, Czarniecki M, Ahn HS, Boykow G, Foster C, Agans-Fantuzzi J, Bryant M, Lau J, Chintala M. Chackalamannil S, et al. Among authors: ahn hs. J Med Chem. 2005 Sep 22;48(19):5884-7. doi: 10.1021/jm0502236. J Med Chem. 2005. PMID: 16161991

2

Development of proteinase-activated receptor 1 antagonists as therapeutic agents for thrombosis, restenosis and inflammatory diseases.

Ahn HS, Chackalamannil S, Boykow G, Graziano MP, Foster C. Ahn HS, et al. Curr Pharm Des. 2003;9(28):2349-65. doi: 10.2174/1381612033453884. Curr Pharm Des. 2003. PMID: 14529396 Review.

3

Potent non-peptide thrombin receptor antagonists.

Chackalamannil S, Ahn HS, Xia Y, Doller D, Foster C. Chackalamannil S, et al. Among authors: ahn hs. Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):37-45. doi: 10.2174/1568016033356706. Curr Med Chem Cardiovasc Hematol Agents. 2003. PMID: 15317289 Review.

4

Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists.

Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Foster C, Bryant M, Lau J. Clasby MC, et al. Among authors: ahn hs. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1544-8. doi: 10.1016/j.bmcl.2005.12.042. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16380251

5

Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring.

Xia Y, Chackalamannil S, Chan TM, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Tsai H, Wang Y, Ahn HS, Boykow GC, McPhail AT. Xia Y, et al. Among authors: ahn hs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4969-72. doi: 10.1016/j.bmcl.2006.06.042. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824760

6

Metabolism-based identification of a potent thrombin receptor antagonist.

Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee W, Kao G, Lin Y, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Foster C, Smith-Torhan A, Alton K, Bryant M, Hsieh Y, Lau J, Palamanda J. Clasby MC, et al. Among authors: ahn hs. J Med Chem. 2007 Jan 11;50(1):129-38. doi: 10.1021/jm061043e. J Med Chem. 2007. PMID: 17201416

7

Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.

Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tagat JR, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Hsieh Y, McPhail AT. Clasby MC, et al. Among authors: ahn hs. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3647-51. doi: 10.1016/j.bmcl.2007.04.061. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490877

8

Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring.

Xia Y, Chackalamannil S, Clasby M, Doller D, Eagen K, Greenlee WJ, Tsai H, Agans-Fantuzzi J, Ahn HS, Boykow GC, Hsieh Y, Lunn CA, Chintala M. Xia Y, et al. Among authors: ahn hs. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4509-13. doi: 10.1016/j.bmcl.2007.06.002. Epub 2007 Jun 15. Bioorg Med Chem Lett. 2007. PMID: 17574850

9

Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.

Chelliah MV, Chackalamannil S, Xia Y, Eagen K, Clasby MC, Gao X, Greenlee W, Ahn HS, Agans-Fantuzzi J, Boykow G, Hsieh Y, Bryant M, Palamanda J, Chan TM, Hesk D, Chintala M. Chelliah MV, et al. Among authors: ahn hs. J Med Chem. 2007 Oct 18;50(21):5147-60. doi: 10.1021/jm070704k. Epub 2007 Sep 14. J Med Chem. 2007. PMID: 17854166

10

Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.

Chackalamannil S, Wang Y, Greenlee WJ, Hu Z, Xia Y, Ahn HS, Boykow G, Hsieh Y, Palamanda J, Agans-Fantuzzi J, Kurowski S, Graziano M, Chintala M. Chackalamannil S, et al. Among authors: ahn hs. J Med Chem. 2008 Jun 12;51(11):3061-4. doi: 10.1021/jm800180e. Epub 2008 May 1. J Med Chem. 2008. PMID: 18447380

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