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Page 1
Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.
Vogeley C, Sondermann NC, Woeste S, Momin AA, Gilardino V, Hartung F, Heinen M, Maaß SK, Mescher M, Pollet M, Rolfes KM, Vogel CFA, Rossi A, Lang D, Arold ST, Nakamura M, Haarmann-Stemmann T. Vogeley C, et al. Environ Int. 2022 Jan;158:106989. doi: 10.1016/j.envint.2021.106989. Epub 2021 Nov 20. Environ Int. 2022. PMID: 34991250 Free PMC article.
However, toxicological risk assessment of AHR-modulating compounds as well as drug development is complicated by the fact that different ligands elicit remarkably different AHR responses. ...Moreover, both AHR agonists stimulated protein kinase C activity and …
However, toxicological risk assessment of AHR-modulating compounds as well as drug development is complicated by the fact that differ …
Anti-Inflammation Activity of Flavones and Their Structure-Activity Relationship.
Wang X, Cao Y, Chen S, Lin J, Bian J, Huang D. Wang X, et al. J Agric Food Chem. 2021 Jul 7;69(26):7285-7302. doi: 10.1021/acs.jafc.1c02015. Epub 2021 Jun 23. J Agric Food Chem. 2021. PMID: 34160206
Hydroxyl groups (-OH) are indispensable for the anti-inflammatory function of flavones, and -OH at the C-5 and C-4' positions enhance while -OH at the C-6, C-7, C-8, and C-3' positions attenuate their activity. Moreover, the C2-C3 single bond, -OH at the C-3 and B-r …
Hydroxyl groups (-OH) are indispensable for the anti-inflammatory function of flavones, and -OH at the C-5 and C-4' positions enhance while …
Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation.
Wang M, Hu HH, Chen YY, Chen L, Wu XQ, Zhao YY. Wang M, et al. Phytomedicine. 2020 Dec;79:153323. doi: 10.1016/j.phymed.2020.153323. Epub 2020 Sep 1. Phytomedicine. 2020. PMID: 32920287
Mechanistically, poricoic acid ZM (PZM) and poricoic acid ZP (PZP) attenuate renal fibrosis through the modulation of redox signalling including the inhibition of proinflammatory nuclear factor kappa B (NF-kappaB) signalling and its target genes as well as the activation o …
Mechanistically, poricoic acid ZM (PZM) and poricoic acid ZP (PZP) attenuate renal fibrosis through the modulation of redox signalling inclu …
Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella).
Liu S, Feng L, Jiang WD, Liu Y, Jiang J, Wu P, Zeng YY, Xu SD, Kuang SY, Tang L, Tang WN, Zhang YA, Zhou XQ. Liu S, et al. Fish Shellfish Immunol. 2016 Aug;55:88-105. doi: 10.1016/j.fsi.2016.05.006. Epub 2016 May 7. Fish Shellfish Immunol. 2016. PMID: 27164217

In addition, in low-protein and high-lipid diets, optimal exogenous lipase supplementation significantly increased acid phosphatase (ACP) activities and complement component 3 (C3) contents (P < 0.05), up-regulated the relative mRNA levels of antimicrobial peptides (liv

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In addition, in low-protein and high-lipid diets, optimal exogenous lipase supplementation significantly increased acid phosphatase (ACP) ac …
Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella).
Zhao HF, Jiang WD, Liu Y, Jiang J, Wu P, Kuang SY, Tang L, Tang WN, Zhang YA, Zhou XQ, Feng L. Zhao HF, et al. Fish Shellfish Immunol. 2016 May;52:139-50. doi: 10.1016/j.fsi.2016.03.029. Epub 2016 Mar 15. Fish Shellfish Immunol. 2016. PMID: 26988287

The results showed that optimal dietary choline supplementation significantly improved lysozyme and acid phosphatase activities, complement component 3 (C3) content, and the liver expressed antimicrobial peptide 2 and Hepcidin mRNA levels in the gills of fish (P < 0.05)

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The results showed that optimal dietary choline supplementation significantly improved lysozyme and acid phosphatase activities, complement …
Modulation of immune response, physical barrier and related signaling factors in the gills of juvenile grass carp (Ctenopharyngodon idella) fed supplemented diet with phospholipids.
Feng L, Chen YP, Jiang WD, Liu Y, Jiang J, Wu P, Zhao J, Kuang SY, Tang L, Tang WN, Zhang YA, Zhou XQ. Feng L, et al. Fish Shellfish Immunol. 2016 Jan;48:79-93. doi: 10.1016/j.fsi.2015.11.020. Epub 2015 Nov 14. Fish Shellfish Immunol. 2016. PMID: 26584756

Compared with the control group, optimal PL supplementation increased (P < 0.05): (1) the lysozyme activity, acid phosphatase activity, complement component 3 (C3) content, liver expressed antimicrobial peptide 1 (LEAP-1) and LEAP-2 mRNA expression; (2) the relative mRN

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Compared with the control group, optimal PL supplementation increased (P < 0.05): (1) the lysozyme activity, acid phosphatase activity, c

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Prenatal TCDD in mice increases adult autoimmunity.
Holladay SD, Mustafa A, Gogal RM Jr. Holladay SD, et al. Reprod Toxicol. 2011 Apr;31(3):312-8. doi: 10.1016/j.reprotox.2010.08.001. Epub 2010 Aug 20. Reprod Toxicol. 2011. PMID: 20728533 Free PMC article.
The C57BL/6 mouse has a high-affinity aryl hydrocarbon receptor (AhR) and is sensitive to TCDD. The SNF(1) mouse has a low-affinity AhR but spontaneously develops autoimmune nephritis. ...Male SNF(1) mice had increased anti-IgG and anti-C3 deposition in kidne …
The C57BL/6 mouse has a high-affinity aryl hydrocarbon receptor (AhR) and is sensitive to TCDD. The SNF(1) mouse has a low-affinity …
An enhanced postnatal autoimmune profile in 24 week-old C57BL/6 mice developmentally exposed to TCDD.
Mustafa A, Holladay SD, Goff M, Witonsky SG, Kerr R, Reilly CM, Sponenberg DP, Gogal RM Jr. Mustafa A, et al. Toxicol Appl Pharmacol. 2008 Oct 1;232(1):51-9. doi: 10.1016/j.taap.2008.04.015. Epub 2008 Apr 30. Toxicol Appl Pharmacol. 2008. PMID: 18534654 Free PMC article.
Developmental exposure of mice to the environmental contaminant and AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes persistent postnatal suppression of T cell-mediated immune responses. ...Immunofluorescent staining of IgG and C3 deposition in kidney …
Developmental exposure of mice to the environmental contaminant and AhR agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), causes p …
Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.
Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW. Taube C, et al. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8084-9. doi: 10.1073/pnas.0602357103. Epub 2006 May 15. Proc Natl Acad Sci U S A. 2006. PMID: 16702544 Free PMC article.
The development of AHR and airway inflammation in sensitized fB-/- mice could be restored after intranasal administration of purified factor B before the airway challenge. In addition, administration of a neutralizing anti-factor B mAb to sensitized mice befo …
The development of AHR and airway inflammation in sensitized fB-/- mice could be restored after intranasal administration of purified …