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828 results
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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. McDade E, et al. Among authors: aisen p. Nat Rev Neurol. 2021 Nov;17(11):703-714. doi: 10.1038/s41582-021-00545-1. Epub 2021 Sep 21. Nat Rev Neurol. 2021. PMID: 34548654 Review.
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y. Nishitomi K, et al. J Neurochem. 2006 Dec;99(6):1555-63. doi: 10.1111/j.1471-4159.2006.04178.x. Epub 2006 Nov 2. J Neurochem. 2006. PMID: 17083447 Free article.
Alzhemed: a potential treatment for Alzheimer's disease.
Aisen PS, Gauthier S, Vellas B, Briand R, Saumier D, Laurin J, Garceau D. Aisen PS, et al. Curr Alzheimer Res. 2007 Sep;4(4):473-8. doi: 10.2174/156720507781788882. Curr Alzheimer Res. 2007. PMID: 17908052 Review.
828 results