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The effect of enzyme induction on the metabolism of disopyramide in man.
Aitio ML, Mansury L, Tala E, Haataja M, Aitio A. Aitio ML, et al. Among authors: aitio a. Br J Clin Pharmacol. 1981 Mar;11(3):279-85. doi: 10.1111/j.1365-2125.1981.tb00535.x. Br J Clin Pharmacol. 1981. PMID: 7213529 Free PMC article.
Both in patients and volunteers a significant increase occurred in the urinary mono-N-dealkyldisopyramide/disopyramide ratio during the first week of disopyramide therapy. ...
Both in patients and volunteers a significant increase occurred in the urinary mono-N-dealkyldisopyramide/disopyramide ratio during t …
Induction of disopyramide N-dealkylation by phenobarbital and disopyramide in rat liver.
Aitio ML, Aitio A. Aitio ML, et al. Among authors: aitio a. Arch Int Pharmacodyn Ther. 1979 May;239(1):16-23. Arch Int Pharmacodyn Ther. 1979. PMID: 485713
Disopyramide also increased ethoxycoumarin deethylation 1.6 fold, and had a slight increasing effect on the activity of epoxide hydratase, but did not affect the activities of glutathione S-transferase or UDPglucuronosyltransferase....
Disopyramide also increased ethoxycoumarin deethylation 1.6 fold, and had a slight increasing effect on the activity of epoxide hydra …
Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.
Elovaara E, Vainio H, Aitio A. Elovaara E, et al. Among authors: aitio a. Arch Toxicol. 1990;64(5):365-9. doi: 10.1007/BF01973457. Arch Toxicol. 1990. PMID: 2403287
In these rats, only a marginal decrease was observed in the pulmonary cytochrome P450 oxidative metabolism. Following a single 24-h inhalation exposure to 500 cm3/m3 styrene, the decreases in GSH were 66% in lung but only 16% in liver. ...Inducer pretreatment seemed …
In these rats, only a marginal decrease was observed in the pulmonary cytochrome P450 oxidative metabolism. Following a single …
Effect of phthalate esters on drug metabolizing enzyme activities in rat liver.
Aitio A, Parkki M. Aitio A, et al. Arch Int Pharmacodyn Ther. 1978 Oct;235(2):187-95. Arch Int Pharmacodyn Ther. 1978. PMID: 736698
No statistically significant increase could be detected in the catalytic activities dependent on cytochrome P-450 (Benzo(a)pyrene hydroxylation, ethoxycoumarin deethylation). ...
No statistically significant increase could be detected in the catalytic activities dependent on cytochrome P-450 (Benzo(a)pyrene hyd …
Effects of inhalation and cutaneous exposure to styrene on drug metabolizing enzymes in the rat.
Sandell J, Parkki MG, Marniemi J, Aitio A. Sandell J, et al. Among authors: aitio a. Res Commun Chem Pathol Pharmacol. 1978 Jan;19(1):109-18. Res Commun Chem Pathol Pharmacol. 1978. PMID: 625579
Enhancement of microsomal drug hydroxylation and glucuronidation in rat liver by phenobarbital and 3-methylcholanthrene in combination.
Vainio H, Aitio A. Vainio H, et al. Among authors: aitio a. Acta Pharmacol Toxicol (Copenh). 1974 Feb;34(2):130-40. doi: 10.1111/j.1600-0773.1974.tb01649.x. Acta Pharmacol Toxicol (Copenh). 1974. PMID: 4207158 No abstract available.
UDP glucuronosyltransferase and mixed function oxidase activity in microsomes prepared by differential centrifugation and calcium aggregation.
Aitio A, Vainio H. Aitio A, et al. Acta Pharmacol Toxicol (Copenh). 1976;39(5):555-61. doi: 10.1111/j.1600-0773.1976.tb03205.x. Acta Pharmacol Toxicol (Copenh). 1976. PMID: 824931
However, the ultracentrifugation method resulted in a slightly smaller yield of the hepatic microsomal protein and a correspondingly higher yield of cytochrome P-450/448 per mg protein as well as higher specific enzymatic activities of both the consecutive drug biot …
However, the ultracentrifugation method resulted in a slightly smaller yield of the hepatic microsomal protein and a correspon …
m-Xylene inhalation destroys cytochrome P-450 in rat lung at low exposure.
Elovaara E, Zitting A, Nickels J, Aitio A. Elovaara E, et al. Among authors: aitio a. Arch Toxicol. 1987;61(1):21-6. doi: 10.1007/BF00324543. Arch Toxicol. 1987. PMID: 3439869
Morphologic studies of the lungs with scanning electron microscopy showed no apparent changes after exposure to 300 cm3/m3 or after a high oral dose (2 ml/kg/day, 3 days). Inhalation exposure to m-xylene for 5 weeks (7 h/day, 4 days/week) at a concentration of 300 p …
Morphologic studies of the lungs with scanning electron microscopy showed no apparent changes after exposure to 300 cm3/m3 or after a
Effect of metal salts on UDPglucuronosyltransferase activity of various aglycones in rat liver microsomes in vitro.
Aitio A, Ahotupa M, Parkki MG. Aitio A, et al. Eur J Drug Metab Pharmacokinet. 1980;5(1):35-40. doi: 10.1007/BF03189441. Eur J Drug Metab Pharmacokinet. 1980. PMID: 6771140
Effects of tetraethyl lead on the activities of drug metabolizing enzymes in different tissues of the rat.
Ahotupa M, Hartiala K, Aitio A. Ahotupa M, et al. Among authors: aitio a. Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):359-63. doi: 10.1111/j.1600-0773.1979.tb02345.x. Acta Pharmacol Toxicol (Copenh). 1979. PMID: 474147
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