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Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats.
Akagi JI, Cho YM, Mizuta Y, Toyoda T, Ogawa K. Akagi JI, et al. Food Chem Toxicol. 2018 Dec;122:80-86. doi: 10.1016/j.fct.2018.09.060. Epub 2018 Sep 25. Food Chem Toxicol. 2018. PMID: 30266315
A 13-week subchronic toxicity study of sodium iron chlorophyllin in F344 rats.
Toyoda T, Cho YM, Mizuta Y, Akagi J, Nishikawa A, Ogawa K. Toyoda T, et al. Among authors: akagi j. J Toxicol Sci. 2014 Feb;39(1):109-19. doi: 10.2131/jts.39.109. J Toxicol Sci. 2014. PMID: 24418715
A 13-week subchronic toxicity study of ferric citrate in F344 rats.
Toyoda T, Cho YM, Mizuta Y, Akagi J, Ogawa K. Toyoda T, et al. Among authors: akagi j. Food Chem Toxicol. 2014 Dec;74:68-75. doi: 10.1016/j.fct.2014.09.005. Epub 2014 Sep 26. Food Chem Toxicol. 2014. PMID: 25257695
Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.
Akagi J, Toyoda T, Cho YM, Mizuta Y, Nohmi T, Nishikawa A, Ogawa K. Akagi J, et al. Cancer Sci. 2015 May;106(5):529-41. doi: 10.1111/cas.12634. Epub 2015 Apr 10. Cancer Sci. 2015. PMID: 25683344 Free PMC article.
Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX.
Toyoda T, Cho YM, Akagi J, Mizuta Y, Hirata T, Nishikawa A, Ogawa K. Toyoda T, et al. Among authors: akagi j. Toxicol Sci. 2015 Dec;148(2):400-8. doi: 10.1093/toxsci/kfv192. Epub 2015 Sep 3. Toxicol Sci. 2015. PMID: 26338220
Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat.
Onami S, Cho YM, Toyoda T, Akagi J, Fujiwara S, Ochiai R, Tsujino K, Nishikawa A, Ogawa K. Onami S, et al. Among authors: akagi j. Regul Toxicol Pharmacol. 2015 Dec;73(3):726-31. doi: 10.1016/j.yrtph.2015.10.020. Epub 2015 Oct 28. Regul Toxicol Pharmacol. 2015. PMID: 26520183
Toxic effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity.
Suzuki I, Cho YM, Hirata T, Toyoda T, Akagi JI, Nakamura Y, Sasaki A, Nakamura T, Okamoto S, Shirota K, Suetome N, Nishikawa A, Ogawa K. Suzuki I, et al. Among authors: akagi ji. J Appl Toxicol. 2017 Apr;37(4):485-494. doi: 10.1002/jat.3384. Epub 2016 Sep 15. J Appl Toxicol. 2017. PMID: 27633481
Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination.
Hirata T, Cho YM, Toyoda T, Akagi JI, Suzuki I, Nishikawa A, Ogawa K. Hirata T, et al. Among authors: akagi ji. J Appl Toxicol. 2017 Jun;37(6):683-691. doi: 10.1002/jat.3416. Epub 2016 Nov 28. J Appl Toxicol. 2017. PMID: 27896817
Altered susceptibility of an obese rat model to 13-week subchronic toxicity induced by 3-monochloropropane-1,2-diol.
Toyoda T, Cho YM, Akagi JI, Mizuta Y, Matsushita K, Nishikawa A, Imaida K, Ogawa K. Toyoda T, et al. Among authors: akagi ji. J Toxicol Sci. 2017;42(1):1-11. doi: 10.2131/jts.42.1. J Toxicol Sci. 2017. PMID: 28070102
4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells.
Hirata T, Cho YM, Suzuki I, Toyoda T, Akagi JI, Nakamura Y, Numazawa S, Ogawa K. Hirata T, et al. Among authors: akagi ji. Food Chem Toxicol. 2018 Jan;111:295-301. doi: 10.1016/j.fct.2017.11.022. Epub 2017 Nov 16. Food Chem Toxicol. 2018. PMID: 29155359
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